HIV-1 Vpr Induces Widespread Transcriptomic Changes in CD4 + T Cells Early Postinfection

The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

(2021) Liane Dupont et al.   Cell Host & Microbe

Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal

(2020) Pengfei Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Network-Based Analysis of OMICs Data to Understand the HIV–Host Interaction

(2020) Sergey Ivanov et al.   Frontiers in Microbiology

Evolution of a concept: From accessory protein to key virulence factor, the case of HIV-1 Vpr

(2020) Clémentine Wallet et al.   BIOCHEMICAL PHARMACOLOGY

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

(2020) Hataf Khan et al.   eLife

Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection

(2019) Edward J.D. Greenwood et al.   Cell Reports

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

(2019) Simon Langer et al.   eLife

Interferon-Stimulated Genes: What Do They All Do?

(2019) John W. Schoggins   Annual Review of Virology

Vpr and Its Cellular Interaction Partners: R We There Yet?

(2019) Helena Fabryova et al.   Cells

Highly Attenuated Infection With a Vpr-Deleted Molecular Clone of Human Immunodeficiency Virus-1

(2018) Ayub Ali et al.   JOURNAL OF INFECTIOUS DISEASES

Vpr Targets TET2 for Degradation by CRL4 VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication

(2018) Lei Lv et al.   MOLECULAR CELL

HIV-2/SIV viral protein X counteracts HUSH repressor complex

(2018) Ghina Chougui et al.   Nature Microbiology

Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex

(2018) Leonid Yurkovetskiy et al.   Nature Microbiology

Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling

(2018) Adam J. Fletcher et al.   Cell Host & Microbe

HIV-1 Vpr Reprograms CLR4DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection

(2018) Junpeng Yan et al.   mBio

Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells

(2017) Caitlin M. Miller et al.   JOURNAL OF VIROLOGY

The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction

(2016) Ying Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction

(2016) Ying Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4 + T Cells

(2016) Jolien Vermeire et al.   Cell Reports

HIV-1 Vpr reactivates latent HIV-1 provirus by inducing depletion of class I HDACs on chromatin

(2016) Bizhan Romani et al.   Scientific Reports

PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1

(2015) Sunnie M. Yoh et al.   CELL

HIV-1 Vpr Protein Induces Proteasomal Degradation of Chromatin-associated Class I HDACs to Overcome Latent Infection of Macrophages

(2015) Bizhan Romani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sensing of HIV-1 Infection in Tzm-bl Cells with Reconstituted Expression of STING

(2015) Maud Trotard et al.   JOURNAL OF VIROLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Gene activity in primary T cells infected with HIV89.6: intron retention and induction of genomic repeats

(2015) Scott Sherrill-Mix et al.   Retrovirology

UpSet: Visualization of Intersecting Sets

(2014) Alexander Lex et al.   IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS

HIV-1 Vpr Induces Interferon-Stimulated Genes in Human Monocyte-Derived Macrophages

(2014) Muhammad Atif Zahoor et al.   PLoS One

HIV-1 Infection Causes a Down-Regulation of Genes Involved in Ribosome Biogenesis

(2014) Claudia L. Kleinman et al.   PLoS One

HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1

(2014) Ruikang Liu et al.   Retrovirology

HIV-1 Vpr—a still “enigmatic multitasker”

(2014) Carolin A. Guenzel et al.   Frontiers in Microbiology

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

HIV-1 Vpr Induces the Degradation of ZIP and sZIP, Adaptors of the NuRD Chromatin Remodeling Complex, by Hijacking DCAF1/VprBP

(2013) Claire Maudet et al.   PLoS One

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

24 Hours in the Life of HIV-1 in a T Cell Line

(2013) Pejman Mohammadi et al.   PLoS Pathogens

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

Inhibition of NF-κB activity by HIV-1 Vpr is dependent on Vpr binding protein

(2012) Michael Kogan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Exon Level Transcriptomic Profiling of HIV-1-Infected CD4+ T Cells Reveals Virus-Induced Genes and Host Environment Favorable for Viral Replication

(2012) Michaël Imbeault et al.   PLoS Pathogens

Analysis of HIV-1 Expression Level and Sense of Transcription by High-Throughput Sequencing of the Infected Cell

(2011) G. Lefebvre et al.   JOURNAL OF VIROLOGY

Generation of Transmitted/Founder HIV-1 Infectious Molecular Clones and Characterization of Their Replication Capacity in CD4 T Lymphocytes and Monocyte-Derived Macrophages

(2011) C. Ochsenbauer et al.   JOURNAL OF VIROLOGY

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

Next-Generation Sequencing Reveals HIV-1-Mediated Suppression of T Cell Activation and RNA Processing and Regulation of Noncoding RNA Expression in a CD4+ T Cell Line

(2011) S. T. Chang et al.   mBio

Innate Sensing of HIV-Infected Cells

(2011) Alice Lepelley et al.   PLoS Pathogens

Characterization of the Alpha Interferon-Induced Postentry Block to HIV-1 Infection in Primary Human Macrophages and T Cells

(2010) C. Goujon et al.   JOURNAL OF VIROLOGY

Optimizing the noise versus bias trade-off for Illumina whole genome expression BeadChips

(2010) Wei Shi et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide mRNA Expression Correlates of Viral Control in CD4+ T-Cells from HIV-1-Infected Individuals

(2010) Margalida Rotger et al.   PLoS Pathogens

Viral Genetic Determinants of Nonprogressive HIV Type 1 Subtype C Infection in Antiretroviral Drug-Naive Children

(2009) D.B. Tzitzivacos et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Testing significance relative to a fold-change threshold is a TREAT

(2009) D. J. McCarthy et al.   BIOINFORMATICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Human Immunodeficiency Virus Type 1 Mediates Global Disruption of Innate Antiviral Signaling and Immune Defenses within Infected Cells

(2009) B. P. Doehle et al.   JOURNAL OF VIROLOGY

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

(2008) B. F. Keele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells

(2008) J. Mercer et al.   SCIENCE

HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation

(2007) Atsushi Okumura et al.   VIROLOGY