Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans

Recent Progress in Alzheimer’s Disease Research, Part 2: Genetics and Epidemiology

(2017) Morgan Robinson et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia

(2017) Grietje Krabbe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF-κB Immunity in the Brain Determines Fly Lifespan in Healthy Aging and Age-Related Neurodegeneration

(2017) Ilias Kounatidis et al.   Cell Reports

Why has therapy development for dementia failed in the last two decades?

(2016) Serge Gauthier et al.   Alzheimers & Dementia

NOVEL TRANSCRIPTIONAL ROLE OF APOE4

(2016) Veena P. Theendakara et al.   Alzheimers & Dementia

Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression

(2016) Brian Hallahan et al.   BRITISH JOURNAL OF PSYCHIATRY

Alcohol resistance inDrosophilais modulated by the Toll innate immune pathway

(2016) B. R. Troutwine et al.   GENES BRAIN AND BEHAVIOR

Regulation of cyclic AMP response element-binding protein during neuroglial interactions

(2016) LiMei Qin et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of SET Gene Expression by NFkB

(2016) Yi Feng et al.   MOLECULAR NEUROBIOLOGY

Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats

(2016) Shafiq Ur Rehman et al.   MOLECULAR NEUROBIOLOGY

The Curcumin Analog C-150, Influencing NF-κB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo

(2016) László Hackler et al.   PLoS One

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals

(2016) José D. Botezelli et al.   Scientific Reports

Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44 and S100a4 as Treatment Targets

(2016) Anssi Lipponen et al.   Scientific Reports

Using Drosophila as an integrated model to study mild repetitive traumatic brain injury

(2016) Ayeh Barekat et al.   Scientific Reports

Promise of new Alzheimer’s drug is dashed after lack of evidence

(2016) Nigel Hawkes   BMJ-British Medical Journal

Promise of new Alzheimer’s drug is dashed after lack of evidence

(2016) Nigel Hawkes   BMJ-British Medical Journal

Deletion of nuclear factor-κB p50 upregulates fatty acid utilization and contributes to an anti-obesity and high-endurance phenotype in mice

(2015) Yoshihiko Minegishi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Alzheimer-associated A  oligomers impact the central nervous system to induce peripheral metabolic deregulation

(2015) J. R. Clarke et al.   EMBO Molecular Medicine

All-trans-retinoic Acid ReducesBACE1Expression under Inflammatory Conditions via Modulation of Nuclear Factor κB (NFκB) Signaling

(2015) Ruishan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The protein arginine methyltransferase PRMT5 regulates Aβ-induced toxicity in human cells andCaenorhabditis elegansmodels of Alzheimer's disease

(2015) Xin Quan et al.   JOURNAL OF NEUROCHEMISTRY

Lactobacillus pentosusvar.plantarumC29 ameliorates age-dependent memory impairment in Fischer 344 rats

(2015) J.-J. Jeong et al.   LETTERS IN APPLIED MICROBIOLOGY

Age-Dependent Alterations in the Interactions of NF-κB and N-myc with GLT-1/EAAT2 Promoter in the Pericontusional Cortex of Mice Subjected to Traumatic Brain Injury

(2015) Rajaneesh K. Gupta et al.   MOLECULAR NEUROBIOLOGY

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation

(2015) Bryce A Mander et al.   NATURE NEUROSCIENCE

Metabolic learning and memory formation by the brain influence systemic metabolic homeostasis

(2015) Yumin Zhang et al.   Nature Communications

Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease

(2015) Xinzhong Li et al.   Scientific Reports

Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction

(2015) Rebeccah J Katzenberger et al.   eLife

Mindfulness Meditation and Improvement in Sleep Quality and Daytime Impairment Among Older Adults With Sleep Disturbances

(2015) David S. Black et al.   JAMA Internal Medicine

Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

(2015) Xiaohua Li et al.   Clinical Interventions in Aging

Plant polyphenols as inhibitors of NF-κB induced cytokine production—a potential anti-inflammatory treatment for Alzheimer's disease?

(2015) Niloo Karunaweera et al.   Frontiers in Molecular Neuroscience

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Cellular Defense and Sensory Cell Survival Require Distinct Functions of ebi in Drosophila

(2015) Young-Mi Lim et al.   PLoS One

Future directions in Alzheimer's disease from risk factors to prevention

(2014) Bushra Imtiaz et al.   BIOCHEMICAL PHARMACOLOGY

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

Activation of NF-κB Mediates Astrocyte Swelling and Brain Edema in Traumatic Brain Injury

(2014) Arumugam R. Jayakumar et al.   JOURNAL OF NEUROTRAUMA

CR1 in Alzheimer's Disease

(2014) Xi-Chen Zhu et al.   MOLECULAR NEUROBIOLOGY

Protection of the Developing Brain with Anthocyanins Against Ethanol-Induced Oxidative Stress and Neurodegeneration

(2014) Shahid Ali Shah et al.   MOLECULAR NEUROBIOLOGY

Increases in β-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-κB pathway activation

(2014) Zhiyou Cai et al.   Pharmacological Reports

The Proinflammatory RAGE/NF-κB Pathway Is Involved in Neuronal Damage and Reactive Gliosis in a Model of Sleep Apnea by Intermittent Hypoxia

(2014) Maria Florencia Angelo et al.   PLoS One

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications

(2014) Jun Wang et al.   Frontiers in Aging Neuroscience

Drosophila as a model to study the role of blood cells in inflammation, innate immunity and cancer

(2014) Lihui Wang et al.   Frontiers in Cellular and Infection Microbiology

The worldwide economic impact of dementia 2010

(2013) Anders Wimo et al.   Alzheimers & Dementia

Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner

(2013) Eric K. Long et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Treadmill exercise induces age-related changes in aversive memory, neuroinflammatory and epigenetic processes in the rat hippocampus

(2013) Gisele Agustini Lovatel et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Leukotriene D4 induces amyloid-β generation via CysLT1R-mediated NF-κB pathways in primary neurons

(2013) Xiao Yun Wang et al.   NEUROCHEMISTRY INTERNATIONAL

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Regulation of TREM2 expression by an NF-кB-sensitive miRNA-34a

(2013) Yuhai Zhao et al.   NEUROREPORT

A Pro-Inflammatory Role for Nuclear Factor Kappa B in Childhood Obstructive Sleep Apnea Syndrome

(2013) Lee P. Israel et al.   SLEEP

Drosophila innate immune response pathways moonlight in neurodegeneration

(2012) Andrew J. Petersen et al.   FLY

Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-γ systems

(2012) P W Gold et al.   MOLECULAR PSYCHIATRY

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Adiponectin is Protective against Oxidative Stress Induced Cytotoxicity in Amyloid-Beta Neurotoxicity

(2012) Koon-Ho Chan et al.   PLoS One

Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines

(2012) R. Narasimamurthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila as a model system to unravel the layers of innate immunity to infection

(2012) I. Kounatidis et al.   Open Biology

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Tyrosol and Hydroxytyrosol Two Main Components of Olive Oil, Protect N2a Cells Against Amyloid-β-Induced Toxicity. Involvement of the NF-κB Signaling

(2011) C. St-Laurent-Thibault et al.   Current Alzheimer Research

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

(2011) Chia-Hsiung Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade

(2011) Hemachander Capiralla et al.   JOURNAL OF NEUROCHEMISTRY

Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB

(2011) Sudarshana Purkayastha et al.   NATURE MEDICINE

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

Apolipoprotein E isoform-specific effects on cytokine and nitric oxide production from mouse Schwann cells after inflammatory stimulation

(2011) Ke-Jia Zhang et al.   NEUROSCIENCE LETTERS

Induction of Innate Immune Gene Expression Cascades in Brain Slice Cultures by Ethanol: Key Role of NF-κB and Proinflammatory Cytokines

(2010) Jian Zou et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Modulation of age-related NF-κB activation by dietary zingerone via MAPK pathway

(2010) Mi Kyung Kim et al.   EXPERIMENTAL GERONTOLOGY

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

(2010) Michela Guglielmotto et al.   NEUROBIOLOGY OF AGING

Alzheimer's Disease and tauopathy studies in flies and worms

(2010) Jill Wentzell et al.   NEUROBIOLOGY OF DISEASE

Expression of the apoptosis-related proteins caspase-3 and NF-κB in the hippocampus of Tg2576 mice

(2010) Yan-Li Niu et al.   Neuroscience Bulletin

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

(2010) Eduardo R. Ropelle et al.   PLOS BIOLOGY

When Sirtuins and NF-κB Collide

(2009) Gioacchino Natoli   CELL

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Apolipoprotein E-Mimetics Inhibit Neurodegeneration and Restore Cognitive Functions in a Transgenic Drosophila Model of Alzheimer's Disease

(2009) Svetlana Sarantseva et al.   PLoS One

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

The Toll→NFκB Signaling Pathway Mediates the Neuropathological Effects of the Human Alzheimer's Aβ42 Polypeptide in Drosophila

(2008) Lihua Tan et al.   PLoS One