标题
Discovery and implications of polygenicity of common diseases
作者
关键词
-
出版物
SCIENCE
Volume 373, Issue 6562, Pages 1468-1473
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2021-09-24
DOI
10.1126/science.abi8206
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Disentangling selection on genetically correlated polygenic traits via whole-genome genealogies
- (2021) Aaron J. Stern et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Genetically Predicted Blood Pressure and Risk of Atrial Fibrillation
- (2021) Matthew C. Hyman et al. HYPERTENSION
- The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation
- (2021) Samuel A. Lambert et al. NATURE GENETICS
- Widespread signatures of natural selection across human complex traits and functional genomic categories
- (2021) Jian Zeng et al. Nature Communications
- GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background
- (2021) Nasa Sinnott-Armstrong et al. eLife
- Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney
- (2021) James M. Eales et al. NATURE GENETICS
- Problems with Using Polygenic Scores to Select Embryos
- (2021) Patrick Turley et al. NEW ENGLAND JOURNAL OF MEDICINE
- From variant to function in human disease genetics
- (2021) Tuuli Lappalainen et al. SCIENCE
- Resource profile and user guide of the Polygenic Index Repository
- (2021) Joel Becker et al. Nature Human Behaviour
- Pathway paradigms revealed from the genetics of inflammatory bowel disease
- (2020) Daniel B. Graham et al. NATURE
- Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression
- (2020) Jamie E. Craig et al. NATURE GENETICS
- The mutational constraint spectrum quantified from variation in 141,456 humans
- (2020) Konrad J. Karczewski et al. NATURE
- Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model
- (2020) Dominic Holland et al. PLoS Genetics
- Using genetics for social science
- (2020) K. Paige Harden et al. Nature Human Behaviour
- Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
- (2020) Qian Zhang et al. Nature Communications
- Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions
- (2020) Akl C. Fahed et al. Nature Communications
- When a common biological role does not imply common disease outcomes: Disparate pathology linked to human mitochondrial aminoacyl-tRNA synthetases
- (2019) Ligia Elena González-Serrano et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
- (2019) Simon Haworth et al. Nature Communications
- Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
- (2019) Armin P. Schoech et al. Nature Communications
- Clinical use of current polygenic risk scores may exacerbate health disparities
- (2019) Alicia R. Martin et al. NATURE GENETICS
- Complex Trait Prediction from Genome Data: Contrasting EBV in Livestock to PRS in Humans
- (2019) Naomi R. Wray et al. GENETICS
- Polygenic prediction via Bayesian regression and continuous shrinkage priors
- (2019) Tian Ge et al. Nature Communications
- Extreme Polygenicity of Complex Traits Is Explained by Negative Selection
- (2019) Luke J. O'Connor et al. AMERICAN JOURNAL OF HUMAN GENETICS
- CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset
- (2019) Jong-Min Lee et al. CELL
- A method for genome-wide genealogy estimation for thousands of samples
- (2019) Leo Speidel et al. NATURE GENETICS
- Improved polygenic prediction by Bayesian multiple regression on summary statistics
- (2019) Luke R. Lloyd-Jones et al. Nature Communications
- Genetic correlates of social stratification in Great Britain
- (2019) Abdel Abdellaoui et al. Nature Human Behaviour
- The nature of nurture: Effects of parental genotypes
- (2018) Augustine Kong et al. SCIENCE
- Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
- (2018) Neil M Davies et al. BMJ-British Medical Journal
- Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
- (2018) Neil M Davies et al. BMJ-British Medical Journal
- Common genetic variants contribute to risk of rare severe neurodevelopmental disorders
- (2018) Mari E. K. Niemi et al. NATURE
- Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits
- (2018) Yan Zhang et al. NATURE GENETICS
- Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
- (2018) Amit V. Khera et al. NATURE GENETICS
- Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations
- (2018) Steven Gazal et al. NATURE GENETICS
- Leveraging Polygenic Functional Enrichment to Improve GWAS Power
- (2018) Gleb Kichaev et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes
- (2018) Nasim Mavaddat et al. AMERICAN JOURNAL OF HUMAN GENETICS
- An atlas of genetic associations in UK Biobank
- (2018) Oriol Canela-Xandri et al. NATURE GENETICS
- Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores
- (2017) Julie Lecarpentier et al. JOURNAL OF CLINICAL ONCOLOGY
- Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers
- (2017) Karoline B Kuchenbaecker et al. JNCI-Journal of the National Cancer Institute
- Reevaluation of SNP heritability in complex human traits
- (2017) Doug Speed et al. NATURE GENETICS
- Recent Advances in Mitochondrial Aminoacyl-tRNA Synthetases and Disease
- (2017) Marie Sissler et al. TRENDS IN MOLECULAR MEDICINE
- Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers
- (2017) Karoline B Kuchenbaecker et al. JNCI-Journal of the National Cancer Institute
- The genetic architecture of type 2 diabetes
- (2016) Christian Fuchsberger et al. NATURE
- The road to precision psychiatry: translating genetics into disease mechanisms
- (2016) Michael J Gandal et al. NATURE NEUROSCIENCE
- Dissecting the genetics of complex traits using summary association statistics
- (2016) Bogdan Pasaniuc et al. NATURE REVIEWS GENETICS
- Detection of human adaptation during the past 2000 years
- (2016) Yair Field et al. SCIENCE
- Partitioning heritability by functional annotation using genome-wide association summary statistics
- (2015) Hilary K Finucane et al. NATURE GENETICS
- FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
- (2015) Melina Claussnitzer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Comparative analysis of metazoan chromatin organization
- (2014) Joshua W. K. Ho et al. NATURE
- Obesity-associated variants within FTO form long-range functional connections with IRX3
- (2014) Scott Smemo et al. NATURE
- The mystery of missing heritability: Genetic interactions create phantom heritability
- (2012) O. Zuk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies
- (2010) A. Eyre-Walker PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sporadic cases are the norm for complex disease
- (2009) Jian Yang et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Linkage disequilibrium — understanding the evolutionary past and mapping the medical future
- (2008) Montgomery Slatkin NATURE REVIEWS GENETICS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started