Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

Genome-wide association analysis of 95,549 individuals identifies novel loci and genes influencing optic disc morphology

(2019) Xikun Han et al.   HUMAN MOLECULAR GENETICS

Genome-wide association analyses identify new loci influencing intraocular pressure

(2018) X Raymond Gao et al.   HUMAN MOLECULAR GENETICS

Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma

(2018) Anthony P. Khawaja et al.   NATURE GENETICS

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma

(2018) Stuart MacGregor et al.   NATURE GENETICS

Multi-trait analysis of genome-wide association summary statistics using MTAG

(2018) Patrick Turley et al.   NATURE GENETICS

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

(2018) Hélène Choquet et al.   Nature Communications

Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma

(2018) Rebecca King et al.   PLoS Genetics

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Myocilin Gene Gln368Ter Variant Penetrance and Association With Glaucoma in Population-Based and Registry-Based Studies

(2018) Xikun Han et al.   JAMA Ophthalmology

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population

(2018) Lulin Huang et al.   Science China-Life Sciences

Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores

(2017) Julie Lecarpentier et al.   JOURNAL OF CLINICAL ONCOLOGY

Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers

(2017) Karoline B Kuchenbaecker et al.   JNCI-Journal of the National Cancer Institute

Classification of common human diseases derived from shared genetic and environmental determinants

(2017) Kanix Wang et al.   NATURE GENETICS

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Glaucoma and intraocular pressure in EPIC-Norfolk Eye Study: cross sectional study

(2017) Michelle P Y Chan et al.   BMJ-British Medical Journal

Glaucoma and intraocular pressure in EPIC-Norfolk Eye Study: cross sectional study

(2017) Michelle P Y Chan et al.   BMJ-British Medical Journal

Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers

(2017) Karoline B Kuchenbaecker et al.   JNCI-Journal of the National Cancer Institute

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial

(2015) David F Garway-Heath et al.   LANCET

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma

(2014) Puya Gharahkhani et al.   NATURE GENETICS

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Nine Loci for Ocular Axial Length Identified through Genome-wide Association Studies, Including Shared Loci with Refractive Error

(2013) Ching-Yu Cheng et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

(2013) Virginie J M Verhoeven et al.   NATURE GENETICS

Power and Predictive Accuracy of Polygenic Risk Scores

(2013) Frank Dudbridge   PLoS Genetics

Cohort profile: The QSkin Sun and Health Study

(2012) C. M. Olsen et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

The NEIGHBOR Consortium Primary Open-Angle Glaucoma Genome-wide Association Study

(2012) Janey L. Wiggs et al.   JOURNAL OF GLAUCOMA

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

pROC: an open-source package for R and S+ to analyze and compare ROC curves

(2011) Xavier Robin et al.   BMC BIOINFORMATICS

Australian and New Zealand Registry of Advanced Glaucoma: methodology and recruitment

(2011) Emmanuelle Souzeau et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

The Heritability of Ocular Traits

(2010) Paul G. Sanfilippo et al.   SURVEY OF OPHTHALMOLOGY

THE VARIATION AND COVARIATION OF CUP AND DISC DIAMETERS

(2009) BO BENGTSSON   ACTA OPHTHALMOLOGICA

Primary Open-Angle Glaucoma

(2009) Young H. Kwon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myocilinallele-specific glaucoma phenotype database

(2007) Alex W. Hewitt et al.   HUMAN MUTATION