期刊
MOLECULES
卷 24, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/molecules24030429
关键词
cancer therapy; telomere; oncogenes; G-quadruplex; selective ligands
资金
- JSPS
- NIH [1R01CA236350]
- Basic Science and Platform Technology Program for Innovative Biological Medicine by Japan Agency for Medical Research [18am0301005h0005]
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers. Therefore, ligands interacting with G4s have attracted great attention as potential anticancer therapies or in molecular probe applications. To date, a large variety of DNA/RNA G4 ligands have been developed by a number of laboratories. As protein-targeting drugs face similar situations, G-quadruplex-interacting drugs displayed low selectivity to the targeted G-quadruplex structure. This low selectivity could cause unexpected effects that are usually reasons to halt the drug development process. In this review, we address the recent research on synthetic G4 DNA-interacting ligands that allow targeting of selected G4s as an approach toward the discovery of highly effective anticancer drugs.
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