NMPylation and de-NMPylation of SARS-CoV-2 nsp9 by the NiRAN domain

Coronavirus replication–transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit

(2021) Heiko Slanina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

(2021) Goran Kokic et al.   Nature Communications

Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP

(2021) Katerina Naydenova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD

(2021) Joel Fauser et al.   Nature Communications

Mass spectrometric based detection of protein nucleotidylation in the RNA polymerase of SARS-CoV-2

(2021) Brian J. Conti et al.   Communications Chemistry

Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets

(2021) Nunziata Maio et al.   SCIENCE

Allosteric Activation of SARS-CoV-2 RNA-Dependent RNA Polymerase by Remdesivir Triphosphate and Other Phosphorylated Nucleotides

(2021) Bing Wang et al.   mBio

Structure and function of SARS-CoV-2 polymerase

(2021) Hauke S Hillen   Current Opinion in Virology

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

Structural basis for RNA replication by the SARS-CoV-2 polymerase

(2020) Quan Wang et al.   CELL

Key features of magnesium that underpin its role as the major ion for electrophilic biocatalysis

(2020) Max E. Gottesman et al.   FEBS Journal

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

(2020) Calvin J. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of replicating SARS-CoV-2 polymerase

(2020) Hauke S. Hillen et al.   NATURE

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex

(2020) James Chen et al.   CELL

RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19

(2020) Yi Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Architecture of the SARS-CoV-2 Virus

(2020) Hangping Yao et al.   CELL

The coding capacity of SARS-CoV-2

(2020) Yaara Finkel et al.   NATURE

Characteristics of SARS-CoV-2 and COVID-19

(2020) Ben Hu et al.   NATURE REVIEWS MICROBIOLOGY

Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

(2020) Ashleigh Shannon et al.   Nature Communications

Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP

(2020) Zhen Zhao et al.   Cell Reports

Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis

(2020) Liming Yan et al.   CELL

Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting

(2020) Fran Robson et al.   MOLECULAR CELL

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase

(2020) Tyler L. Dangerfield et al.   iScience

The Mechanisms of Substrate Selection, Catalysis, and Translocation by the Elongating RNA Polymerase

(2019) Georgiy A. Belogurov et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

(2019) Robert N. Kirchdoerfer et al.   Nature Communications

RNA Synthesis and Capping by Non-segmented Negative Strand RNA Viral Polymerases: Lessons From a Prototypic Virus

(2019) Tomoaki Ogino et al.   Frontiers in Microbiology

A Comprehensive Superposition of Viral Polymerase Structures

(2019) Olve Peersen   Viruses-Basel

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

(2018) Anju Sreelatha et al.   CELL

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis—Binding of Foscarnet

(2016) Kalyan Das et al.   ACS Chemical Biology

Effect of Different Divalent Cations on the Kinetics and Fidelity of RB69 DNA Polymerase

(2016) Ashwani Kumar Vashishtha et al.   BIOCHEMISTRY

FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP

(2016) Steffen Preissler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP

(2016) Steffen Preissler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses

(2015) Kathleen C. Lehmann et al.   NUCLEIC ACIDS RESEARCH

In VitroCombination of Anti-Cytomegalovirus Compounds Acting through Different Targets: Role of the Slope Parameter and Insights into Mechanisms of Action

(2013) Hongyi Cai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu

(2013) Daniel Castro-Roa et al.   Nature Chemical Biology

NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase

(2013) Z. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Footprint of Genome Architecture in the Largest Genome Expansion in RNA Viruses

(2013) Chris Lauber et al.   PLoS Pathogens

RNA Transcript 3′-Proximal Sequence Affects Translocation Bias of RNA Polymerase

(2011) Pyae P. Hein et al.   BIOCHEMISTRY

Modulation of Rab GTPase function by a protein phosphocholine transferase

(2011) Shaeri Mukherjee et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Severe Acute Respiratory Syndrome Coronavirus nsp9 Dimerization Is Essential for Efficient Viral Growth

(2009) Z. J. Miknis et al.   JOURNAL OF VIROLOGY

Bisphosphonates: Mechanism of Action and Role in Clinical Practice

(2009) Matthew T. Drake et al.   MAYO CLINIC PROCEEDINGS