Challenges and new frontiers in analytical characterization of antibody-drug conjugates
出版年份 2018 全文链接
标题
Challenges and new frontiers in analytical characterization of antibody-drug conjugates
作者
关键词
-
出版物
mAbs
Volume 10, Issue 2, Pages 222-243
出版商
Informa UK Limited
发表日期
2018-01-03
DOI
10.1080/19420862.2017.1412025
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- High resolution separations of charge variants and disulfide isomers of monoclonal antibodies and antibody drug conjugates using ultra-high voltage capillary electrophoresis with high electric field strength
- (2017) W. Hampton Henley et al. JOURNAL OF CHROMATOGRAPHY A
- Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates
- (2017) Thomas Botzanowski et al. mAbs
- Strategies and challenges for the next generation of antibody–drug conjugates
- (2017) Alain Beck et al. NATURE REVIEWS DRUG DISCOVERY
- Gemtuzumab Ozogamicin Makes a Comeback
- (2017) Cancer Discovery
- Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality Control
- (2017) Yubo Tang et al. Scientific Reports
- Structural characterization of antibody drug conjugate by a combination of intact, middle-up and bottom-up techniques using sheathless capillary electrophoresis – Tandem mass spectrometry as nanoESI infusion platform and separation method
- (2016) Nassur Said et al. ANALYTICA CHIMICA ACTA
- Characterization of Intact Antibody Drug Conjugate Variants Using Microfluidic Capillary Electrophoresis–Mass Spectrometry
- (2016) Erin A. Redman et al. ANALYTICAL CHEMISTRY
- Antibody drug conjugates: lessons from 20 years of clinical experience
- (2016) A. W. Tolcher ANNALS OF ONCOLOGY
- Cathepsin B Cleavage of vcMMAE-Based Antibody–Drug Conjugate Is Not Drug Location or Monoclonal Antibody Carrier Specific
- (2016) Benson Gikanga et al. BIOCONJUGATE CHEMISTRY
- Characterization and Higher-Order Structure Assessment of an Interchain Cysteine-Based ADC: Impact of Drug Loading and Distribution on the Mechanism of Aggregation
- (2016) Jianxin Guo et al. BIOCONJUGATE CHEMISTRY
- Antibody-drug conjugates—an emerging class of cancer treatment
- (2016) Nikolaos Diamantis et al. BRITISH JOURNAL OF CANCER
- Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates
- (2016) Alain Beck et al. Expert Review of Proteomics
- Analysis of antibody-drug conjugates by comprehensive on-line two-dimensional hydrophobic interaction chromatography x reversed phase liquid chromatography hyphenated to high resolution mass spectrometry. I − Optimization of separation conditions
- (2016) Morgan Sarrut et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Investigation of low recovery in the free drug assay for antibody drug conjugates by size exclusion—reversed phase two dimensional-liquid chromatography
- (2016) Yi Li et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Multiple heart-cutting and comprehensive two-dimensional liquid chromatography hyphenated to mass spectrometry for the characterization of the antibody-drug conjugate ado-trastuzumab emtansine
- (2016) Koen Sandra et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- A simple LC/MRM–MS-based method to quantify free linker-payload in antibody-drug conjugate preparations
- (2016) Wesley Zmolek et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Physical and Chemical Stability of Antibody Drug Conjugates: Current Status
- (2016) Philip L. Ross et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Antibodies to watch in 2017
- (2016) Janice M. Reichert mAbs
- RP-HPLC DAR Characterization of Site-Specific Antibody Drug Conjugates Produced in a Cell-Free Expression System
- (2016) Yiren Xu et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Antibody-drug conjugates: Current status and future perspectives
- (2016) Rémy Gébleux et al. PHARMACOLOGY & THERAPEUTICS
- Early Patient Access to Medicines: Health Technology Assessment Bodies Need to Catch Up with New Marketing Authorization Methods
- (2016) Lada Leyens et al. Public Health Genomics
- Unconjugated payload quantification and DAR characterization of antibody–drug conjugates using high-resolution MS
- (2016) Leanne Grafmuller et al. Bioanalysis
- Calculated conjugated payload from immunoassay and LC–MS intact protein analysis measurements of antibody-drug conjugate
- (2016) Brian Rago et al. Bioanalysis
- Antibody Drug Conjugates: Design and Selection of Linker, Payload and Conjugation Chemistry
- (2015) Jessica R. McCombs et al. AAPS Journal
- Tandem Native Mass-Spectrometry on Antibody–Drug Conjugates and Submillion Da Antibody–Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector
- (2015) Andrey Dyachenko et al. ANALYTICAL CHEMISTRY
- A size exclusion-reversed phase two dimensional-liquid chromatography methodology for stability and small molecule related species in antibody drug conjugates
- (2015) Yi Li et al. JOURNAL OF CHROMATOGRAPHY A
- Characterization of antibody drug conjugate positional isomers at cysteine residues by peptide mapping LC–MS analysis
- (2015) Marie-Claire Janin-Bussat et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Characterization of Cysteine-Linked Conjugation Profiles of Immunoglobulin G1 and Immunoglobulin G2 Antibody–Drug Conjugates
- (2015) Brian Wiggins et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- A rapid on-line method for mass spectrometric confirmation of a cysteine-conjugated antibody-drug-conjugate structure using multidimensional chromatography
- (2015) Robert E Birdsall et al. mAbs
- Antibody–Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs
- (2015) Christopher R. Behrens et al. MOLECULAR PHARMACEUTICS
- Maytansinoid–BODIPY Conjugates: Application to Microscale Determination of Drug Extinction Coefficients and for Quantification of Maytansinoid Analytes
- (2015) Nathan Fishkin MOLECULAR PHARMACEUTICS
- Photoinduced Aggregation of a Model Antibody–Drug Conjugate
- (2015) Gregory M. Cockrell et al. MOLECULAR PHARMACEUTICS
- Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index
- (2015) Robert P Lyon et al. NATURE BIOTECHNOLOGY
- Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading
- (2015) Pavel Strop et al. NATURE BIOTECHNOLOGY
- Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate
- (2015) Julien Marcoux et al. PROTEIN SCIENCE
- Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy
- (2015) Magdalena Dorywalska et al. PLoS One
- Ado-trastuzumab Emtansine
- (2014) Patricia A. Corrigan et al. ANNALS OF PHARMACOTHERAPY
- Auristatin Antibody Drug Conjugate Physical Instability and the Role of Drug Payload
- (2014) Yilma T. Adem et al. BIOCONJUGATE CHEMISTRY
- Statistical Modeling of the Drug Load Distribution on Trastuzumab Emtansine (Kadcyla), a Lysine-Linked Antibody Drug Conjugate
- (2014) Michael T. Kim et al. BIOCONJUGATE CHEMISTRY
- Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
- (2014) R. Cohen et al. CANCER RESEARCH
- Gemtuzumab ozogamicin in acute myeloid leukemia revisited
- (2014) Felicitas Thol et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Assessment of Physical Stability of an Antibody Drug Conjugate by Higher Order Structure Analysis: Impact of Thiol- Maleimide Chemistry
- (2014) Jianxin Guo et al. PHARMACEUTICAL RESEARCH
- A general approach to site-specific antibody drug conjugates
- (2014) Feng Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Monoclonal Antibodies in Cancer Therapy: Mechanisms, Successes and Limitations
- (2014) A Coulson et al. WEST INDIAN MEDICAL JOURNAL
- Development of a Native Nanoelectrospray Mass Spectrometry Method for Determination of the Drug-to-Antibody Ratio of Antibody–Drug Conjugates
- (2013) Jia Chen et al. ANALYTICAL CHEMISTRY
- Conjugation Site Heterogeneity Causes Variable Electrostatic Properties in Fc Conjugates
- (2013) Nicholas J. Boylan et al. BIOCONJUGATE CHEMISTRY
- Mass Spectrometric Characterization of Transglutaminase Based Site-Specific Antibody–Drug Conjugates
- (2013) Santiago E. Farias et al. BIOCONJUGATE CHEMISTRY
- Site-specific antibody drug conjugates for cancer therapy
- (2013) Siler Panowski et al. mAbs
- Methods for site-specific drug conjugation to antibodies
- (2013) Christopher R Behrens et al. mAbs
- Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion
- (2013) Elsa Wagner-Rousset et al. mAbs
- Maturing antibody–drug conjugate pipeline hits 30
- (2013) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Antibody–drug conjugates
- (2013) Rachel S. Zolot et al. NATURE REVIEWS DRUG DISCOVERY
- Protein Particulate Detection Issues in Biotherapeutics Development—Current Status
- (2012) Tapan K. Das AAPS PHARMSCITECH
- Brentuximab vedotin in Hodgkin's lymphoma
- (2012) Barbara Pro et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Ultra-high voltage capillary electrophoresis >300kV: Recent advances in instrumentation and analyte detection
- (2012) W. Hampton Henley et al. JOURNAL OF CHROMATOGRAPHY A
- Impact of linker and conjugation chemistry on antigen binding, Fc receptor binding and thermal stability of model antibody-drug conjugates
- (2012) Mauro Acchione et al. mAbs
- A Pictet-Spengler ligation for protein chemical modification
- (2012) P. Agarwal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthesis of site-specific antibody-drug conjugates using unnatural amino acids
- (2012) J. Y. Axup et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats
- (2011) C. Andrew Boswell et al. BIOCONJUGATE CHEMISTRY
- Identification of Amino Acid Residues Responsible for the Release of Free Drug from an Antibody–Drug Conjugate Utilizing Lysine–Succinimidyl Ester Chemistry
- (2011) Hung-Wei Chih et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Fragmentation of monoclonal antibodies
- (2011) Josef Vlasak et al. mAbs
- Analytical methods for physicochemical characterization of antibody drug conjugates
- (2011) Aditya Wakankar et al. mAbs
- Site-Specific and Stoichiometric Modification of Antibodies by Bacterial Transglutaminase
- (2010) Simone Jeger et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Physicochemical Stability of the Antibody−Drug Conjugate Trastuzumab-DM1: Changes due to Modification and Conjugation Processes
- (2010) Aditya A. Wakankar et al. BIOCONJUGATE CHEMISTRY
- Charge variants in IgG1
- (2010) Leslie A. Khawli et al. mAbs
- Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies
- (2009) Laurent Ducry et al. BIOCONJUGATE CHEMISTRY
- Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates
- (2008) Stephen C. Alley et al. BIOCONJUGATE CHEMISTRY
- Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
- (2008) Jagath R Junutula et al. NATURE BIOTECHNOLOGY
- Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs
- (2007) Ravi V. J. Chari ACCOUNTS OF CHEMICAL RESEARCH
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More