Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc

Binding cavities and druggability of intrinsically disordered proteins

(2015) Yugang Zhang et al.   PROTEIN SCIENCE

Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5

(2015) Huabo Wang et al.   Oncotarget

Discovery of Methyl 4′-Methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate, an Improved Small-Molecule Inhibitor of c-Myc-Max Dimerization

(2014) Jay Chauhan et al.   ChemMedChem

Systems Biology Brings New Dimensions for Structure-Based Drug Design

(2014) Jianfeng Pei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Therapeutic Effects of an Anti-Myc Drug on Mouse Pancreatic Cancer

(2014) Dimitris Stellas et al.   JNCI-Journal of the National Cancer Institute

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

(2014) Gergely Tóth et al.   PLoS One

Targeting of the MYCN Protein with Small Molecule c-MYC Inhibitors

(2014) Inga Müller et al.   PLoS One

Inhibitor of MYC identified in a Krohnke pyridine library

(2014) J. R. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advantages of proteins being disordered

(2014) Zhirong Liu et al.   PROTEIN SCIENCE

Binding Site Detection and Druggability Prediction of Protein Targets for Structure- Based Drug Design

(2013) Yaxia Yuan et al.   CURRENT PHARMACEUTICAL DESIGN

How to design a drug for the disordered proteins?

(2013) Calvin Yu-Chian Chen et al.   DRUG DISCOVERY TODAY

Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide

(2013) Maximillian Zhu et al.   JOURNAL OF CHEMICAL PHYSICS

Modulation of allostery by protein intrinsic disorder

(2013) Allan Chris M. Ferreon et al.   NATURE

Ligand Clouds around Protein Clouds: A Scenario of Ligand Binding with Intrinsically Disordered Proteins

(2013) Fan Jin et al.   PLoS Computational Biology

Mechanisms of small-molecule binding to intrinsically disordered proteins: Figure 1

(2012) Rémi Cuchillo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pharmacophore identification of c-Myc inhibitor 10074-G5

(2012) Jeremy L. Yap et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Intrinsically disordered proteins and novel strategies for drug discovery

(2012) Vladimir N. Uversky   Expert Opinion on Drug Discovery

Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry

(2012) Sophie R. Harvey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein disorder—a breakthrough invention of evolution?

(2011) Avner Schlessinger et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intrinsically disordered proteins from A to Z

(2011) Vladimir N. Uversky   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Novel Strategies for Drug Discovery Based on Intrinsically Disordered Proteins (IDPs)

(2011) Jihua Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intrinsically disordered proteins are potential drug targets

(2010) Steven J Metallo   CURRENT OPINION IN CHEMICAL BIOLOGY

Drugs for ‘protein clouds’: targeting intrinsically disordered transcription factors

(2010) A Keith Dunker et al.   CURRENT OPINION IN PHARMACOLOGY

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization

(2010) D. M. Clausen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Small-molecule inhibitors of c-Myc transcriptional factor suppress proliferation and induce apoptosis of promyelocytic leukemia cell via cell cycle arrest

(2010) Kyung-Chae Jeong et al.   Molecular BioSystems

Discovery of Novel Myc−Max Heterodimer Disruptors with a Three-Dimensional Pharmacophore Model

(2009) Gabriela Mustata et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kinetic Advantage of Intrinsically Disordered Proteins in Coupled Folding–Binding Process: A Critical Assessment of the “Fly-Casting” Mechanism

(2009) Yongqi Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

(2009) Dalia I. Hammoudeh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The unfoldomics decade: an update on intrinsically disordered proteins

(2008) A Keith Dunker et al.   BMC GENOMICS

Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

(2008) Jianxia Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

(2008) Ariele Viacava Follis et al.   CHEMISTRY & BIOLOGY