A novel anti‐c‐Kit antibody–drug conjugate to treat wild‐type and activating‐mutant c‐Kit‐positive tumors

Preclinical Activity of PI3K Inhibitor Copanlisib in Gastrointestinal Stromal Tumor

(2020) Alfonso García-Valverde et al.   MOLECULAR CANCER THERAPEUTICS

Development and characterization of a fully human antibody targeting SCF/c-kit signaling

(2020) Jin-Ock Kim et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells

(2019) Maxine Bauzon et al.   OncoImmunology

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

(2019) Agnieszka Czechowicz et al.   Nature Communications

A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer

(2019) Elena Laura Mazzoldi et al.   Cell Death & Disease

SCF (Stem Cell Factor) and cKIT Modulate Pathological Ocular Neovascularization

(2019) Koung Li Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Atializumab, a humanized anti-aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) antibody significantly improves nephritis in (NZB/NZW) F1 mice

(2019) Chin Hee Mun et al.   BIOMATERIALS

Cancer Stem Cells and Neuroblastoma: Characteristics and Therapeutic Targeting Options

(2019) Veronica Veschi et al.   Frontiers in Endocrinology

Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase

(2019) Caroline Schoenherr et al.   PLoS One

Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies

(2018) Lawrence L'Italien et al.   CLINICAL CANCER RESEARCH

Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors

(2018) Tinya Abrams et al.   CLINICAL CANCER RESEARCH

Challenges and new frontiers in analytical characterization of antibody-drug conjugates

(2018) Anil Wagh et al.   mAbs

Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors

(2017) Y Obata et al.   ONCOGENE

Overexpression of the cancer stem cell marker CD117 predicts poor prognosis in epithelial ovarian cancer patients: evidence from meta-analysis

(2017) Bikang Yang et al.   OncoTargets and Therapy

CD117 expression is a predictive marker for poor prognosis in patients with non-small cell lung cancer

(2017) Tomohiko Sakabe et al.   Oncology Letters

CD98 signals controlling tumorigenesis

(2016) Hugh Ip et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells

(2016) Maryam Abbaspour Babaei et al.   Drug Design Development and Therapy

CD117+ cells in the circulation are predictive of advanced prostate cancer

(2015) Bethany A. Kerr et al.   Oncotarget

SCF, Regulated by HIF-1α, Promotes Pancreatic Ductal Adenocarcinoma Cell Progression

(2015) Chuntao Gao et al.   PLoS One

Stem Cell Factor Is a Potent Endothelial Permeability Factor

(2014) J. Y. Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antitumor Efficacy of a Bispecific Antibody That Targets HER2 and Activates T Cells

(2014) T. T. Junttila et al.   CANCER RESEARCH

Ponatinib Induces Apoptosis in Imatinib-Resistant Human Mast Cells by Dephosphorylating Mutant D816V KIT and Silencing  -Catenin Signaling

(2014) B. Jin et al.   MOLECULAR CANCER THERAPEUTICS

Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation

(2014) Yuuki Obata et al.   Nature Communications

Imatinib sensitizes endometrial cancer cells to cisplatin by targeting CD117-positive growth-competent cells

(2013) Xiuzhi Zhang et al.   CANCER LETTERS

Estimation of rat mammary tumor volume using caliper and ultrasonography measurements

(2013) Ana Faustino-Rocha et al.   LAB ANIMAL

Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth

(2013) Badreddin Edris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability

(2013) Kirsten Achilles Poon et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/β-catenin–ATP-binding cassette G2 signaling

(2012) W K Chau et al.   ONCOGENE

Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications

(2012) Johan Lennartsson et al.   PHYSIOLOGICAL REVIEWS

p53 Modulation as a Therapeutic Strategy in Gastrointestinal Stromal Tumors

(2012) Joern Henze et al.   PLoS One

Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION)

(2011) H. M. Kantarjian et al.   BLOOD

Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome

(2011) Lijing Luo et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

KIT as a Therapeutic Target in Metastatic Melanoma

(2011) Richard D. Carvajal   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CD117 and Stro-1 Identify Osteosarcoma Tumor-Initiating Cells Associated with Metastasis and Drug Resistance

(2010) Amit S. Adhikari et al.   CANCER RESEARCH

Elimination of Human Lung Cancer Stem Cells through Targeting of the Stem Cell Factor-c-kit Autocrine Signaling Loop

(2009) V. Levina et al.   CANCER RESEARCH

Resistance to Tyrosine Kinase Inhibitors in Gastrointestinal Stromal Tumors

(2009) A. W. Gramza et al.   CLINICAL CANCER RESEARCH

The D816V Mutation of c-Kit Circumvents a Requirement for Src Family Kinases in c-Kit Signal Transduction

(2009) Jianmin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Higher susceptibility of NOG mice to xenotransplanted tumors

(2009) Kazuhiko Machida et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Multitargeted tyrosine kinase inhibitor stimulates expression of IL-6 and activates JAK2/STAT5 signaling in acute myelogenous leukemia cells

(2009) C Nishioka et al.   LEUKEMIA

The Aberrant Localization of Oncogenic Kit Tyrosine Kinase Receptor Mutants Is Reversed on Specific Inhibitory Treatment

(2009) H. Bougherara et al.   MOLECULAR CANCER RESEARCH

Gab2 Is Involved in Differential Phosphoinositide 3-Kinase Signaling by Two Splice Forms of c-Kit

(2008) Jianmin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterogeneity of kinase inhibitor resistance mechanisms in GIST

(2008) B Liegl et al.   JOURNAL OF PATHOLOGY