标题
The long journey to bring a Myc inhibitor to the clinic
作者
关键词
-
出版物
JOURNAL OF CELL BIOLOGY
Volume 220, Issue 8, Pages -
出版商
Rockefeller University Press
发表日期
2021-06-23
DOI
10.1083/jcb.202103090
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- MYC as a Target for Cancer Treatment
- (2021) Michael J Duffy et al. CANCER TREATMENT REVIEWS
- Capitalizing on Synthetic Lethality of MYC to Treat Cancer in the Digital Age
- (2021) Dexter Kai Hao Thng et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers
- (2021) Adam J. Wolpaw et al. CANCER RESEARCH
- A bacterial protease depletes c-MYC and increases survival in mouse models of bladder and colon cancer
- (2021) Daniel S. C. Butler et al. NATURE BIOTECHNOLOGY
- G-quadruplex binding properties of a potent PARP-1 inhibitor derived from 7-azaindole-1-carboxamide
- (2021) Sabrina Dallavalle et al. Scientific Reports
- Targeting MYCN in Pediatric and Adult Cancers
- (2021) Zhihui Liu et al. Frontiers in Oncology
- Targeting MYCN in Molecularly Defined Malignant Brain Tumors
- (2021) Anna Borgenvik et al. Frontiers in Oncology
- Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders
- (2021) Anja Dölle et al. JOURNAL OF MEDICINAL CHEMISTRY
- MYC, MYCL, and MYCN as therapeutic targets in lung cancer
- (2020) Daniel Massó-Vallés et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Inhibition of Myc Transcriptional Activity by a Mini Protein Based Upon Mxd1
- (2020) Mark J. Demma et al. FEBS LETTERS
- Discovery of WD Repeat-Containing Protein 5 (WDR5)–MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design
- (2020) Selena Chacón Simon et al. JOURNAL OF MEDICINAL CHEMISTRY
- Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc
- (2020) Daniel Massó-Vallés et al. Cells
- Structural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein
- (2020) Marie-Eve Beaulieu et al. Cells
- Syntheses and Evaluation of New Bisacridine Derivatives for Dual Binding of G-Quadruplex and i-Motif in Regulating Oncogene c-myc Expression
- (2020) Guo-Tao Kuang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nanoformulation of PROteolysis TArgeting Chimera targeting ‘undruggable’ c-Myc for the treatment of pancreatic cancer
- (2020) Aishwarya Saraswat et al. Nanomedicine
- The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma
- (2020) Lisa J. Crawford et al. ONCOGENE
- MYC Antisense Oligonucleotide Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse models of Hepatocellular and Renal Cell Carcinoma
- (2020) Renumathy Dhanasekaran et al. Molecular Therapy-Nucleic Acids
- Turning up the heat on MYC: Progress in small molecule inhibitors
- (2020) Mihai I Truica et al. CANCER RESEARCH
- PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase
- (2020) Bikash Adhikari et al. Nature Chemical Biology
- Targeting c-Myc with a novel Peptide Nuclear Delivery Device
- (2020) Trinda Anne Ting et al. Scientific Reports
- Human MYC G-quadruplex: From discovery to a cancer therapeutic target
- (2020) Wenmeng Wang et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Curcumin analogs exhibit anti-cancer activity by selectively targeting G-quadruplex forming c-myc promoter sequence
- (2020) Nirali Pandya et al. BIOCHIMIE
- PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor Activity in Neuroblastoma by Repressing Expression of MYCN or c-Myc
- (2020) Zhiheng Li et al. Frontiers in Oncology
- Anti-c-myc RNAi-Based Onconanotherapeutics
- (2020) Saffiya Habib et al. Biomedicines
- A chemical approach for global protein knockdown from mice to non-human primates
- (2019) Xiuyun Sun et al. Cell Discovery
- Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy
- (2019) Marie-Eve Beaulieu et al. Science Translational Medicine
- Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy
- (2019) Sefan Asamitsu et al. MOLECULES
- A Phase 2 Study of Alisertib in Children with Recurrent/Refractory Solid Tumors or Leukemia: Children's Oncology Group Phase 1 and Pilot Consortium ADVL0921)
- (2019) Yael P. Mosse et al. CLINICAL CANCER RESEARCH
- Paclitaxel and Alisertib in Recurrent Ovarian Cancer—In Reply
- (2019) Gerald Falchook et al. JAMA Oncology
- Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas
- (2019) Xuan Zhang et al. LEUKEMIA
- Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-Coil Domain Truncations
- (2019) Zachary Z. Brown et al. JOURNAL OF ORGANIC CHEMISTRY
- Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance
- (2019) Lance R. Thomas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chronic Microangiopathy Due to DCR-MYC, a Myc-Targeted Short Interfering RNA
- (2019) Aaron J. Miller et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Formation of a structurally-stable conformation by the intrinsically disordered MYC:TRRAP complex
- (2019) Edmond J. Feris et al. PLoS One
- APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells
- (2018) Andrea Local et al. MOLECULAR CANCER THERAPEUTICS
- A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation
- (2018) Alina Castell et al. Scientific Reports
- Inhibition of MYC attenuates tumor cell self-renewal and promotes senescence in SMARCB1 deficient Group 2 Atypical Teratoid Rhabdoid Tumors to suppress tumor growth in vivo
- (2018) Irina Alimova et al. INTERNATIONAL JOURNAL OF CANCER
- Tumor penetrating peptides inhibiting MYC as a potent targeted therapeutic strategy for triple-negative breast cancers
- (2018) Edina Wang et al. ONCOGENE
- Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches
- (2018) Lavinia Carabet et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Alisertib in Combination With Weekly Paclitaxel in Patients With Advanced Breast Cancer or Recurrent Ovarian Cancer
- (2018) Gerald Falchook et al. JAMA Oncology
- Inhibiting MYC binding to the E-box DNA motif by ME47 decreases tumour xenograft growth
- (2017) L C Lustig et al. ONCOGENE
- Elongation vs stalling: place your BET
- (2017) Elisa Donato et al. Oncotarget
- BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members
- (2016) S. J. Hogg et al. MOLECULAR CANCER THERAPEUTICS
- PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression
- (2016) Dai Horiuchi et al. NATURE MEDICINE
- PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
- (2016) Kanak Raina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MYC regulates the antitumor immune response through CD47 and PD-L1
- (2016) S. C. Casey et al. SCIENCE
- Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation
- (2016) Francesco Paolo Fiorentino et al. Oncotarget
- Different promoter affinities account for specificity in MYC-dependent gene regulation
- (2016) Francesca Lorenzin et al. eLife
- Cdk2: a key regulator of the senescence control function of Myc
- (2016) Per Hydbring et al. Aging-US
- Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc
- (2016) Chen Yu et al. Scientific Reports
- Small-molecule inhibitors of the Myc oncoprotein
- (2015) Steven Fletcher et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer
- (2015) S. Jain et al. CANCER RESEARCH
- Small Molecule MYC Inhibitor Conjugated to Integrin-Targeted Nanoparticles Extends Survival in a Mouse Model of Disseminated Multiple Myeloma
- (2015) D. Soodgupta et al. MOLECULAR CANCER THERAPEUTICS
- Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer
- (2015) A. Wiegering et al. Cancer Discovery
- Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer
- (2015) Ho Kyung Seo et al. Oncotarget
- Discovery of Methyl 4′-Methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate, an Improved Small-Molecule Inhibitor of c-Myc-Max Dimerization
- (2014) Jay Chauhan et al. ChemMedChem
- Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
- (2014) S. Peter et al. EMBO Molecular Medicine
- CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma
- (2014) Chun-Hao Huang et al. GENES & DEVELOPMENT
- Therapeutic Effects of an Anti-Myc Drug on Mouse Pancreatic Cancer
- (2014) Dimitris Stellas et al. JNCI-Journal of the National Cancer Institute
- Targeting Inhibitors of the Tumor Suppressor PP2A for the Treatment of Pancreatic Cancer
- (2014) Amy S. Farrell et al. MOLECULAR CANCER RESEARCH
- Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer
- (2014) M. Janghorban et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibitor of MYC identified in a Krohnke pyridine library
- (2014) J. R. Hart et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis
- (2014) Daniela Annibali et al. Nature Communications
- An Overview of MYC and Its Interactome
- (2014) M. Conacci-Sorrell et al. Cold Spring Harbor Perspectives in Medicine
- Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
- (2013) Jakob Lovén et al. CELL
- Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice
- (2013) L. Soucek et al. GENES & DEVELOPMENT
- Intravesical Instillation of c-MYC Inhibitor KSI-3716 Suppresses Orthotopic Bladder Tumor Growth
- (2013) Kyung-Chae Jeong et al. JOURNAL OF UROLOGY
- Thermally Targeted Delivery of a c-Myc Inhibitory Polypeptide Inhibits Tumor Progression and Extends Survival in a Rat Glioma Model
- (2013) Gene L. Bidwell et al. PLoS One
- A thermally targeted c-Myc inhibitory polypeptide inhibits breast tumor growth
- (2012) Gene L. Bidwell et al. CANCER LETTERS
- MYC on the Path to Cancer
- (2012) Chi V. Dang CELL
- Triggering Fbw7-Mediated Proteasomal Degradation of c-Myc by Oridonin Induces Cell Growth Inhibition and Apoptosis
- (2012) H.-L. Huang et al. MOLECULAR CANCER THERAPEUTICS
- BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
- (2011) Jake E. Delmore et al. CELL
- Tumor microenvironment: becoming sick of Myc
- (2011) Jonathan R. Whitfield et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Endogenous Myc maintains the tumor microenvironment
- (2011) N. M. Sodir et al. GENES & DEVELOPMENT
- Demonstration that Drug-targeted Down-regulation of MYC in Non-Hodgkins Lymphoma Is Directly Mediated through the Promoter G-quadruplex
- (2011) Robert V. Brown et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting MYC dependence in cancer by inhibiting BET bromodomains
- (2011) J. A. Mertz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis
- (2011) J. D. Kessler et al. SCIENCE
- Mechanisms of MYC stabilization in human malignancies
- (2010) Melissa R. Junttila et al. CELL CYCLE
- Making sense of G-quadruplex and i-motif functions in oncogene promoters
- (2010) Tracy A. Brooks et al. FEBS Journal
- Phase I Study of the Selective Aurora A Kinase Inhibitor MLN8054 in Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, and Pharmacodynamics
- (2010) T. Macarulla et al. MOLECULAR CANCER THERAPEUTICS
- Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma
- (2009) Tobias Otto et al. CANCER CELL
- Stabilizers of the Max Homodimer Identified in Virtual Ligand Screening Inhibit Myc Function
- (2009) H. Jiang et al. MOLECULAR PHARMACOLOGY
- Distinct Thresholds Govern Myc's Biological Output In Vivo
- (2008) Daniel J. Murphy et al. CANCER CELL
- Modelling Myc inhibition as a cancer therapy
- (2008) Laura Soucek et al. NATURE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now