A chemical approach for global protein knockdown from mice to non-human primates

PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies

(2018) Yonghui Sun et al.   CELL RESEARCH

The dTAG system for immediate and target-specific protein degradation

(2018) Behnam Nabet et al.   Nature Chemical Biology

Editorial: Seeing is not always believing: lessons from knockout mice

(2017) Emilie Vénéreau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression

(2017) Bing Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identifying synthetic lethal targets using CRISPR/Cas9 system

(2017) Jaspreet Kaur Dhanjal et al.   METHODS

Genetic compensation: A phenomenon in search of mechanisms

(2017) Mohamed A. El-Brolosy et al.   PLoS Genetics

Catalytic in vivo protein knockdown by small-molecule PROTACs

(2015) Daniel P Bondeson et al.   Nature Chemical Biology

Phthalimide conjugation as a strategy for in vivo target protein degradation

(2015) G. E. Winter et al.   SCIENCE

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

(2014) Tang Hai et al.   CELL RESEARCH

Generation of targeted mouse mutants by embryo microinjection of TALENs

(2014) Benedikt Wefers et al.   METHODS

A highly effective TALEN-mediated approach for targeted gene disruption in Xenopus tropicalis and zebrafish

(2014) Yun Liu et al.   METHODS

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Evidence for Rapamycin Toxicity in Pancreatic β-Cells and a Review of the Underlying Molecular Mechanisms

(2013) Adam D. Barlow et al.   DIABETES

FK506 binding proteins: Cellular regulators of intracellular Ca2+ signalling

(2013) Debbi MacMillan   EUROPEAN JOURNAL OF PHARMACOLOGY

Progress and Prospects for Genetic Modification of Nonhuman Primate Models in Biomedical Research

(2013) A. W. S. Chan   ILAR JOURNAL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

FKBP12 Is a Critical Regulator of the Heart Rhythm and the Cardiac Voltage-Gated Sodium Current in Mice

(2011) Mitsunori Maruyama et al.   CIRCULATION RESEARCH

Review article Genetically modified animals for use in research and biotechnology

(2010) L.M. Chaible et al.   GENETICS AND MOLECULAR RESEARCH

Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation

(2008) Subeena Sood et al.   HEART RHYTHM