First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes

Polyclonal epitope mapping reveals temporal dynamics and diversity of human antibody responses to H5N1 vaccination

(2021) Julianna Han et al.   Cell Reports

Pre-existing immunity to influenza virus hemagglutinin stalk might drive selection for antibody-escape mutant viruses in a human challenge model

(2020) Jae-Keun Park et al.   NATURE MEDICINE

Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses

(2020) Nicholas C. Wu et al.   SCIENCE

Influenza vaccine–induced human bone marrow plasma cells decline within a year after vaccination

(2020) Carl W. Davis et al.   SCIENCE

Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses

(2020) Jenna J. Guthmiller et al.   IMMUNITY

Human germinal centres engage memory and naive B cells after influenza vaccination

(2020) Jackson S. Turner et al.   NATURE

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

(2020) Raffael Nachbagauer et al.   NATURE MEDICINE

Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans

(2020) Haley L. Dugan et al.   Science Translational Medicine

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

(2019) Masaru Kanekiyo et al.   NATURE IMMUNOLOGY

Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals

(2019) Carole Henry et al.   Cell Host & Microbe

A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface

(2019) Sandhya Bangaru et al.   CELL

Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism

(2019) Akiko Watanabe et al.   CELL

Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope

(2019) Goran Bajic et al.   Cell Host & Microbe

Development of Influenza B Universal Vaccine Candidates Using the “Mosaic” Hemagglutinin Approach

(2019) Weina Sun et al.   JOURNAL OF VIROLOGY

Protect, modify, deprotect (PMD): A strategy for creating vaccines to elicit antibodies targeting a specific epitope

(2019) Payton A. Weidenbacher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin

(2019) Sarah F. Andrews et al.   IMMUNITY

Outflanking immunodominance to target subdominant broadly neutralizing epitopes

(2019) Davide Angeletti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mosaic hemagglutinin-based influenza virus vaccine candidate protects mice from challenge with divergent H3N2 strains

(2019) Felix Broecker et al.   npj Vaccines

Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies

(2018) Yao-Qing Chen et al.   CELL

Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires

(2018) Kevin R. McCarthy et al.   IMMUNITY

Identification of human vaccinees that possess antibodies targeting the egg-adapted hemagglutinin receptor binding site of an H1N1 influenza vaccine strain

(2018) Tyler A. Garretson et al.   VACCINE

Determinant of receptor-preference switch in influenza hemagglutinin

(2018) Fengyun Ni et al.   VIROLOGY

A Highly Potent and Broadly Neutralizing H1 Influenza-Specific Human Monoclonal Antibody

(2018) Aitor Nogales et al.   Scientific Reports

The influenza virus hemagglutinin head evolves faster than the stalk domain

(2018) Ericka Kirkpatrick et al.   Scientific Reports

Antigenic sites in influenza H1 hemagglutinin display species-specific immunodominance

(2018) Sean T. H. Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem

(2018) Hyon-Xhi Tan et al.   JOURNAL OF CLINICAL INVESTIGATION

Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination

(2018) Karlynn E. Neu et al.   JOURNAL OF CLINICAL INVESTIGATION

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Modeling and docking of antibody structures with Rosetta

(2017) Brian D Weitzner et al.   Nature Protocols

Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody

(2017) Donald D. Raymond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

(2017) Paul E. Leon et al.   Jove-Journal of Visualized Experiments

Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection

(2016) Carole J. Henry Dunand et al.   Cell Host & Microbe

Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain

(2016) Donald D Raymond et al.   NATURE MEDICINE

Multi-epitope Models Explain How Pre-existing Antibodies Affect the Generation of Broadly Protective Responses to Influenza

(2016) Veronika I. Zarnitsyna et al.   PLoS Pathogens

Origins of the 2009 H1N1 influenza pandemic in swine in Mexico

(2016) Ignacio Mena et al.   eLife

Viral Receptor-Binding Site Antibodies with Diverse Germline Origins

(2015) Aaron G. Schmidt et al.   CELL

Preexisting human antibodies neutralize recently emerged H7N9 influenza strains

(2015) Carole J. Henry Dunand et al.   JOURNAL OF CLINICAL INVESTIGATION

Focused antibody response to influenza linked to antigenic drift

(2015) Kuan-Ying A. Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

Masking of antigenic epitopes by antibodies shapes the humoral immune response to influenza

(2015) Veronika I. Zarnitsyna et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Immune history profoundly affects broadly protective B cell responses to influenza

(2015) Sarah F. Andrews et al.   Science Translational Medicine

Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site

(2015) Aaron G. Schmidt et al.   Cell Reports

Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season

(2014) S. L. Linderman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans

(2014) A. H. Ellebedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site

(2013) M. Hong et al.   JOURNAL OF VIROLOGY

Serverification of Molecular Modeling Applications: The Rosetta Online Server That Includes Everyone (ROSIE)

(2013) Sergey Lyskov et al.   PLoS One

Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

(2013) B. F. Koel et al.   SCIENCE

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Cross-neutralization of influenza A viruses mediated by a single antibody loop

(2012) Damian C. Ekiert et al.   NATURE

Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells

(2012) G.-M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

(2011) Jens Wrammert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin

(2011) J. R. R. Whittle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus

(2010) R. Xu et al.   SCIENCE

Protection of Mice against Lethal Challenge with 2009 H1N1 Influenza A Virus by 1918-Like and Classical Swine H1N1 Based Vaccines

(2010) Balaji Manicassamy et al.   PLoS Pathogens

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Appion: An integrated, database-driven pipeline to facilitate EM image processing

(2009) Gabriel C. Lander et al.   JOURNAL OF STRUCTURAL BIOLOGY

Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen

(2009) Kenneth Smith et al.   Nature Protocols

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

(2008) Jens Wrammert et al.   NATURE