Inflammation and Alzheimer’s Disease: Mechanisms and Therapeutic Implications by Natural Products

Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals

(2020) Andleeb Khan et al.   Biomedicines

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy

(2020) Yutong Zhou et al.   Science Advances

Curcumin reduces inflammation in knee osteoarthritis rats through blocking TLR4 /MyD88/NF-κB signal pathway

(2019) Yun Zhang et al.   DRUG DEVELOPMENT RESEARCH

Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases

(2019) Cinzia Forni et al.   Biomed Research International

STAT3: A Potential Drug Target for Tumor and Inflammation

(2019) Yang Sheng Hu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis

(2019) B. Teter et al.   NEUROBIOLOGY OF DISEASE

Olfactory Ensheathing Cells Grafted Into the Retina of RCS Rats Suppress Inflammation by Down-Regulating the JAK/STAT Pathway

(2019) Jing Xie et al.   Frontiers in Cellular Neuroscience

Anti-fibrotic effects of curcumin and some of its analogues in the heart

(2019) Armita Mahdavi Gorabi et al.   HEART FAILURE REVIEWS

Curcumin Protects Human Umbilical Vein Endothelial Cells against H2O2-Induced Cell Injury

(2019) Jipeng Ouyang et al.   Pain Research & Management

Neuroinflammation as a Common Feature of Neurodegenerative Disorders

(2019) Leonardo Guzman-Martinez et al.   Frontiers in Pharmacology

JAK/STAT Signal Transduction: Promising Attractive Targets for Immune, Inflammatory and Hematopoietic Diseases

(2018) Qianwen Gao et al.   CURRENT DRUG TARGETS

Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment

(2018) Dunja Knezevic et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A Combination Cocktail Improves Spatial Attention in a Canine Model of Human Aging and Alzheimer's Disease

(2018) Elizabeth Head et al.   JOURNAL OF ALZHEIMERS DISEASE

Mediterranean Diet and Cognitive Decline. A Lesson from the Whole-Diet Approach: What Challenges Lie Ahead?

(2018) Vincenzo Solfrizzi et al.   JOURNAL OF ALZHEIMERS DISEASE

Amelioration of Aluminum Maltolate-Induced Inflammation and Endoplasmic Reticulum Stress-Mediated Apoptosis by Tannoid Principles of Emblica officinalis in Neuronal Cellular Model

(2018) Mathiyazahan Dhivya Bharathi et al.   NEUROTOXICITY RESEARCH

Protective effects of curcumin against ischemia-reperfusion injury in the liver

(2018) Kowsar Bavarsad et al.   PHARMACOLOGICAL RESEARCH

Naringenin reduces oxidative stress and improves mitochondrial dysfunction via activation of the Nrf2/ARE signaling pathway in neurons

(2017) Kaihua Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer’s disease

(2017) Lina Clara Gayoso e Ibiapina Moreno et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Aging increases cell-to-cell transcriptional variability upon immune stimulation

(2017) Celia Pilar Martinez-Jimenez et al.   SCIENCE

Spatial and Temporal Control of Senescence

(2017) Yoko Ito et al.   TRENDS IN CELL BIOLOGY

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a

(2017) Ali M. El Halawany et al.   Scientific Reports

Green Tea Extracts Epigallocatechin-3-gallate for Different Treatments

(2017) Chenyu Chu et al.   Biomed Research International

Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans

(2017) Simon Vann Jones et al.   Frontiers in Immunology

Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer’s mouse model by controlling β-amyloid production

(2017) Sandra Colié et al.   Scientific Reports

Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain

(2016) Katarzyna Popiolek-Barczyk et al.   CURRENT MEDICINAL CHEMISTRY

Aging of the immune system: Focus on inflammation and vaccination

(2016) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Antioxidant Effects of Thymoquinone in Activated BV-2 Murine Microglial Cells

(2016) Makini K. Cobourne-Duval et al.   NEUROCHEMICAL RESEARCH

Functions of flavonoids in the central nervous system: Astrocytes as targets for natural compounds

(2016) Isadora Matias et al.   NEUROCHEMISTRY INTERNATIONAL

Protection against β-amyloid-induced neurotoxicity by naturally occurring Z-ligustilide through the concurrent regulation of p38 and PI3-K/Akt pathways

(2016) Wei Xu et al.   NEUROCHEMISTRY INTERNATIONAL

Dietary pattern and antioxidants in plasma and erythrocyte in patients with mild cognitive impairment from China

(2016) Linhong Yuan et al.   NUTRITION

Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases

(2016) Robert Roskoski   PHARMACOLOGICAL RESEARCH

The Curcumin Analog C-150, Influencing NF-κB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo

(2016) László Hackler et al.   PLoS One

Targeting arachidonic acid pathway by natural products for cancer prevention and therapy

(2016) Nagendra Sastry Yarla et al.   SEMINARS IN CANCER BIOLOGY

Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes

(2016) Kyu-Ho Han   WORLD JOURNAL OF GASTROENTEROLOGY

Drug development in Alzheimer’s disease: the path to 2025

(2016) Jeffrey Cummings et al.   Alzheimers Research & Therapy

Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease

(2016) Zun-Jing Liu et al.   Frontiers in Pharmacology

Anti-inflammatory effect of resveratrol through the suppression of NF- B and JAK/STAT signaling pathways

(2015) C. Ma et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Hippocampal neuronal cyclooxygenase-2 downstream signaling imbalance in a rat model of chronic aluminium gluconate administration

(2015) Hong Wang et al.   Behavioral and Brain Functions

Flavonoids at the pharma-nutrition interface: Is a therapeutic index in demand?

(2015) Ilaria Peluso et al.   BIOMEDICINE & PHARMACOTHERAPY

Association of flavonoid-rich foods and statins in the management of hypercholesterolemia: a dangerous or helpful combination?

(2015) Ilaria Peluso et al.   CURRENT DRUG METABOLISM

The Role of Neuroinflammation in Dementias

(2015) Giuseppe Pasqualetti et al.   Current Neurology and Neuroscience Reports

Reactive Oxygen Species, Redox Signaling and Neuroinflammation in Alzheimer's Disease: The NF-κB Connection

(2015) Upinder Kaur et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Age-associated B cells: key mediators of both protective and autoreactive humoral responses

(2015) Martin S. Naradikian et al.   IMMUNOLOGICAL REVIEWS

The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases

(2015) L. Ben Haim et al.   JOURNAL OF NEUROSCIENCE

Intranasal Piperine-Loaded Chitosan Nanoparticles as Brain-Targeted Therapy in Alzheimer's Disease: Optimization, Biological Efficacy, and Potential Toxicity

(2015) Yosra S.R. Elnaggar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Effect of hesperidin on neurobehavioral, neuroinflammation, oxidative stress and lipid alteration in intracerebroventricular streptozotocin induced cognitive impairment in mice

(2015) Hayate Javed et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

(2015) Giuseppe Verdile et al.   MEDIATORS OF INFLAMMATION

Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases

(2015) Yu-Jie Zhang et al.   MOLECULES

A multi-targeted approach to suppress tumor-promoting inflammation

(2015) Abbas K. Samadi et al.   SEMINARS IN CANCER BIOLOGY

Post-mortem analysis of neuroinflammatory changes in human Alzheimer’s disease

(2015) Diego Gomez-Nicola et al.   Alzheimers Research & Therapy

Tau aggregation and its interplay with amyloid-β

(2014) Rebecca M. Nisbet et al.   ACTA NEUROPATHOLOGICA

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

(2014) Sergio T. Ferreira et al.   Alzheimers & Dementia

Apelin is transcriptionally regulated by ER stress-induced ATF4 expression via a p38 MAPK-dependent pathway

(2014) Kwon Jeong et al.   APOPTOSIS

Astrocytes and neuroinflammation in Alzheimer's disease

(2014) Emma C. Phillips et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Hesperidin Alleviates Cognitive Impairment, Mitochondrial Dysfunction and Oxidative Stress in a Mouse Model of Alzheimer’s Disease

(2014) Dongmei Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Serum Cytokine Profile in Alzheimer's Disease Patients After Ingestion of an Antioxidant Beverage

(2014) J.M. Rubio-Perez et al.   CNS & Neurological Disorders-Drug Targets

Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL/6J and Triple Transgenic Alzheimer’s Mice

(2014) Hei-Jen Huang et al.   Evidence-based Complementary and Alternative Medicine

Antioxidative Dietary Compounds Modulate Gene Expression Associated with Apoptosis, DNA Repair, Inhibition of Cell Proliferation and Migration

(2014) Likui Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Curcumin (Curcuma longa) on Learning and Spatial Memory as Well as Cell Proliferation and Neuroblast Differentiation in Adult and Aged Mice by Upregulating Brain-Derived Neurotrophic Factor and CREB Signaling

(2014) Sung Min Nam et al.   JOURNAL OF MEDICINAL FOOD

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alzheimer’s and ABC transporters — new opportunities for diagnostics and treatment

(2014) Jens Pahnke et al.   NEUROBIOLOGY OF DISEASE

Do Astrocytes Collaborate with Neurons in Spreading the “Infectious” Aβ and Tau Drivers of Alzheimer’s Disease?

(2014) Ilaria Dal Prà et al.   NEUROSCIENTIST

Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?

(2014) Torbjörn Persson et al.   Oxidative Medicine and Cellular Longevity

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

(2014) Ian M. Copple et al.   TOXICOLOGICAL SCIENCES

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

(2014) Inelia Morales et al.   Frontiers in Cellular Neuroscience

Raised Serum Proinflammatory Cytokines in Alzheimer's Disease with Depression

(2014)   Aging and Disease

Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer’s Disease Model via Canonical Wnt/β-Catenin Pathway

(2013) Shashi Kant Tiwari et al.   ACS Nano

The Possible Role of Antioxidant Vitamin C in Alzheimer’s Disease Treatment and Prevention

(2013) Jae-Hyeok Heo et al.   American Journal of Alzheimers Disease and Other Dementias

Effects of naringenin and its phase II metabolites onin vitrohuman macrophage gene expression

(2013) Margherita Dall’Asta et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

1,8-Cineole (Eucalyptol) Mitigates Inflammation in Amyloid Beta Toxicated PC12 Cells: Relevance to Alzheimer’s Disease

(2013) Andleeb Khan et al.   NEUROCHEMICAL RESEARCH

Amelioration of cognitive impairment and neurodegeneration by catechin hydrate in rat model of streptozotocin-induced experimental dementia of Alzheimer’s type

(2013) Md. Ejaz Ahmed et al.   NEUROCHEMISTRY INTERNATIONAL

Fisetin Enhances Behavioral Performances and Attenuates Reactive Gliosis and Inflammation During Aluminum Chloride-Induced Neurotoxicity

(2013) Dharmalingam Prakash et al.   NEUROMOLECULAR MEDICINE

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

(2013) Grietje Krabbe et al.   PLoS One

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

(2013) V. Hugh Perry et al.   Seminars in Immunopathology

Advances with RNA interference in Alzheimer’s disease research

(2013) Weien Yuan et al.   Drug Design Development and Therapy

Role of ABC Transporters in the Pathogenesis of Alzheimer’s Disease

(2012) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis

(2012) Rui Liu et al.   BMC Medicine

Oligomers of beta-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain

(2012) I. Carrero et al.   EXPERIMENTAL NEUROLOGY

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Attenuation of Aβ-induced neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress

(2012) Andleeb Khan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Amyloid precursor protein (APP) regulates synaptic structure and function

(2012) Sheue-Houy Tyan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Preconditioning with Ginkgo biloba (EGb 761®) provides neuroprotection through HO1 and CRMP2

(2012) Shadia E. Nada et al.   NEUROBIOLOGY OF DISEASE

Antioxidant Therapies for Alzheimer's Disease

(2012) Ye Feng et al.   Oxidative Medicine and Cellular Longevity

Neuropathological Similarities and Differences between Schizophrenia and Bipolar Disorder: A Flow Cytometric Postmortem Brain Study

(2012) Yoshitaka Hayashi et al.   PLoS One

Reduced Myelin Basic Protein and Actin-Related Gene Expression in Visual Cortex in Schizophrenia

(2012) Paul R. Matthews et al.   PLoS One

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

(2011) Robert J. Williams et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction

(2011) Maya K. Desai et al.   GLIA

Amyloid-β-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia

(2011) Tom Schilling et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Complement in the brain

(2011) Robert Veerhuis et al.   MOLECULAR IMMUNOLOGY

Caspase signalling controls microglia activation and neurotoxicity

(2011) Miguel A. Burguillos et al.   NATURE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Proinflammatory cytokines, sickness behavior, and Alzheimer disease

(2011) C. Holmes et al.   NEUROLOGY

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

The neuroprotective role of boric acid on aluminum chloride-induced neurotoxicity

(2011) Suat Çolak et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

(2011) Seth L. Masters et al.   TRENDS IN MOLECULAR MEDICINE

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

(2011) C J Garwood et al.   Cell Death & Disease

Focal demyelination in Alzheimer’s disease and transgenic mouse models

(2010) Stanislaw Mitew et al.   ACTA NEUROPATHOLOGICA

Regulation of NF-E2-Related Factor 2 Signaling for Cancer Chemoprevention: Antioxidant Coupled with Antiinflammatory

(2010) Rong Hu et al.   ANTIOXIDANTS & REDOX SIGNALING

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Macrophage Colony-Stimulating Factor (M-CSF) in Plasma and CSF of Patients with Mild Cognitive Impairment and Alzheimers Disease

(2010) C. Laske et al.   Current Alzheimer Research

CCL2 modulates cytokine production in cultured mouse astrocytes

(2010) Bridgette D Semple et al.   Journal of Neuroinflammation

Tyk2/STAT3 Signaling Mediates  -Amyloid-Induced Neuronal Cell Death: Implications in Alzheimer's Disease

(2010) J. Wan et al.   JOURNAL OF NEUROSCIENCE

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Alzheimer's Disease and tauopathy studies in flies and worms

(2010) Jill Wentzell et al.   NEUROBIOLOGY OF DISEASE

β-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain

(2010) Erica Buoso et al.   PHARMACOLOGICAL RESEARCH

Nuclear factor- B is a critical mediator of stress-impaired neurogenesis and depressive behavior

(2010) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel insights for the treatment of Alzheimer's disease

(2010) Alexander Kurz et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Oligodendrocytes: biology and pathology

(2009) Monika Bradl et al.   ACTA NEUROPATHOLOGICA

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Interferon-γ Differentially Affects Alzheimer’s Disease Pathologies and Induces Neurogenesis in Triple Transgenic-AD Mice

(2009) Michael A. Mastrangelo et al.   AMERICAN JOURNAL OF PATHOLOGY

Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells

(2009) María Monagas et al.   BRITISH JOURNAL OF NUTRITION

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria

(2009) Lobelia Samavati et al.   MOLECULAR IMMUNOLOGY

Allele-specific RNAi Mitigates Phenotypic Progression in a Transgenic Model of Alzheimer's Disease

(2009) Edgardo Rodríguez-Lebrón et al.   MOLECULAR THERAPY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

CCR5 deficiency induces astrocyte activation, Aβ deposit and impaired memory function

(2009) Yong Kyoung Lee et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

(2008) Michelle C. Janelsins et al.   AMERICAN JOURNAL OF PATHOLOGY

Thiol-Based Redox Switches in Eukaryotic Proteins

(2008) Nicolas Brandes et al.   ANTIOXIDANTS & REDOX SIGNALING

A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro

(2008) Sunita Suri et al.   BIOCHEMICAL PHARMACOLOGY

Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor   Agonist

(2008) N. Nicolakakis et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease

(2008) A. N. Begum et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

c-Rel, an NF- B family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation

(2008) H. J. Ahn et al.   LEARNING & MEMORY

Amyloid-β causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons

(2008) T Chiba et al.   MOLECULAR PSYCHIATRY

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Activation of MKK6, an upstream activator of p38, in Alzheimer's disease

(2003) Xiongwei Zhu et al.   JOURNAL OF NEUROCHEMISTRY