Transcription Factor Ets1 Regulates Expression of Thioredoxin-Interacting Protein and Inhibits Insulin Secretion in Pancreatic β-Cells

Thioredoxin-interacting Protein Promotes Islet Amyloid Polypeptide Expression through miR-124a and FoxA2

(2014) Gu Jing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin-Interacting Protein Stimulates Its Own Expression via a Positive Feedback Loop

(2014) Junqin Chen et al.   MOLECULAR ENDOCRINOLOGY

FOXO1 Competes with Carbohydrate Response Element-binding Protein (ChREBP) and Inhibits Thioredoxin-interacting Protein (TXNIP) Transcription in Pancreatic Beta Cells

(2013) Carly Kibbe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin-interacting protein regulates insulin transcription through microRNA-204

(2013) Guanlan Xu et al.   NATURE MEDICINE

Thioredoxin-Interacting Protein Gene Expression via MondoA Is Rapidly and Transiently Suppressed during Inflammatory Responses

(2013) Yasuyoshi Kanari et al.   PLoS One

Ets-1 facilitates nuclear entry of NFAT proteins and their recruitment to the IL-2 promoter

(2013) H.-W. Tsao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystallization and preliminary X-ray analysis of a complex of the FOXO1 and Ets1 DNA-binding domains and DNA

(2013) Wing W. Choy et al.   Acta Crystallographica Section F-Structural Biology Communications

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Disruption of Growth Factor Receptor-Binding Protein 10 in the Pancreas Enhances  -Cell Proliferation and Protects Mice From Streptozotocin-Induced  -Cell Apoptosis

(2012) J. Zhang et al.   DIABETES

Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity

(2012) N. Poungvarin et al.   DIABETOLOGIA

The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions

(2012) Mohammed Bensellam et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway

(2011) A. Lombardi et al.   DIABETOLOGIA

Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets

(2011) I. Goehring et al.   DIABETOLOGIA

Serum response factor expression is enriched in pancreatic β cells and regulates insulin gene expression

(2011) Aloke Sarkar et al.   FASEB JOURNAL

Decreasing Txnip mRNA and Protein Levels in Pancreatic MIN6 Cells Reduces Reactive Oxygen Species and Restores Glucose Regulated Insulin Secretion

(2010) Sweta Rani et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors

(2010) Madson Q. Almeida et al.   HUMAN MOLECULAR GENETICS

High glucose condition upregulated Txnip expression level in rat mesangial cells through ROS/MEK/MAPK pathway

(2010) Shaohong Fang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Glucose Controls Nuclear Accumulation, Promoter Binding, and Transcriptional Activity of the MondoA-Mlx Heterodimer

(2010) C. W. Peterson et al.   MOLECULAR AND CELLULAR BIOLOGY

Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP

(2010) M. L. Nelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity

(2010) Eiji Yoshihara et al.   Nature Communications

Involvement of ETS1 in thioredoxin-binding protein 2 transcription induced by a synthetic retinoid CD437 in human osteosarcoma cells

(2009) Koichi Hashiguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Involvement of Per-Arnt-Sim Kinase and Extracellular-Regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic  -Cells

(2009) G. Fontes et al.   DIABETES

Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid-Induced ER Stress-Mediated  -Cell Death

(2009) J. Chen et al.   DIABETES

Cooperative Activation of Npr1 Gene Transcription and Expression by Interaction of Ets-1 and p300

(2009) Prerna Kumar et al.   HYPERTENSION

Glucose-stimulated Expression of Txnip Is Mediated by Carbohydrate Response Element-binding Protein, p300, and Histone H4 Acetylation in Pancreatic Beta Cells

(2009) Hyunjoo Cha-Molstad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Thioredoxin-Interacting Protein: A Critical Link Between Glucose Toxicity and  -Cell Apoptosis

(2008) J. Chen et al.   DIABETES

Thioredoxin Binding Protein-2/Thioredoxin-Interacting Protein Is a Critical Regulator of Insulin Secretion and Peroxisome Proliferator-Activated Receptor Function

(2008) Shin-ichi Oka et al.   ENDOCRINOLOGY

Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes

(2008) Junqin Chen et al.   FASEB JOURNAL