Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors

Constitutive activation of oncogenic PDGFRα-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRα signalling characteristics

(2015) Christelle Bahlawane et al.   Cell Communication and Signaling

Combined Inhibition of MAP Kinase and KIT Signaling Synergistically Destabilizes ETV1 and Suppresses GIST Tumor Growth

(2015) L. Ran et al.   Cancer Discovery

Synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M involves Rab11-dependent EGFR recycling

(2014) Zenta Watanuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering

(2014) Dan Fu et al.   Nature Chemistry

Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation

(2014) Yuuki Obata et al.   Nature Communications

Oncogenic deletion mutants of gp130 signal from intracellular compartments

(2013) D. Schmidt-Arras et al.   JOURNAL OF CELL SCIENCE

Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia

(2013) Shunsuke Kon et al.   JOURNAL OF CLINICAL INVESTIGATION

KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570

(2013) A Chaix et al.   ONCOGENE

Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth

(2013) Badreddin Edris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications

(2012) Johan Lennartsson et al.   PHYSIOLOGICAL REVIEWS

Imatinib resistance and microcytic erythrocytosis in a KitV558 ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor

(2012) B. Bosbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gastrointestinal stromal tumors (GISTs): role of CD 117 and PDGFRA Golgi-like staining pattern in the recognition of mutational status

(2012) Sara Jaramillo et al.   REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS

Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

(2011) Lisa von Kleist et al.   CELL

Balanced Interactions between Lyn, the p85  Regulatory Subunit of Class IA Phosphatidylinositol-3-Kinase, and SHIP Are Essential for Mast Cell Growth and Maturation

(2011) P. Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

A direct role for Met endocytosis in tumorigenesis

(2011) Carine Joffre et al.   NATURE CELL BIOLOGY

New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases

(2010) F. Toffalini et al.   BLOOD

Role for the Proapoptotic Factor BIM in Mediating Imatinib-induced Apoptosis in a c-KIT-dependent Gastrointestinal Stromal Tumor Cell Line

(2010) Peter M. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours

(2010) Ping Chi et al.   NATURE

Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src@

(2009) Byung Chung et al.   BMC CELL BIOLOGY

The Aberrant Localization of Oncogenic Kit Tyrosine Kinase Receptor Mutants Is Reversed on Specific Inhibitory Treatment

(2009) H. Bougherara et al.   MOLECULAR CANCER RESEARCH

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

(2009) Chunaram Choudhary et al.   MOLECULAR CELL

Dotlike or Golgi-like KIT and PDGFRA Staining in GISTs

(2008) Jean-François Emile et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor

(2008) Toshirou Nishida et al.   CANCER SCIENCE

KIT Mutations Induce Intracellular Retention and Activation of an Immature Form of the KIT Protein in Gastrointestinal Stromal Tumors

(2008) S. Tabone-Eglinger et al.   CLINICAL CANCER RESEARCH

Clinical significance of oncogenicKITandPDGFRAmutations in gastrointestinal stromal tumours

(2008) J Lasota et al.   HISTOPATHOLOGY

A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway

(2008) Teodoro Pulvirenti et al.   NATURE CELL BIOLOGY

Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity

(2008) M Scaltriti et al.   ONCOGENE