Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model

Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery

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Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

(2015) Anders Wittrup et al.   NATURE BIOTECHNOLOGY

Ionizable Amphiphilic Dendrimer-Based Nanomaterials with Alkyl-Chain-Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo

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Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models

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An overview of clinical and commercial impact of drug delivery systems

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Systemic Delivery of a miR34a Mimic as a Potential Therapeutic for Liver Cancer

(2014) C. L. Daige et al.   MOLECULAR CANCER THERAPEUTICS

Drug development: Try and try again

(2014) Megan Scudellari   NATURE

MicroRNA silencing for cancer therapy targeted to the tumour microenvironment

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Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

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(2014) Kathryn A. Whitehead et al.   Nature Communications

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Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery

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Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

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Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core

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Solid-Phase Synthesis of Sequence-Defined T-, i-, and U-Shape Polymers for pDNA and siRNA Delivery

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Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery

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“Click” methodologies: efficient, simple and greener routes to design dendrimers

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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Rational design of cationic lipids for siRNA delivery

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Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures

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Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

MicroRNAs and Cancer: Short RNAs Go a Long Way

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The role of let-7 in cell differentiation and cancer

(2009) Benjamin Boyerinas et al.   ENDOCRINE-RELATED CANCER

Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery

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Facile Synthesis of Polyester Dendrimers from Sequential Click Coupling of Asymmetrical Monomers

(2009) Xinpeng Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

New methodologies in the construction of dendritic materials

(2008) Anna Carlmark et al.   CHEMICAL SOCIETY REVIEWS

MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations

(2008) Yannick Ladeiro et al.   HEPATOLOGY

Robust, Efficient, and Orthogonal Synthesis of Dendrimers via Thiol-ene “Click” Chemistry

(2008) Kato L. Killops et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Sorafenib in Liver Cancer — Just the Beginning

(2008) Lewis R. Roberts   NEW ENGLAND JOURNAL OF MEDICINE

The let-7 family of microRNAs

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