A mosaic hemagglutinin-based influenza virus vaccine candidate protects mice from challenge with divergent H3N2 strains

Cross-reactive antibodies binding to H4 hemagglutinin protect against a lethal H4N6 influenza virus challenge in the mouse model

(2019) Fatima Amanat et al.   Emerging Microbes & Infections

Development of Influenza B Universal Vaccine Candidates Using the “Mosaic” Hemagglutinin Approach

(2019) Weina Sun et al.   JOURNAL OF VIROLOGY

The influenza B virus hemagglutinin head domain is less tolerant to transposon mutagenesis than that of the influenza A virus

(2018) Benjamin O. Fulton et al.   JOURNAL OF VIROLOGY

Structural insights into the design of novel anti-influenza therapies

(2018) Nicholas C. Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into the design of novel anti-influenza therapies

(2018) Nicholas C. Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cross-reactive mouse monoclonal antibodies raised against the hemagglutinin of A/Shanghai/1/2013 (H7N9) protect against novel H7 virus isolates in the mouse model

(2018) Daniel Stadlbauer et al.   Emerging Microbes & Infections

Mouse Models of Influenza Infection with Circulating Strains to Test Seasonal Vaccine Efficacy

(2018) Helen T. Groves et al.   Frontiers in Immunology

Influenza

(2018) Florian Krammer et al.   Nature Reviews Disease Primers

Immunodominance of Antigenic Site B in the Hemagglutinin of the Current H3N2 Influenza Virus in Humans and Mice

(2018) Felix Broecker et al.   JOURNAL OF VIROLOGY

Universal influenza virus vaccines that target the conserved hemagglutinin stalk and conserved sites in the head domain

(2018) Florian Krammer et al.   JOURNAL OF INFECTIOUS DISEASES

Influenza

(2018) Patrick Gavigan et al.   CURRENT OPINION IN PEDIATRICS

Chimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model

(2017) Megan E. Ermler et al.   JOURNAL OF VIROLOGY

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains

(2017) Seth J. Zost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effectiveness of MF59-adjuvanted seasonal influenza vaccine in the elderly: A systematic review and meta-analysis

(2017) Alexander Domnich et al.   VACCINE

Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model

(2017) Henning Jacobsen et al.   mBio

Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

(2017) Wenqian He et al.   Nature Communications

A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies

(2017) Raffael Nachbagauer et al.   npj Vaccines

Generation of a serum free CHO DG44 cell line stably producing a broadly protective anti-influenza virus monoclonal antibody

(2017) Veronika Chromikova et al.   PLoS One

Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins

(2016) Chi-Jene Chen et al.   JOURNAL OF VIROLOGY

Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact

(2016) Paul E. Leon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner

(2016) Caitlin E. Mullarkey et al.   mBio

Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets

(2015) Raffael Nachbagauer et al.   JOURNAL OF VIROLOGY

Assessment of Influenza Virus Hemagglutinin Stalk-Based Immunity in Ferrets

(2014) F. Krammer et al.   JOURNAL OF VIROLOGY

Characterization of a Broadly Neutralizing Monoclonal Antibody That Targets the Fusion Domain of Group 2 Influenza A Virus Hemagglutinin

(2014) G. S. Tan et al.   JOURNAL OF VIROLOGY

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

(2014) David J DiLillo et al.   NATURE MEDICINE

Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virus

(2014) Peter S. Lee et al.   Nature Communications

Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis

(2013) Andrea C Tricco et al.   BMC Medicine

Hemagglutinin Stalk-Based Universal Vaccine Constructs Protect against Group 2 Influenza A Viruses

(2013) I. Margine et al.   JOURNAL OF VIROLOGY

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

(2013) Rongbao Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age Distribution of Influenza Like Illness Cases during Post-Pandemic A(H3N2): Comparison with the Twelve Previous Seasons, in France

(2013) Clément Turbelin et al.   PLoS One

Correlates of protection to influenza virus, where do we go from here?

(2013) Rebecca Cox   Human Vaccines & Immunotherapeutics

Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes

(2012) R. Hai et al.   JOURNAL OF VIROLOGY

A Carboxy-Terminal Trimerization Domain Stabilizes Conformational Epitopes on the Stalk Domain of Soluble Recombinant Hemagglutinin Substrates

(2012) Florian Krammer et al.   PLoS One

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Differences in Patient Age Distribution between Influenza A Subtypes

(2009) Hossein Khiabanian et al.   PLoS One

The genomic and epidemiological dynamics of human influenza A virus

(2008) Andrew Rambaut et al.   NATURE

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

(2008) Jens Wrammert et al.   NATURE