Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

Active control of arousal by a locus coeruleus GABAergic circuit

(2019) Vincent Breton-Provencher et al.   NATURE NEUROSCIENCE

Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain

(2019) Clifford M. Cassidy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Magnetic resonance imaging of noradrenergic neurons

(2019) Takashi Watanabe et al.   Brain Structure & Function

18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal

(2018) Christopher M. Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study

(2018) Rana A Eser et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Locus Coeruleus Activity Strengthens Prioritized Memories Under Arousal

(2018) David V. Clewett et al.   JOURNAL OF NEUROSCIENCE

In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study

(2018) Karoline Knudsen et al.   LANCET NEUROLOGY

Curvilinear locus coeruleus functional connectivity trajectories over the adult lifespan: a 7T MRI study

(2018) Heidi I.L. Jacobs et al.   NEUROBIOLOGY OF AGING

High-resolution in vivo imaging of human locus coeruleus by magnetization transfer MRI at 3T and 7T

(2018) Nikos Priovoulos et al.   NEUROIMAGE

Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease

(2018) David Weinshenker   TRENDS IN NEUROSCIENCES

Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE)

(2018) Frank Jessen et al.   Alzheimers Research & Therapy

Commentary: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

(2018) Matthew J. Betts et al.   Frontiers in Neuroscience

On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease

(2018) Nicolas Giguère et al.   Frontiers in Neurology

Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer’s Disease

(2018) Alexander J. Ehrenberg et al.   JOURNAL OF ALZHEIMERS DISEASE

The choice of embedding media affects image quality, tissue R2 * , and susceptibility behaviors in post-mortem brain MR microscopy at 7.0T

(2018) Petr Dusek et al.   MAGNETIC RESONANCE IN MEDICINE

In vivo visualization of age-related differences in the locus coeruleus

(2018) Kathy Y. Liu et al.   NEUROBIOLOGY OF AGING

Effects of concentration and vendor specific composition of formalin on postmortem MRI of the human brain

(2017) Christoph Birkl et al.   MAGNETIC RESONANCE IN MEDICINE

Towards a mechanistic understanding of the human subcortex

(2017) Birte U. Forstmann et al.   NATURE REVIEWS NEUROSCIENCE

In vivo MRI assessment of the human locus coeruleus along its rostrocaudal extent in young and older adults

(2017) Matthew J. Betts et al.   NEUROIMAGE

Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting

(2017) Ryan R. Walsh et al.   NEUROLOGY

Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease

(2017) A. J. Ehrenberg et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Locus coeruleus at asymptomatic early and middle Braak stages of neurofibrillary tangle pathology

(2017) P. Andrés-Benito et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Magnetic resonance imaging of the human locus coeruleus: A systematic review

(2017) Kathy Y. Liu et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease

(2017) Sarah C. Kelly et al.   Acta Neuropathologica Communications

Altered miRNA expression network in locus coeruleus of depressed suicide subjects

(2017) Bhaskar Roy et al.   Scientific Reports

In vivoimaging of neuromelanin in Parkinson’s disease using18F-AV-1451 PET

(2016) Allan K. Hansen et al.   BRAIN

Elemental mapping of Neuromelanin organelles of human Substantia Nigra: correlative ultrastructural and chemical analysis by analytical transmission electron microscopy and nano-secondary ion mass spectrometry

(2016) Antje Biesemeier et al.   JOURNAL OF NEUROCHEMISTRY

In Vivo MRI Mapping of Brain Iron Deposition across the Adult Lifespan

(2016) J. Acosta-Cabronero et al.   JOURNAL OF NEUROSCIENCE

The noradrenergic locus coeruleus as a chronic pain generator

(2016) Bradley K. Taylor et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Contrast mechanisms associated with neuromelanin-MRI

(2016) Paula Trujillo et al.   MAGNETIC RESONANCE IN MEDICINE

Reproducibility of locus coeruleus and substantia nigra imaging with neuromelanin sensitive MRI

(2016) Jason Langley et al.   MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

Locus coeruleus and dopaminergic consolidation of everyday memory

(2016) Tomonori Takeuchi et al.   NATURE

Neuromelanin marks the spot: identifying a locus coeruleus biomarker of cognitive reserve in healthy aging

(2016) David V. Clewett et al.   NEUROBIOLOGY OF AGING

High-resolution characterisation of the aging brain using simultaneous quantitative susceptibility mapping (QSM) and R 2 * measurements at 7 T

(2016) Matthew J. Betts et al.   NEUROIMAGE

Noradrenergic Locus Coeruleus pathways in pain modulation

(2016) Meritxell Llorca-Torralba et al.   NEUROSCIENCE

Effects of formalin fixation and temperature on MR relaxation times in the human brain

(2016) Christoph Birkl et al.   NMR IN BIOMEDICINE

Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory

(2016) Kimberly A. Kempadoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging synaptic density in the living human brain

(2016) Sjoerd J. Finnema et al.   Science Translational Medicine

The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain

(2016) Mara Mather et al.   TRENDS IN COGNITIVE SCIENCES

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

(2015) Marta Marquié et al.   ANNALS OF NEUROLOGY

Deep clinical and neuropathological phenotyping of Pick disease

(2015) David J. Irwin et al.   ANNALS OF NEUROLOGY

Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory

(2015) Mara Mather et al.   BEHAVIORAL AND BRAIN SCIENCES

Improving Response Inhibition in Parkinson’s Disease with Atomoxetine

(2015) Zheng Ye et al.   BIOLOGICAL PSYCHIATRY

Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology

(2015) Katharina Stratmann et al.   BRAIN PATHOLOGY

Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from thelocus coeruleus

(2015) Kazumasa Wakamatsu et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia

(2015) Heidi I.L. Jacobs et al.   NEUROBIOLOGY OF AGING

A multicontrast approach for comprehensive imaging of substantia nigra

(2015) Jason Langley et al.   NEUROIMAGE

Histologic validation of locus coeruleus MRI contrast in post-mortem tissue

(2015) Noam I. Keren et al.   NEUROIMAGE

Early neurone loss in Alzheimer’s disease: cortical or subcortical?

(2015) Thomas Arendt et al.   Acta Neuropathologica Communications

The Brainstem Pathologies of Parkinson's Disease and Dementia with Lewy Bodies

(2014) Kay Seidel et al.   BRAIN PATHOLOGY

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Simultaneous imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach

(2014) Xiangchuan Chen et al.   MAGNETIC RESONANCE IMAGING

Norepinephrine deficiency in Parkinson's disease: The case for noradrenergic enhancement

(2014) Alberto J. Espay et al.   MOVEMENT DISORDERS

Cognitive impairment in multiple system atrophy: A position statement by the neuropsychology task force of the MDS multiple system atrophy (MODIMSA) study group

(2014) Iva Stankovic et al.   MOVEMENT DISORDERS

Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel

(2014) Thor D Stein et al.   Alzheimers Research & Therapy

The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease

(2013) Daniel García-Lorenzo et al.   BRAIN

Neuromelanin Magnetic Resonance Imaging in Parkinson's Disease and Multiple System Atrophy

(2013) Keita Matsuura et al.   EUROPEAN NEUROLOGY

Assessment of trace elements in human brain using inductively coupled plasma mass spectrometry

(2013) Nikolaus Krebs et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Temperature-induced changes of magnetic resonance relaxation times in the human brain: A postmortem study

(2013) Christoph Birkl et al.   MAGNETIC RESONANCE IN MEDICINE

Clinical presentation of chronic traumatic encephalopathy

(2013) R. A. Stern et al.   NEUROLOGY

Neural reserve, neuronal density in the locus ceruleus, and cognitive decline

(2013) R. S. Wilson et al.   NEUROLOGY

Association of Posttraumatic Stress Disorder With Reduced In Vivo Norepinephrine Transporter Availability in the Locus Coeruleus

(2013) Robert H. Pietrzak et al.   JAMA Psychiatry

Quantitative multi-parameter mapping of R1, PD*, MT, and R2* at 3T: a multi-center validation

(2013) Nikolaus Weiskopf et al.   Frontiers in Neuroscience

A Synopsis on the Role of Tyrosine Hydroxylase in Parkinson’s Disease

(2012) Shams Tabrez et al.   CNS & Neurological Disorders-Drug Targets

Where, when, and in what form does sporadic Alzheimerʼs disease begin?

(2012) Heiko Braak et al.   CURRENT OPINION IN NEUROLOGY

A noradrenergic theory of cognitive reserve: implications for Alzheimer's disease

(2012) Ian H. Robertson   NEUROBIOLOGY OF AGING

Neuromelanins of Human Brain Have Soluble and Insoluble Components with Dolichols Attached to the Melanic Structure

(2012) Mireille Engelen et al.   PLoS One

Differential degeneration of the locus coeruleus in dementia subtypes

(2011) H. Brunnström et al.   CLINICAL NEUROPATHOLOGY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The noradrenaline precursor L-DOPS reduces pathology in a mouse model of Alzheimer's disease

(2011) Sergey Kalinin et al.   NEUROBIOLOGY OF AGING

Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease

(2010) Pamela J. McMillan et al.   BRAIN RESEARCH

Altered expression of glutamate signaling, growth factor and glia genes in the locus coeruleus of patients with major depression

(2010) R Bernard et al.   MOLECULAR PSYCHIATRY

Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits

(2010) Daniel Jardanhazi-Kurutz et al.   NEUROCHEMISTRY INTERNATIONAL

Comparative anatomy of the locus coeruleus in humans and nonhuman primates

(2009) Yukti Sharma et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The locus coeruleus and noradrenergic modulation of cognition

(2009) Susan J. Sara   NATURE REVIEWS NEUROSCIENCE

In vivo mapping of the human locus coeruleus

(2009) Noam I. Keren et al.   NEUROIMAGE

The locus ceruleus norepinephrine system: Functional organization and potential clinical significance

(2009) E. E. Benarroch   NEUROLOGY

The Reward Circuit: Linking Primate Anatomy and Human Imaging

(2009) Suzanne N Haber et al.   NEUROPSYCHOPHARMACOLOGY

Loss of A5 noradrenergic neurons in multiple system atrophy

(2008) Eduardo E. Benarroch et al.   ACTA NEUROPATHOLOGICA

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease

(2008) Dennis W. Dickson et al.   ACTA NEUROPATHOLOGICA

Visualization of Neuromelanin in the Substantia Nigra and Locus Ceruleus at 1.5T Using a 3D-gradient Echo Sequence with Magnetization Transfer Contrast

(2008) Toshiki NAKANE et al.   Magnetic Resonance in Medical Sciences