Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting

The role of miR-200b/c in balancing EMT and proliferation revealed by an activity reporter

(2021) Paradesi Naidu Gollavilli et al.   ONCOGENE

PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics

(2020) Sajid Khan et al.   ONCOGENE

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin

(2020) Yacob Gomez-Llorente et al.   Nature Communications

Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors?

(2020) Alberto Fucarino et al.   Journal of Oncology

Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer

(2020) Mohammad Aarif Siddiqui et al.   BRITISH JOURNAL OF CANCER

Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers

(2019) Aarif Siddiqui et al.   CELL DEATH AND DIFFERENTIATION

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

(2019) Fiona M. Behan et al.   NATURE

The landscape of cancer cell line metabolism

(2019) Haoxin Li et al.   NATURE MEDICINE

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer

(2019) Nan Jin et al.   Nature Communications

Targeting the Complement Pathway as a Therapeutic Strategy in Lung Cancer

(2019) Emily K. Kleczko et al.   Frontiers in Immunology

HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells

(2019) Ruifang Teng et al.   Redox Biology

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

(2019) Jiyeon Kim et al.   Cell Metabolism

Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

(2019) Liangliang Ji et al.   IMMUNITY

Non–Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment

(2019) Narjust Duma et al.   MAYO CLINIC PROCEEDINGS

Heat-shock proteins: chaperoning DNA repair

(2019) Laurence Dubrez et al.   ONCOGENE

Chemotherapy remains a cornerstone in the treatment of nonsmall cell lung cancer

(2019) Robert Pirker   CURRENT OPINION IN ONCOLOGY

Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy

(2019) Zuan-Fu Lim et al.   Journal of Hematology & Oncology

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

(2019) Alba Luengo et al.   Nature Communications

Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy

(2019) Chul Won Yun et al.   Cells

Metabolic vulnerability of cisplatin‐resistant cancers

(2018) Florine Obrist et al.   EMBO JOURNAL

Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth

(2018) Chao Zhou et al.   Cell Death & Disease

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice

(2018) Euan S. Polson et al.   Science Translational Medicine

Heat Shock Proteins as Immunomodulants

(2018) Tawanda Zininga et al.   MOLECULES

Hsp60 in Skeletal Muscle Fiber Biogenesis and Homeostasis: From Physical Exercise to Skeletal Muscle Pathology

(2018) Antonella Marino Gammazza et al.   Cells

Targeting metabolic reprogramming in KRAS-driven cancers

(2017) Kenji Kawada et al.   International Journal of Clinical Oncology

The between Now and Then of Lung Cancer Chemotherapy and Immunotherapy

(2017) Roberta Visconti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial-to-mesenchymal transition of cancer cells

(2017) Aarif Siddiqui et al.   JOURNAL OF PATHOLOGY

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

(2017) Nina Fenouille et al.   NATURE MEDICINE

The heat-shock protein/chaperone network and multiple stress resistance

(2017) Pierre Jacob et al.   PLANT BIOTECHNOLOGY JOURNAL

Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy

(2017) Lais Osmani et al.   SEMINARS IN CANCER BIOLOGY

Heat Shock Proteins and Cancer

(2017) Jianming Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mitochondrial markers predict survival and progression in non-small cell lung cancer (NSCLC) patients: Use as companion diagnostics

(2017) Federica Sotgia et al.   Oncotarget

NLRC5 Functions beyond MHC I Regulation—What Do We Know So Far?

(2017) Szilvia Benkő et al.   Frontiers in Immunology

Clinical, Prognostic and Therapeutic Significance of Heat Shock Proteins in Cancer

(2017) Jasleen Saini et al.   CURRENT DRUG TARGETS

PROCLAIM: Randomized Phase III Trial of Pemetrexed-Cisplatin or Etoposide-Cisplatin Plus Thoracic Radiation Therapy Followed by Consolidation Chemotherapy in Locally Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2016) Suresh Senan et al.   JOURNAL OF CLINICAL ONCOLOGY

Mitochondrial function controls intestinal epithelial stemness and proliferation

(2016) Emanuel Berger et al.   Nature Communications

Heat shock proteins in multiple myeloma

(2015) Lei Zhang et al.   Oncotarget

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Heat shock protein-60 expression was significantly correlated with the prognosis of lung adenocarcinoma

(2011) Xin Xu et al.   JOURNAL OF SURGICAL ONCOLOGY

Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis

(2010) Yaw Chong Goh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A small molecule accelerates neuronal differentiation in the adult rat

(2010) H. Wurdak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction between HSP60 and β-catenin promotes metastasis

(2009) Ya-Ping Tsai et al.   CARCINOGENESIS

Updated Clinical Information on Multitargeted Antifolates in Lung Cancer

(2009) Giorgio V. Scagliotti et al.   Clinical Lung Cancer