A human apolipoprotein L with detergent-like activity kills intracellular pathogens

Antimicrobial host defence peptides: functions and clinical potential

(2020) Neeloffer Mookherjee et al.   NATURE REVIEWS DRUG DISCOVERY

Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions

(2020) Miriam Kutsch et al.   EMBO JOURNAL

Structural cells are key regulators of organ-specific immune responses

(2020) Thomas Krausgruber et al.   NATURE

Structure of the essential inner membrane lipopolysaccharide–PbgA complex

(2020) Thomas Clairfeuille et al.   NATURE

Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms

(2020) Michal P. Wandel et al.   NATURE IMMUNOLOGY

Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes

(2020) Antonio Rausell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

(2020) José Carlos Santos et al.   Nature Communications

Polymyxins and Their Potential Next Generation as Therapeutic Antibiotics

(2019) Martti Vaara   Frontiers in Microbiology

Human inborn errors of immunity to infection affecting cells other than leukocytes: from the immune system to the whole organism

(2019) Shen-Ying Zhang et al.   CURRENT OPINION IN IMMUNOLOGY

Identifying key membrane protein lipid interactions using mass spectrometry

(2018) Kallol Gupta et al.   Nature Protocols

Chemical Additives Enable Native Mass Spectrometry Measurement of Membrane Protein Oligomeric State within Intact Nanodiscs

(2018) James E. Keener et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

The role of interfacial lipids in stabilizing membrane protein oligomers

(2017) Kallol Gupta et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

APOLs with low pH dependence can kill all African trypanosomes

(2017) Frédéric Fontaine et al.   Nature Microbiology

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance

(2017) Jonathan M. Stokes et al.   Nature Microbiology

Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation

(2016) Thanh Ngoc Nguyen et al.   JOURNAL OF CELL BIOLOGY

Functional Interaction between Apolipophorins and Complement Regulate the Mosquito Immune Response to Systemic Infections

(2016) Layla Kamareddine et al.   Journal of Innate Immunity

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

A 3′ UTR-Derived Small RNA Provides the Regulatory Noncoding Arm of the Inner Membrane Stress Response

(2016) Yanjie Chao et al.   MOLECULAR CELL

Interferon-induced guanylate-binding proteins in inflammasome activation and host defense

(2016) Bae-Hoon Kim et al.   NATURE IMMUNOLOGY

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity

(2015) R. G. Gaudet et al.   SCIENCE

Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters

(2014) S. Helaine et al.   SCIENCE

CAPITO—a web server-based analysis and plotting tool for circular dichroism data

(2013) Christoph Wiedemann et al.   BIOINFORMATICS

Outer Membrane Permeabilization Is an Essential Step in the Killing of Gram-Negative Bacteria by the Lectin RegIIIβ

(2013) Tsuyoshi Miki et al.   PLoS One

Cellular Self-Defense: How Cell-Autonomous Immunity Protects Against Pathogens

(2013) F. Randow et al.   SCIENCE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Identification of Salmonella Pathogenicity Island-2 Type III Secretion System Effectors Involved in Intramacrophage Replication of S. enterica Serovar Typhimurium: Implications for Rational Vaccine Design

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Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals

(2012) A. R. Shenoy et al.   SCIENCE

Effect of Deletion of Genes Involved in Lipopolysaccharide Core and O-Antigen Synthesis on Virulence and Immunogenicity of Salmonella enterica Serovar Typhimurium

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Engineering Antibody Fitness and Function Using Membrane-Anchored Display of Correctly Folded Proteins

(2011) Amy J. Karlsson et al.   JOURNAL OF MOLECULAR BIOLOGY

A Family of IFN- -Inducible 65-kD GTPases Protects Against Bacterial Infection

(2011) B.-H. Kim et al.   SCIENCE

Involvement of apolipophorin III in antibacterial defense of Galleria mellonella larvae

(2010) Agnieszka Zdybicka-Barabas et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Dissemination of invasiveSalmonellavia bacterial-induced extrusion of mucosal epithelia

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Membrane potential is important for bacterial cell division

(2010) H. Strahl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions

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Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-α/β, IFN-γ, and IFN-λ in host defense

(2009) Shen-Ying Zhang et al.   IMMUNOLOGICAL REVIEWS

The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway

(2009) Y. T. Zheng et al.   JOURNAL OF IMMUNOLOGY

HELIQUEST: a web server to screen sequences with specific  -helical properties

(2008) R. Gautier et al.   BIOINFORMATICS

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY