Cellular and molecular regulation of the programmed death-1/programmed death ligand system and its role in multiple sclerosis and other autoimmune diseases

Programmed Death-Ligand 2 Deficiency Exacerbates Experimental Autoimmune Myocarditis in Mice

(2021) Siqi Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EGFR‐ERK pathway regulates CSN6 to contribute to PD‐L1 expression in glioblastoma

(2020) Lingrui Su et al.   MOLECULAR CARCINOGENESIS

Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease

(2020) David J. Sherman et al.   MOLECULES

Epigenetically silenced PD-L1 confers drug resistance to anti-PD1 therapy in gastric cardia adenocarcinoma

(2020) Tianyu Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The polymorphism rs975484 in the protein arginine methyltransferase 1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma

(2020) Michael Schonfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PD-1 and PD-L1 Expression in Peripheral CD4/CD8+ T Cells Is Restored in the Partial Remission Phase in Type 1 Diabetes

(2020) Xia Li et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer

(2020) Ge Qin et al.   Nature Communications

Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer

(2020) Shouping Xu et al.   Cancer Immunology Research

PD-1-Mediated PI3K/Akt/mTOR, Caspase 9/Caspase 3 and ERK Pathways Are Involved in Regulating the Apoptosis and Proliferation of CD4+ and CD8+ T Cells During BVDV Infection in vitro

(2020) Yu Liu et al.   Frontiers in Immunology

Progress and Challenges in Precise Treatment of Tumors With PD-1/PD-L1 Blockade

(2020) Youhai Jiang et al.   Frontiers in Immunology

Low expressions of PD-L1 and CTLA-4 by induced CD4+CD25+ Foxp3+ Tregs in patients with SLE and their correlation with the disease activity

(2020) Ling Zhao et al.   CYTOKINE

Membrane-associated epithelial cell adhesion molecule is slowly cleaved by γ-secretase prior to efficient proteasomal degradation of its intracellular domain

(2019) Yuanchi Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells

(2019) Don-Marc Franchini et al.   Cell Reports

Autophagy inhibition enhances PD-L1 expression in gastric cancer

(2019) Xiaojuan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours

(2019) Han Yao et al.   Nature Biomedical Engineering

A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions

(2019) Nisha Bte Mohd Rafiq et al.   NATURE MATERIALS

Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses

(2019) Daisuke Sugiura et al.   SCIENCE

Circulating CXCR5−PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes

(2019) Ilse Ekman et al.   DIABETOLOGIA

The PD-1/PD-Ls pathway is up-regulated during the suppression of experimental autoimmune encephalomyelitis treated by Astragalus polysaccharides

(2019) Yu Sun et al.   JOURNAL OF NEUROIMMUNOLOGY

Progress in PD-1/PD-L1 pathway inhibitors: From biomacromolecules to small molecules

(2019) Xin Lin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation

(2019) Wenfang Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Dendritic cell upregulation of programmed death ligand-1 via DNA demethylation inhibits experimental autoimmune encephalomyelitis

(2019) Chia-Bin Chang et al.   JOURNAL OF AUTOIMMUNITY

Glucocorticoids potentiate the inhibitory capacity of programmed cell death 1 by up-regulating its expression on T cells

(2019) Natsumi Maeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE

(2019) Hilary A. Seifert et al.   Journal of Neuroinflammation

Myeloid maturation potentiates STAT3-mediated atypical IFN-γ signaling and upregulation of PD-1 ligands in AML and MDS

(2019) Digdem Yoyen-Ermis et al.   Scientific Reports

Mechanisms regulating PD-L1 expression on tumor and immune cells

(2019) Shuming Chen et al.   Journal for ImmunoTherapy of Cancer

Interferon-β corrects massive gene dysregulation in multiple sclerosis: Short-term and long-term effects on immune regulation and neuroprotection

(2019) Xuan Feng et al.   EBioMedicine

The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals

(2019) Elliot A. Philips et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PD-1 Expression during Acute Infection Is Repressed through an LSD1–Blimp-1 Axis

(2019) Alexander P. R. Bally et al.   JOURNAL OF IMMUNOLOGY

The change of PD1, PDL1 in experimental autoimmune encephalomyelitis treated by 1,25(OH)2D3

(2019) Qingqing Cao et al.   JOURNAL OF NEUROIMMUNOLOGY

c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth

(2019) Chimera Lyle et al.   Scientific Reports

T follicular-like helper cells in the peripheral blood of patients with primary Sjögren's syndrome

(2018) K. A. Brokstad et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

FoxP3 isoforms and PD-1 expression by T regulatory cells in multiple sclerosis

(2018) Manolo Sambucci et al.   Scientific Reports

Innate IFN-γ ameliorates experimental autoimmune encephalomyelitis and promotes myeloid expansion and PDL-1 expression

(2018) Madeleine P. J. White et al.   Scientific Reports

Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation

(2018) James L. Quinn et al.   Frontiers in Immunology

T Follicular Helper-Like Cells Are Involved in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2018) Jun Guo et al.   Frontiers in Immunology

H3K4me3 mediates the NF-κB p50 homodimer binding to the pdcd1 promoter to activate PD-1 transcription in T cells

(2018) Priscilla S. Redd et al.   OncoImmunology

PD-1 ( PDCD1 ) Promoter Methylation Is a Prognostic Factor in Patients With Diffuse Lower-Grade Gliomas Harboring Isocitrate Dehydrogenase ( IDH ) Mutations

(2018) Lea Kristin Röver et al.   EBioMedicine

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

(2018) Chaido Stathopoulou et al.   IMMUNITY

Increased circulating Tfh17 and PD-1+Tfh cells are associated with autoantibodies in Hashimoto’s thyroiditis

(2018) Jiwei Zhao et al.   AUTOIMMUNITY

BCL6-Mediated Silencing of PD-1 Ligands in Germinal Center B Cells Maintains Follicular T Cell Population

(2018) Cheng Peng et al.   JOURNAL OF IMMUNOLOGY

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells

(2018) Xiangbo Meng et al.   NATURE

HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity

(2018) Huanbin Wang et al.   Nature Chemical Biology

T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses

(2018) Alireza Saeidi et al.   Frontiers in Immunology

Transcription Factor IRF4 Promotes CD8 + T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

(2017) Kevin Man et al.   IMMUNITY

PD-1 and cancer: molecular mechanisms and polymorphisms

(2017) Arash Salmaninejad et al.   IMMUNOGENETICS

The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint

(2017) Qingshui Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PD-1 gene polymorphic variation is linked with first symptom of disease and severity of relapsing-remitting form of MS

(2017) Edyta Pawlak-Adamska et al.   JOURNAL OF NEUROIMMUNOLOGY

Contribution of EAE to understanding and treating multiple sclerosis

(2017) Amy E. Lovett-Racke   JOURNAL OF NEUROIMMUNOLOGY

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes

(2017) Moufida Ben Nasr et al.   Science Translational Medicine

Meta-analysis of programmed cell death 1 polymorphisms with systemic lupus erythematosus risk

(2017) Jie Gao et al.   Oncotarget

Soluble PD-1 and PD-L1: predictive and prognostic significance in cancer

(2017) Xinxin Zhu et al.   Oncotarget

Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells

(2017) Masahiro Okada et al.   Cell Reports

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Update on Dendritic Cell-Induced Immunological and Clinical Tolerance

(2017) Carolina Obregon et al.   Frontiers in Immunology

Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes

(2017) Hector M. Granados et al.   PLoS One

PD-1/PD-L and autoimmunity: A growing relationship

(2016) Mohammad Reza Zamani et al.   CELLULAR IMMUNOLOGY

Circulating CXCR5 + PD-1 + ICOS + Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies

(2016) Tyyne Viisanen et al.   DIABETES

Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8+ Cytolytic T Cell Responses

(2016) Alison Taylor et al.   IMMUNITY

The role of B7 family costimulatory molecules and indoleamine 2,3-dioxygenase in primary Sjögren’s syndrome and systemic sclerosis

(2016) Nóra Legány et al.   IMMUNOLOGIC RESEARCH

Programmed Death Ligand-1 on Microglia Regulates Th1 Differentiation via Nitric Oxide in Experimental Autoimmune Encephalomyelitis

(2016) Jingxia Hu et al.   Neuroscience Bulletin

A comprehensive investigation on the distribution of circulating follicular T helper cells and B cell subsets in primary Sjögren's syndrome and systemic lupus erythematosus

(2015) K. Szabó et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A basic overview of multiple sclerosis immunopathology

(2015) N. Grigoriadis et al.   EUROPEAN JOURNAL OF NEUROLOGY

β-Cell-targeted blockage of PD1 and CTLA4 pathways prevents development of autoimmune diabetes and acute allogeneic islets rejection

(2015) M M El Khatib et al.   GENE THERAPY

Imaging of Cell–Cell Communication in a Vertical Orientation Reveals High-Resolution Structure of Immunological Synapse and Novel PD-1 Dynamics

(2015) Joon Hee Jang et al.   JOURNAL OF IMMUNOLOGY

Association of circulating follicular helper T cells with disease course of NMO spectrum disorders

(2015) Yu-Jing Li et al.   JOURNAL OF NEUROIMMUNOLOGY

The programmed cell death 1 gene polymorphisms (PD 1.3 G/A, PD 1.5 C/T and PD 1.9 C/T) and susceptibility to ankylosing spondylitis: a meta-analysis

(2015) Mingyuan Yang et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Soluble PD-1 aggravates progression of collagen-induced arthritis through Th1 and Th17 pathways

(2015) Cuiping Liu et al.   ARTHRITIS RESEARCH & THERAPY

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Hypomethylation and up-regulation of PD-1 in T cells by azacytidine in MDS/AML patients: A rationale for combined targeting of PD-1 and DNA methylation

(2015) Andreas D. Ørskov et al.   Oncotarget

HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade

(2015) D. M. Woods et al.   Cancer Immunology Research

Stage-Specific Role of Interferon-Gamma in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

(2015) Gabriel Arellano et al.   Frontiers in Immunology

Opposing Roles of Interferon-Gamma on Cells of the Central Nervous System in Autoimmune Neuroinflammation

(2015) Payton A. Ottum et al.   Frontiers in Immunology

Programmed death-1 pathway in cancer and autoimmunity

(2014) Ariel Pedoeem et al.   CLINICAL IMMUNOLOGY

Protective effects of Fc-fused PD-L1 on two different animal models of colitis

(2014) Mi-Young Song et al.   GUT

Programmed Death Ligand 1 Regulates a Critical Checkpoint for Autoimmune Myocarditis and Pneumonitis in MRL Mice

(2014) J. A. Lucas et al.   JOURNAL OF IMMUNOLOGY

Synovial T cell hyporesponsiveness to myeloid dendritic cells is reversed by preventing PD-1/PD-L1 interactions

(2014) Frederique M Moret et al.   ARTHRITIS RESEARCH & THERAPY

Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome

(2013) Krisztina Szabo et al.   CLINICAL IMMUNOLOGY

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

(2013) Jing He et al.   IMMUNITY

Blockade of Programmed Death-1 in Young (New Zealand Black x New Zealand White)F1 Mice Promotes the Suppressive Capacity of CD4+ Regulatory T Cells Protecting from Lupus-like Disease

(2013) M. Wong et al.   JOURNAL OF IMMUNOLOGY

Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis

(2013) Chuanming Luo et al.   JOURNAL OF NEUROIMMUNOLOGY

Self-tolerance in multiple sclerosis

(2012) R. E. Gonsette   ACTA NEUROLOGICA BELGICA

Role of the frequency of blood CD4+ CXCR5+ CCR6+ T cells in autoimmunity in patients with Sjögren’s syndrome

(2012) Xue-yi Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity

(2012) Suzanne L Topalian et al.   CURRENT OPINION IN IMMUNOLOGY

Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

(2012) Nir Yogev et al.   IMMUNITY

Immune checkpoints in central nervous system autoimmunity

(2012) Nicole Joller et al.   IMMUNOLOGICAL REVIEWS

Pharmacology and therapeutic potential of interferons

(2012) Peter M. George et al.   PHARMACOLOGY & THERAPEUTICS

The role of the PD-1 pathway in autoimmunity and peripheral tolerance

(2011) Brian T. Fife et al.   Annals of the New York Academy of Sciences

Identification of a Soluble Form of B7-H1 That Retains Immunosuppressive Activity and Is Associated with Aggressive Renal Cell Carcinoma

(2011) X. Frigola et al.   CLINICAL CANCER RESEARCH

The majority of infiltrating CD8 T lymphocytes in multiple sclerosis lesions is insensitive to enhanced PD-L1 levels on CNS cells

(2011) Camille L. Pittet et al.   GLIA

IFN-  Directly Promotes Programmed Cell Death-1 Transcription and Limits the Duration of T Cell-Mediated Immunity

(2011) S. Terawaki et al.   JOURNAL OF IMMUNOLOGY

Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis

(2011) Camille L Pittet et al.   Journal of Neuroinflammation

PD-1 deficiency results in the development of fatal myocarditis in MRL mice

(2010) Jian Wang et al.   INTERNATIONAL IMMUNOLOGY

Anti-Programmed Cell Death 1 Antibody Reduces CD4 + PD-1 + T Cells and Relieves the Lupus-Like Nephritis of NZB/W F1 Mice

(2010) Shimpei Kasagi et al.   JOURNAL OF IMMUNOLOGY

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

(2010) Kim L Good-Jacobson et al.   NATURE IMMUNOLOGY

Accelerated Course of Experimental Autoimmune Encephalomyelitis in PD-1-Deficient Central Nervous System Myelin Mutants

(2009) Antje Kroner et al.   AMERICAN JOURNAL OF PATHOLOGY

Genetic, immunologic, and immunohistochemical analysis of the programmed death 1/programmed death ligand 1 pathway in human systemic lupus erythematosus

(2009) George K. Bertsias et al.   ARTHRITIS AND RHEUMATISM

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

(2009) Nicholas Simpson et al.   ARTHRITIS AND RHEUMATISM

Programmed Death Ligand 1 (PD-L1) Gene Variants Contribute to Autoimmune Addison’s Disease and Graves’ Disease Susceptibility

(2009) Anna L. Mitchell et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Costimulatory Pathways in Multiple Sclerosis: Distinctive Expression of PD-1 and PD-L1 in Patients with Different Patterns of Disease

(2009) D. Trabattoni et al.   JOURNAL OF IMMUNOLOGY

Estrogen treatment in multiple sclerosis

(2009) Stefan M. Gold et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

(2009) Brian T Fife et al.   NATURE IMMUNOLOGY

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 gene with Graves' disease in Japanese patients.

(2008) Mina Hayashi et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: Implications for the lesion pathogenesis of multiple sclerosis

(2008) Sonja Ortler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE

(2008) Bettina Schreiner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Oestrogen modulates experimental autoimmune encephalomyelitis and interleukin-17 production via programmed death 1

(2008) Chunhe Wang et al.   IMMUNOLOGY

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active systemic lupus erythematosus is associated with failure of antigen-presenting cells to express programmed death ligand-1

(2008) N. Mozaffarian et al.   RHEUMATOLOGY