Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
出版年份 2018 全文链接
标题
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
作者
关键词
Alzheimer’s disease, Amyloid beta, Plaques, Intraneuronal amyloid, Microglia, Neuroinflammation
出版物
Molecular Neurodegeneration
Volume 13, Issue 1, Pages -
出版商
Springer Nature
发表日期
2018-03-01
DOI
10.1186/s13024-018-0244-x
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Microglia in Alzheimer’s disease
- (2017) Heela Sarlus et al. JOURNAL OF CLINICAL INVESTIGATION
- Microglia emerge as central players in brain disease
- (2017) Michael W Salter et al. NATURE MEDICINE
- Structural differences between amyloid beta oligomers
- (2016) Leonid Breydo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology
- (2016) Elizabeth E. Spangenberg et al. BRAIN
- Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke
- (2016) Gergely Szalay et al. Nature Communications
- Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System
- (2015) Julia Bruttger et al. IMMUNITY
- Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease
- (2015) Sagar H. Barage et al. NEUROPEPTIDES
- Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines
- (2014) Daniela Puzzo et al. BIOCHEMICAL PHARMACOLOGY
- Native metastable prefibrillar oligomers are the most neurotoxic species among amyloid aggregates
- (2014) Marco Diociaiuti et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Monoclonal Antibodies against Aβ42 Fibrils Distinguish Multiple Aggregation State Polymorphismsin Vitroand in Alzheimer Disease Brain
- (2014) Asa Hatami et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain
- (2014) Monica R.P. Elmore et al. NEURON
- Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival
- (2013) Jian Luo et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation
- (2013) William A Eimer et al. Molecular Neurodegeneration
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- Alzheimer's Disease: Critical Notes on the History of a Medical Concept
- (2012) Jesus Ramirez-Bermudez ARCHIVES OF MEDICAL RESEARCH
- Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers
- (2011) Rakez Kayed et al. Molecular Neurodegeneration
- Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity
- (2011) Stéphane P. Poulin et al. PSYCHIATRY RESEARCH-NEUROIMAGING
- Mechanism of amyloid plaque formation suggests an intracellular basis of A pathogenicity
- (2010) R. P. Friedrich et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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