标题
The trans-ancestral genomic architecture of glycemic traits
作者
关键词
-
出版物
NATURE GENETICS
Volume 53, Issue 6, Pages 840-860
出版商
Springer Science and Business Media LLC
发表日期
2021-06-01
DOI
10.1038/s41588-021-00852-9
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Variable prediction accuracy of polygenic scores within an ancestry group
- (2020) Hakhamanesh Mostafavi et al. eLife
- Identification of type 2 diabetes loci in 433,540 East Asian individuals
- (2020) Cassandra N. Spracklen et al. NATURE
- Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
- (2020) Marijana Vujkovic et al. NATURE GENETICS
- Tutorial: a guide to performing polygenic risk score analyses
- (2020) Shing Wan Choi et al. Nature Protocols
- Mendelian Randomization Analysis of Hemoglobin A1c as a Risk Factor for Coronary Artery Disease
- (2019) Aaron Leong et al. DIABETES CARE
- The influence of obesity-related factors in the etiology of renal cell carcinoma—A mendelian randomization study
- (2019) Mattias Johansson et al. PLOS MEDICINE
- Clinical use of current polygenic risk scores may exacerbate health disparities
- (2019) Alicia R. Martin et al. NATURE GENETICS
- GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals
- (2019) Valentina Iotchkova et al. NATURE GENETICS
- Polygenic prediction via Bayesian regression and continuous shrinkage priors
- (2019) Tian Ge et al. Nature Communications
- Analysis of polygenic risk score usage and performance in diverse human populations
- (2019) L. Duncan et al. Nature Communications
- Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine
- (2019) Miriam S Udler et al. ENDOCRINE REVIEWS
- Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program
- (2019) Chloé Sarnowski et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa
- (2019) Deepti Gurdasani et al. CELL
- Whole-Genome-Sequence-Based Haplotypes Reveal Single Origin of the Sickle Allele during the Holocene Wet Phase
- (2018) Daniel Shriner et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Fuzzy clustering in community detection based on nonnegative matrix factorization with two novel evaluation criteria
- (2018) Neda Binesh et al. APPLIED SOFT COMPUTING
- RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells
- (2018) Diana Guallar et al. NATURE GENETICS
- Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
- (2018) Jeanne E. Savage et al. NATURE GENETICS
- Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways
- (2018) Mats Nagel et al. NATURE GENETICS
- Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
- (2018) James J. Lee et al. NATURE GENETICS
- Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey
- (2018) Cassandra N. Spracklen et al. PLoS Genetics
- Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania
- (2018) Matt Ravenhall et al. PLoS Genetics
- TET2 facilitates PPARγ agonist–mediated gene regulation and insulin sensitization in adipocytes
- (2018) Fuyun Bian et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis
- (2018) Miriam S. Udler et al. PLOS MEDICINE
- Leveraging Polygenic Functional Enrichment to Improve GWAS Power
- (2018) Gleb Kichaev et al. AMERICAN JOURNAL OF HUMAN GENETICS
- An atlas of genetic associations in UK Biobank
- (2018) Oriol Canela-Xandri et al. NATURE GENETICS
- Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
- (2018) Anubha Mahajan et al. NATURE GENETICS
- Missing heritability: is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study
- (2017) Ilja M Nolte et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- TET-mediated hydroxymethylcytosine at the Pparγ locus is required for initiation of adipogenic differentiation
- (2017) Y Yoo et al. INTERNATIONAL JOURNAL OF OBESITY
- Genetic effects on gene expression across human tissues
- (2017) François Aguet et al. NATURE
- Genetic regulatory signatures underlying islet gene expression and type 2 diabetes
- (2017) Arushi Varshney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipid transport by TMEM24 at ER–plasma membrane contacts regulates pulsatile insulin secretion
- (2017) Joshua A. Lees et al. SCIENCE
- Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos
- (2017) Chani J. Hodonsky et al. PLoS Genetics
- Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
- (2017) Eleanor Wheeler et al. PLOS MEDICINE
- FINEMAP: efficient variable selection using summary data from genome-wide association studies
- (2016) Christian Benner et al. BIOINFORMATICS
- The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
- (2016) William J. Astle et al. CELL
- Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
- (2016) Geoffrey A. Walford et al. DIABETES
- African Ancestry–Specific Alleles and Kidney Disease Risk in Hispanics/Latinos
- (2016) Holly J. Kramer et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Identification of context-dependent expression quantitative trait loci in whole blood
- (2016) Daria V Zhernakova et al. NATURE GENETICS
- A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
- (2016) Robert A. Scott et al. Science Translational Medicine
- The genetic regulatory signature of type 2 diabetes in human skeletal muscle
- (2016) Laura J. Scott et al. Nature Communications
- Adjusting for Heritable Covariates Can Bias Effect Estimates in Genome-Wide Association Studies
- (2015) Hugues Aschard et al. AMERICAN JOURNAL OF HUMAN GENETICS
- GREGOR: evaluating global enrichment of trait-associated variants in epigenomic features using a systematic, data-driven approach
- (2015) Ellen M. Schmidt et al. BIOINFORMATICS
- Adrenocortical tumors and insulin resistance: What is the first step?
- (2015) Barbara Altieri et al. INTERNATIONAL JOURNAL OF CANCER
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- A global reference for human genetic variation
- (2015) Richard A. Gibbs et al. NATURE
- Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
- (2015) Kyle J Gaulton et al. NATURE GENETICS
- LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
- (2015) Brendan K Bulik-Sullivan et al. NATURE GENETICS
- Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
- (2015) Jennifer Wessel et al. Nature Communications
- PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling
- (2015) Laura Braccini et al. Nature Communications
- Biological interpretation of genome-wide association studies using predicted gene functions
- (2015) Tune H. Pers et al. Nature Communications
- Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
- (2015) Anubha Mahajan et al. PLoS Genetics
- Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation
- (2015) Momoko Horikoshi et al. PLoS Genetics
- Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors
- (2015) Martijn van de Bunt et al. PLoS Genetics
- Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits
- (2014) Joseph K. Pickrell AMERICAN JOURNAL OF HUMAN GENETICS
- Multiple Nonglycemic Genomic Loci Are Newly Associated With Blood Level of Glycated Hemoglobin in East Asians
- (2014) P. Chen et al. DIABETES
- Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
- (2014) Joo-Yeon Hwang et al. DIABETES
- The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease
- (2014) J. A. Bonomo et al. HUMAN MOLECULAR GENETICS
- Patients With Apparently Nonfunctioning Adrenal Incidentalomas May Be at Increased Cardiovascular Risk Due to Excessive Cortisol Secretion
- (2014) Ioannis I. Androulakis et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Focal epilepsy in Glucose transporter type 1 (Glut1) defects: case reports and a review of literature
- (2014) Stefan Wolking et al. JOURNAL OF NEUROLOGY
- Quality control and conduct of genome-wide association meta-analyses
- (2014) Thomas W Winkler et al. Nature Protocols
- Transcription Factor Ets1 Regulates Expression of Thioredoxin-Interacting Protein and Inhibits Insulin Secretion in Pancreatic β-Cells
- (2014) Yan Luo et al. PLoS One
- Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
- (2014) Beben Benyamin et al. Nature Communications
- Race/Ethnic Difference in Diabetes and Diabetic Complications
- (2013) Elias K. Spanakis et al. Current Diabetes Reports
- Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
- (2013) Antigone S. Dimas et al. DIABETES
- Systematic identification of trans eQTLs as putative drivers of known disease associations
- (2013) Harm-Jan Westra et al. NATURE GENETICS
- Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
- (2013) S. C. J. Parker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin Biosynthetic Interaction Network Component, TMEM24, Facilitates Insulin Reserve Pool Release
- (2013) Anita Pottekat et al. Cell Reports
- Insulin Resistance and Truncal Obesity as Important Determinants of the Greater Incidence of Diabetes in Indian Asians and African Caribbeans Compared With Europeans: The Southall And Brent REvisited (SABRE) cohort
- (2012) T. Tillin et al. DIABETES CARE
- Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications
- (2012) Evanthia Diamanti-Kandarakis et al. ENDOCRINE REVIEWS
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- (2012) NATURE GENETICS
- Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
- (2012) Robert A Scott et al. NATURE GENETICS
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
- (2012) Alisa K Manning et al. NATURE GENETICS
- Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
- (2012) Jian Yang et al. NATURE GENETICS
- ChromHMM: automating chromatin-state discovery and characterization
- (2012) Jason Ernst et al. NATURE METHODS
- Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
- (2012) Zari Dastani et al. PLoS Genetics
- The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits
- (2012) Benjamin F. Voight et al. PLoS Genetics
- Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance
- (2011) Mark O. Goodarzi et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals
- (2011) A. Nai et al. BLOOD
- Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk
- (2011) M. G. Rees et al. DIABETOLOGIA
- Transethnic meta-analysis of genomewide association studies
- (2011) Andrew P. Morris GENETIC EPIDEMIOLOGY
- Mapping and analysis of chromatin state dynamics in nine human cell types
- (2011) Jason Ernst et al. NATURE
- GCTA: A Tool for Genome-wide Complex Trait Analysis
- (2010) Jian Yang et al. AMERICAN JOURNAL OF HUMAN GENETICS
- METAL: fast and efficient meta-analysis of genomewide association scans
- (2010) C. J. Willer et al. BIOINFORMATICS
- Comparative Epigenomic Analysis of Murine and Human Adipogenesis
- (2010) Tarjei S. Mikkelsen et al. CELL
- Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways
- (2010) N. Soranzo et al. DIABETES
- MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
- (2010) Yun Li et al. GENETIC EPIDEMIOLOGY
- Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
- (2010) The Emerging Risk Factors Collaboration LANCET
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- (2010) Josée Dupuis et al. NATURE GENETICS
- Analyses and Comparison of Imputation-Based Association Methods
- (2010) Yu-Fang Pei et al. PLoS One
- Early Emergence of Ethnic Differences in Type 2 Diabetes Precursors in the UK: The Child Heart and Health Study in England (CHASE Study)
- (2010) Peter H. Whincup et al. PLOS MEDICINE
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