Article
Biochemistry & Molecular Biology
Buyun Kim, Ki Yong Lee, Byoungduck Park
Summary: Alzheimer's disease is a severe neurodegenerative disorder characterized by distinct pathological features. The nuclear factor-κB plays a crucial role in neuronal inflammation. Isoorientin (ISO) shows potential as a promising therapeutic drug candidate for the treatment and prevention of AD.
Review
Biochemistry & Molecular Biology
Bhagavathi Sundaram Sivamaruthi, Neha Raghani, Mehul Chorawala, Sankha Bhattacharya, Bhupendra G. Prajapati, Gehan M. Elossaily, Chaiyavat Chaiyasut
Summary: The NF-kappa B pathway plays a crucial role in various diseases, including Alzheimer's disease. It has the potential to mitigate neuroinflammation, modulate amyloid beta production, and promote neuronal survival in the progression of Alzheimer's disease. However, there are limitations and challenges associated with this approach, as balancing inflammation inhibition and preserving physiological immune responses is critical.
Article
Neurosciences
Rui Chen, Ziyu Wang, Zhongwen Zhi, Jisha Tian, Ying Zhao, Junshan Sun
Summary: Oxysophoridine suppresses A beta-induced oxidative stress and inflammation in BV-2 cells by inhibiting the TLR4/NF-kappa B pathway.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Article
Environmental Sciences
Ping Zhang, Yandi Li, Wenping Xu, Jiagao Cheng, Cheng Zhang, Jufang Gao, Zhong Li, Liming Tao, Yang Zhang
Summary: Ivermectin is widely used as a biopesticide in animal husbandry and agriculture, but its immunotoxicity has received little attention. Research shows that Ivermectin can induce immunotoxicity through the induction of cytotoxicity and immune dysfunction.
Article
Environmental Sciences
Tingxu Yan, Xiaozhuo Zhang, Qianqian Mao, Bo Wu, Bosai He, Ying Jia, Lei Shang
Summary: Alpinae Oxyphyllae Fructus (AOF) has been shown to improve memory decline in LPS-induced AD mice by protecting neurons through the PI3K/AKT signaling pathway and reducing neuroinflammation levels. Additionally, AOF can decrease cytokine expression and NF-kappa B activity induced by LPS, demonstrating its potential anti-neuroinflammatory effects in AD models.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Plant Sciences
Jing Han, Haotian Zhang, Yu Zhang, Zan Zhang, Maomao Yu, Sijie Wang, Fei Han
Summary: This study evaluated the neuroprotective effects of Lingguizhugan decoction (LGZGD) on Aβ25-35-induced PC12 cells and elucidated its molecular mechanism. The results showed that LGZGD increased cell viability, reduced inflammatory factors, inhibited cell apoptosis, and modulated the NF-κB/MAPK signaling pathways. Therefore, LGZGD may be a valuable drug candidate for attenuating Aβ25-35-induced neurotoxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fengmao An, Xinran Xuan, Zheng Liu, Ming Bian, Qingkun Shen, Zheshan Quan, Guowei Zhang, Chengxi Wei
Summary: In this study, the potential of a compound called W112 for the treatment of Alzheimer's disease (AD) was investigated. The results showed that W112 has neuroprotective effects against AD-like pathology, improving learning and memory abilities in AD-induced rats and reversing tau hyperphosphorylation. It also reduced the production of proinflammatory cytokines in vitro and in vivo.
Editorial Material
Microbiology
Robert Z. Zhang, Melissa Kane
Summary: HIV-1 both inhibits and activates the NF-kappa B pathway, which is important for the viral life cycle. The viral protein U has contrasting effects on beta-TrCP1 and beta-TrCP2, leading to dysregulation of the NF-kappa B pathways. These findings enhance our understanding of how the NF-kappa B pathway functions during viral infection.
Article
Food Science & Technology
Reham I. Alagal, Nora A. AlFaris, Ghedeir M. Alshammari, Jozaa Z. ALTamimi, Lujain A. AlMousa, Mohammed Abdo Yahya
Summary: This study demonstrates that kaempferol protects the structure and function of the kidneys in doxorubicin-treated rats by upregulating and activating SIRT1, thereby alleviating doxorubicin-induced nephropathy.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Environmental Sciences
Khalaf F. F. Alsharif, Ashraf Albrakati, Naif E. E. Al Omairi, Abdulraheem S. S. Almalki, Walaa Alsanie, Zakaria Y. Y. Abd Elmageed, Fahad Alharthi, Hussam A. A. Althagafi, Abdullah A. A. Alghamdi, Ibrahim Eid Hassan, Ola A. A. Habotta, Maha S. S. Lokman, Rami B. B. Kassab, Rehab E. E. El-Hennamy
Summary: This study investigated the neuroprotective potential of Prodigiosin against aluminum chloride-induced neurological damage. The results showed that Prodigiosin exhibited neuroregulatory, antioxidative, anti-inflammatory, and anti-apoptotic activities, making it a promising therapeutic option for Alzheimer's disease.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Immunology
Xiaoyue Guan, Yani He, Zhichen Wei, Chen Shi, Yingxue Li, Rui Zhao, Lifei Pan, Yue Han, Tiezhou Hou, Jianmin Yang
Summary: The crosstalk between Wnt3a/beta-catenin and NF-kappa B signaling pathways plays a crucial role in the development of apical periodontitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Shanshan Chen, Honghan Liu, Shimiao Wang, Hongbo Jiang, Le Gao, Lu Wang, Lesheng Teng, Chunyue Wang, Di Wang
Summary: The neuroprotective mechanism of Verbascoside (VB) was explored in this study. Proteomic analysis and immunological methods revealed that VB exerts its neuroprotective effect by inhibiting neuroinflammation and modulating the NF-kappa B-p65 pathway. These findings suggest that VB could be a potential candidate drug for the prevention and treatment of Alzheimer's disease (AD).
Article
Immunology
Lin Wei, Xiaowen Yang, Jie Wang, Zhixiao Wang, Qiguang Wang, Yan Ding, Aiqing Yu
Summary: Cellular senescence is a fundamental activity driving the aging process and is closely associated with age-related diseases, including Alzheimer's disease (AD). In this study, the elevated levels of lactic acid in senescent microglia and hippocampus tissues of naturally aged mice and AD mice models were quantified. The study also identified the role of H3K18la/NF?B axis in modulating the production of IL-6 and IL-8, which are components of the senescence-associated secretory phenotype (SASP).
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Rajendra Sangaraju, Sateesh Alavala, Nasiruddin Nalban, Mahesh Kumar Jerald, Ramakrishna Sistla
Summary: The study demonstrated that galangin (GAL) has a significant protective effect on skin inflammation induced by psoriasis-like symptoms, possibly through modulation of inflammatory pathways and oxidative stress. Galangin also regulated protein levels and antioxidant markers, showing potential for treating psoriasis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Sheetal Kashyap, Soumya Pal, Gourav Chandan, Vipin Saini, Sasanka Chakrabarti, Neeraj K. Saini, Amit Mittal, Vijay Kumar Thakur, Adesh K. Saini, Reena V. Saini
Summary: The interaction between gut microbes and GI tract carcinogenesis plays a role in the occurrence and development of GI cancers. Understanding the roles of microbes and their metabolites can help identify potential diagnostic and prognostic markers for cancer. However, the diagnostic efficiency of microbial markers needs further validation due to variations in microbiota profiles among individuals and populations.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Clinical Neurology
Ashwani Bhat, Atanu Biswas, Gautam Das, Durjoy Lahiri, Souvik Dubey, Adreesh Mukherjee
Summary: Dementia of vascular origin is a heterogeneous disease with distinct neuropsychological profiles. This study compares behavioral dysfunction in large vessel and small vessel vascular dementia (VaD) and explores the association between executive dysfunction and behavioral dysfunction in these patients, as well as the relationship between white matter load in small vessel disease (SVD) and behavioral dysfunction.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Pharmacology & Pharmacy
Ashutosh Tiwari, Gaurav Karna, Sankha Shubhra Chakrabarti, Prasan Kumar Panda, Upinder Kaur
Summary: A young man presented with periorbital swelling, finger swelling, tachycardia, and breathlessness after receiving the COVAXIN vaccine. He was found to have elevated blood eosinophils and myocarditis. Treatment with steroids and supportive care resulted in successful recovery. This is the first reported case of hyper-eosinophilia syndrome after COVAXIN administration, and vigilance is necessary for such adverse events.
CURRENT DRUG SAFETY
(2023)
Article
Public, Environmental & Occupational Health
Upinder Kaur, K. L. Anju, Mayank Chauhan, Aditi Joshi, Agniva Das, Sangeeta Kansal, Vaibhav Jaisawal, Kishor Patwardhan, Sankha Shubhra Chakrabarti
Summary: The study provides real-world safety data of COVAXIN vaccine in adolescents, showing a favorable safety profile in the short term, with most adverse events being mild to moderate. There were no significant differences in adverse event incidence between adolescents and adults.
Article
Audiology & Speech-Language Pathology
Madhushree Chakrabarty, Kaberi Bhattacharya, Garga Chatterjee, Atanu Biswas, Malay Ghosal
Summary: This study compares the pragmatic deficits of patients with schizophrenia and right hemisphere damage. The findings show that both patient groups have significant pragmatic deficits. When controlled for age and education, schizophrenia patients score significantly better in six out of ten pragmatic skills compared to the right hemisphere damage group. The study suggests that there is heterogeneity in the nature of pragmatic breakdown within and across patient groups, and individualized restorative measures may help improve pragmatic competence.
INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS
(2023)
Editorial Material
Pharmacology & Pharmacy
Upinder Kaur, Sankha Shubhra Chakrabarti
CURRENT DRUG SAFETY
(2023)
Article
Pharmacology & Pharmacy
Sumit Jaiswal, Sankha Shubhra Chakrabarti, Tulika Rai, Neeraj Dhameja, Atul Mohan, Vandana Yadav, Upinder Kaur
Summary: Pregabalin, commonly used in the treatment of neuropathic pain and epilepsy, can cause skin rashes. This case report describes a maculopapular rash induced by pregabalin in an older man, which resolved after withdrawal of the drug and conservative management. The article also provides a review of similar cases and management strategies for pregabalin-induced skin rashes.
CURRENT DRUG SAFETY
(2022)
Review
Clinical Neurology
Amlan Datta, Adreesh Mukherjee, Atanu Biswas
Summary: Since the emergence of COVID-19, there is evidence to suggest that SARS-Cov2 can disrupt cellular pathways and raise concerns about long-term effects on survivors, particularly in relation to neurodegenerative diseases like PD. The interaction between environmental factors and alpha-synuclein formation, as well as the infiltration of SARS-CoV2 in the olfactory bulb and vagal autonomic terminals, may lead to the spread of viral particles to the brain through multiple cranial nerve routes. The ability of SARS-Cov2 to induce abnormal protein folding and stress responses in the central nervous system, combined with inflammation, hypoxia, coagulopathy, and endothelial dysfunction, raises the intriguing possibility of triggering a neurodegenerative cascade in PD development.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2023)
Article
Pediatrics
Suman Das, Atanu Biswas, Uma Sinha Roy, Biman Kanti Ray
Summary: A 6-year-old thalassemic boy developed a sudden thunderclap headache after blood transfusion. Imaging showed bleeding in the left occipital lobe and diffuse cerebral vasoconstriction, which resolved after 3 months. Treatment with nimodipine for 3 months resulted in full recovery without any complications. This is the first reported case of reversible cerebral vasoconstriction syndrome in a thalassemic child.
JOURNAL OF PEDIATRIC NEUROLOGY
(2023)
Article
Clinical Neurology
Dipanwita Sadhukhan, Aishwarya Mallick, Smriti Mishra, Adreesh Mukherjee, Atanu Biswas, Subhra P. Hui, Arindam Biswas
Summary: This study presents a case of an Indian female patient with clinical symptoms of both Alzheimer's disease and parkinsonism, including rapid dystonia progression. Whole-exome sequencing revealed a heterozygous mutation in the ATP-binding cassette transporter A7 gene and double heterozygous mutation in PRKN. The findings highlight the complex etiology of neurodegenerative disorders and emphasize the importance of genetic tests, such as whole-exome sequencing, in complex diseases.
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Upinder Kaur, Zeba Fatima, Kalika Maheshwari, Vikas Sahni, Amol Dehade, K. L. Anju, Ashish Kumar Yadav, Sangeeta Kansal, Vaibhav Jaisawal, Sankha Shubhra Chakrabarti
Summary: This study aimed to provide one-year safety results of the ChAdOx1-nCoV-19/AZD1222 vaccine and determine the risk factors and persistence of adverse events. The results showed that 44.1% of vaccine recipients developed COVID-19 and 8% developed dengue. Regression analysis indicated that females, individuals with a pre-vaccination history of COVID-19, diabetes, hypothyroidism, and arthropathy had a higher risk of adverse events. Vaccination after natural infection increased the risk of persistent adverse events. Future research should explore sex and endocrine differences and timing of vaccination as determinants of adverse events and investigate the pathogenetic mechanisms and overall safety profile of COVID-19 vaccines.
Editorial Material
Clinical Neurology
Arka Prava Chakraborty, Adreesh Mukherjee, Atanu Biswas
Summary: This case report discusses a patient with multiple medical conditions, including diabetes, hypertension, and a history of cerebral hemorrhage and hemiparesis. The patient developed noncontiguous overflow dystonia.
Review
Clinical Neurology
Amlan Datta, Adreesh Mukherjee, Atanu Biswas
Summary: Since the emergence of COVID-19, evidence has shown that SARS-Cov2 affects not only the lungs but also various cellular pathways related to protein homeostasis, mitochondrial function, stress response, and aging. Survivors of COVID-19 may be at risk for developing neurodegenerative diseases, including Parkinson's disease, due to the virus's ability to invade the central nervous system and induce abnormal protein folding and stress response. However, more robust evidence is needed to confirm this potential link.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2023)
Article
Clinical Neurology
Sourav Banerjee, Adreesh Mukherjee, Bidisha Bhattacharyya, Kochupurackal P. Mohanakumar, Atanu Biswas
Summary: This study evaluated the quality of life and concerns of Parkinson's disease patients and their caregivers during the COVID-19 pandemic. The results showed that the QoL of both patients and caregivers worsened during the second wave of the pandemic. Many individuals reported anxiety and depression, with concerns primarily focused on social isolation, activity restrictions, and financial issues.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2022)
Article
Clinical Neurology
Subhadeep Gupta, Atanu Biswas, Atanu Chandra, Biman Kanti Ray, Arpan Dutta, Alak Pandit
Summary: This study analyzed the detailed clinical presentations and outcomes of 17 cases with neurological complications following acute varicella infection. Peripheral nervous system involvement was more common compared to central nervous system involvement. Varicella encephalitis and ataxia were not common in this study group, but treatment response was generally good.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2022)
