Disentangling selection on genetically correlated polygenic traits via whole-genome genealogies

A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits

(2020) Andy Dahl et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Variable prediction accuracy of polygenic scores within an ancestry group

(2020) Hakhamanesh Mostafavi et al.   eLife

Liability threshold modeling of case–control status and family history of disease increases association power

(2020) Margaux L. A. Hujoel et al.   NATURE GENETICS

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

(2019) Armin P. Schoech et al.   Nature Communications

Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

(2019) Mashaal Sohail et al.   eLife

Reduced signal for polygenic adaptation of height in UK Biobank

(2019) Jeremy J Berg et al.   eLife

Extreme Polygenicity of Complex Traits Is Explained by Negative Selection

(2019) Luke J. O'Connor et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A global overview of pleiotropy and genetic architecture in complex traits

(2019) Kyoko Watanabe et al.   NATURE GENETICS

A method for genome-wide genealogy estimation for thousands of samples

(2019) Leo Speidel et al.   NATURE GENETICS

An approximate full-likelihood method for inferring selection and allele frequency trajectories from DNA sequence data

(2019) Aaron J. Stern et al.   PLoS Genetics

Polygenic Adaptation to an Environmental Shift: Temporal Dynamics of Variation Under Gaussian Stabilizing Selection and Additive Effects on a Single Trait

(2019) Kevin R. Thornton   GENETICS

Detecting Polygenic Adaptation in Admixture Graphs

(2018) Fernando Racimo et al.   GENETICS

Darwinian positive selection on the pleiotropic effects of KITLG explain skin pigmentation and winter temperature adaptation in Eurasians

(2018) Zhaohui Yang et al.   MOLECULAR BIOLOGY AND EVOLUTION

Signatures of negative selection in the genetic architecture of human complex traits

(2018) Jian Zeng et al.   NATURE GENETICS

Mixed-model association for biobank-scale datasets

(2018) Po-Ru Loh et al.   NATURE GENETICS

A population genetic interpretation of GWAS findings for human quantitative traits

(2018) Yuval B. Simons et al.   PLOS BIOLOGY

Detecting Polygenic Adaptation in Admixture Graphs

(2018) Fernando Racimo et al.   GENETICS

Relatedness disequilibrium regression estimates heritability without environmental bias

(2018) Alexander I. Young et al.   NATURE GENETICS

Reconstructing the History of Polygenic Scores Using Coalescent Trees

(2018) Michael D. Edge et al.   GENETICS

SLiM 3: Forward Genetic Simulations Beyond the Wright–Fisher Model

(2018) Benjamin C Haller et al.   MOLECULAR BIOLOGY AND EVOLUTION

Evidence of directional and stabilizing selection in contemporary humans

(2017) Jaleal S. Sanjak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data

(2016) Huwenbo Shi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Detection of human adaptation during the past 2000 years

(2016) Yair Field et al.   SCIENCE

Population genetic differentiation of height and body mass index across Europe

(2015) Matthew R Robinson et al.   NATURE GENETICS

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis

(2015) Po-Ru Loh et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Direct evidence for positive selection of skin, hair, and eye pigmentation in Europeans during the last 5,000 y

(2014) Sandra Wilde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Population Genetic Signal of Polygenic Adaptation

(2014) Jeremy J. Berg et al.   PLoS Genetics

Genome-Wide Inference of Ancestral Recombination Graphs

(2014) Matthew D. Rasmussen et al.   PLoS Genetics

Glycated Hemoglobin and Risk of Hypertension in the Atherosclerosis Risk in Communities Study

(2012) J. K. Bower et al.   DIABETES CARE

Evidence of widespread selection on standing variation in Europe at height-associated SNPs

(2012) Michael C Turchin et al.   NATURE GENETICS

Biomarkers in diabetes: hemoglobin A1c, vascular and tissue markers

(2012) Timothy J. Lyons et al.   Translational Research

The Genetics of Human Adaptation: Hard Sweeps, Soft Sweeps, and Polygenic Adaptation

(2010) Jonathan K. Pritchard et al.   CURRENT BIOLOGY

Hitchhiking Both Ways: Effect of Two Interfering Selective Sweeps on Linked Neutral Variation

(2008) L.-M. Chevin et al.   GENETICS

1000 Genomes project

(2008) Nayanah Siva   NATURE BIOTECHNOLOGY