标题
Targeting metabolic reprogramming in KRAS-driven cancers
作者
关键词
KRAS, Cancer metabolism, Reprograming, Glycolysis, Glutaminolysis
出版物
International Journal of Clinical Oncology
Volume 22, Issue 4, Pages 651-659
出版商
Springer Nature
发表日期
2017-06-24
DOI
10.1007/s10147-017-1156-4
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma
- (2017) Arvin M. Gouw et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glutamine transporters in mammalian cells and their functions in physiology and cancer
- (2016) Yangzom D. Bhutia et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
- (2016) Shawn M. Davidson et al. Cell Metabolism
- Relationship Between 18F-Fluorodeoxyglucose Uptake and V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog Mutation in Colorectal Cancer Patients
- (2016) Jae-Hoon Lee et al. MEDICINE
- Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer
- (2016) Yi-Ping Wang et al. MOLECULAR CELL
- A combinatorial strategy for treating KRAS-mutant lung cancer
- (2016) Eusebio Manchado et al. NATURE
- Metabolic rewiring in melanoma
- (2016) B I Ratnikov et al. ONCOGENE
- Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
- (2016) J. R. Mayers et al. SCIENCE
- The role of wild type RAS isoforms in cancer
- (2016) Bingying Zhou et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
- (2016) Abigail S. Krall et al. Nature Communications
- Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer
- (2016) Oscar Aguilera et al. Oncotarget
- Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer
- (2016) Masaaki Miyo et al. Scientific Reports
- Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis
- (2016) Mahesh S. Padanad et al. Cell Reports
- Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase
- (2016) Kosuke Toda et al. NEOPLASIA
- Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs
- (2015) Y. D. Bhutia et al. CANCER RESEARCH
- The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1
- (2015) Wilhelm Palm et al. CELL
- Metabolic Dependencies in RAS-Driven Cancers
- (2015) A. C. Kimmelman CLINICAL CANCER RESEARCH
- Relationship Between 18F-FDG PET/CT Scans and KRAS Mutations in Metastatic Colorectal Cancer
- (2015) K. Kawada et al. JOURNAL OF NUCLEAR MEDICINE
- SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
- (2015) Dohoon Kim et al. NATURE
- The consensus molecular subtypes of colorectal cancer
- (2015) Justin Guinney et al. NATURE MEDICINE
- Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy
- (2015) Christina H. Eng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
- (2015) J. Yun et al. SCIENCE
- Targeting cancer cell metabolism in pancreatic adenocarcinoma
- (2015) Romain Cohen et al. Oncotarget
- Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma
- (2015) Simone Hettmer et al. eLife
- Combined autophagy and HDAC inhibition
- (2014) Devalingam Mahalingam et al. Autophagy
- A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme
- (2014) Myrna R Rosenfeld et al. Autophagy
- Correlation Between PET/CT Parameters and KRAS Expression in Colorectal Cancer
- (2014) Shang-Wen Chen et al. CLINICAL NUCLEAR MEDICINE
- The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation
- (2014) Alfredo Csibi et al. CURRENT BIOLOGY
- Role of [18F]FDG PET in prediction of KRAS and EGFR mutation status in patients with advanced non-small-cell lung cancer
- (2014) Carlos Caicedo et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Regulation of 18F-FDG Accumulation in Colorectal Cancer Cells with Mutated KRAS
- (2014) M. Iwamoto et al. JOURNAL OF NUCLEAR MEDICINE
- Multifunctional Imaging Signature for V-KI-RAS2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutations in Colorectal Cancer
- (2014) K. A. Miles et al. JOURNAL OF NUCLEAR MEDICINE
- Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion
- (2014) Ji Zhang et al. MOLECULAR CELL
- Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
- (2014) Jared R Mayers et al. NATURE MEDICINE
- Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma
- (2014) B. M. Wolpin et al. ONCOLOGIST
- KRAS: feeding pancreatic cancer proliferation
- (2014) Kirsten L. Bryant et al. TRENDS IN BIOCHEMICAL SCIENCES
- Asparagine synthetase: regulation by cell stress and involvement in tumor biology
- (2013) Mukundh N. Balasubramanian et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer
- (2013) Krushna C. Patra et al. CANCER CELL
- Exploiting the bad eating habits of Ras-driven cancers
- (2013) E. White GENES & DEVELOPMENT
- Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
- (2013) J. Y. Guo et al. GENES & DEVELOPMENT
- Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
- (2013) Cosimo Commisso et al. NATURE
- Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
- (2013) Jaekyoung Son et al. NATURE
- Metabolic targets for cancer therapy
- (2013) Lorenzo Galluzzi et al. NATURE REVIEWS DRUG DISCOVERY
- Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
- (2013) J. J. Kamphorst et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells
- (2012) Hideyuki Ikeuchi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
- (2012) Haoqiang Ying et al. CELL
- Relationship between 18F-Fluorodeoxyglucose Accumulation and KRAS/BRAF Mutations in Colorectal Cancer
- (2012) K. Kawada et al. CLINICAL CANCER RESEARCH
- Pancreatic Tumor Sensitivity to Plasma L-Asparagine Starvation
- (2012) Emmanuelle Dufour et al. PANCREAS
- Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
- (2012) M. Jain et al. SCIENCE
- Pancreatic cancers require autophagy for tumor growth
- (2011) S. Yang et al. GENES & DEVELOPMENT
- Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
- (2011) J. Y. Guo et al. GENES & DEVELOPMENT
- Pancreatic cancer
- (2011) Audrey Vincent et al. LANCET
- The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
- (2010) Jiangbin Ye et al. EMBO JOURNAL
- Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
- (2010) F. Weinberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy and Metabolism
- (2010) J. D. Rabinowitz et al. SCIENCE
- Glutamine addiction: a new therapeutic target in cancer
- (2010) David R. Wise et al. TRENDS IN BIOCHEMICAL SCIENCES
- 18F-FDG Uptake in Lung, Breast, and Colon Cancers: Molecular Biology Correlates and Disease Characterization
- (2009) H. Jadvar et al. JOURNAL OF NUCLEAR MEDICINE
- Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
- (2009) R J DeBerardinis et al. ONCOGENE
- Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
- (2009) J. Yun et al. SCIENCE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- KRASMutations As an Independent Prognostic Factor in Patients With Advanced Colorectal Cancer Treated With Cetuximab
- (2008) Astrid Lièvre et al. JOURNAL OF CLINICAL ONCOLOGY
- Ras oncogenes: split personalities
- (2008) Antoine E. Karnoub et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Lung Cancer
- (2008) Roy S. Herbst et al. NEW ENGLAND JOURNAL OF MEDICINE
- K-rasMutations and Benefit from Cetuximab in Advanced Colorectal Cancer
- (2008) Christos S. Karapetis et al. NEW ENGLAND JOURNAL OF MEDICINE
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