The Kynurenine Pathway—New Linkage between Innate and Adaptive Immunity in Autoimmune Endocrinopathies

NK Cells in Autoimmune Diseases: Protective or Pathogenic?

(2021) Meifang Liu et al.   Frontiers in Immunology

Revisiting the Antigen-Presenting Function of β Cells in T1D Pathogenesis

(2021) Yang Li et al.   Frontiers in Immunology

Graves' disease: Clinical manifestations, immune pathogenesis (cytokines and chemokines) and therapy

(2020) Alessandro Antonelli et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Evolutionary Views of Tuberculosis: Indoleamine 2,3‐Dioxygenase Catalyzed Nicotinamide Synthesis Reflects Shifts in Macrophage Metabolism

(2020) Melinda S. Suchard et al.   BIOESSAYS

Role of DNA-LL37 complexes in the activation of plasmacytoid dendritic cells and monocytes in subjects with type 1 diabetes

(2020) Darshan Badal et al.   Scientific Reports

Prunella vulgaris L. attenuates experimental autoimmune thyroiditis by inducing indoleamine 2,3-dioxygenase 1 expression and regulatory T cell expansion

(2020) Huanbing Qiu et al.   BIOMEDICINE & PHARMACOTHERAPY

Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes

(2020) Lin Sun et al.   Journal of Diabetes Research

The AHR Signaling Attenuates Autoimmune Responses During the Development of Type 1 Diabetes

(2020) Tiantian Yue et al.   Frontiers in Immunology

The effect of environmental pollution on immune evasion checkpoints of SARS-CoV-2

(2020) Ayse Basak Engin et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Treg Enhancing Therapies to Treat Autoimmune Diseases

(2020) Peter J. Eggenhuizen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses

(2020) Lauren M. F. Merlo et al.   Frontiers in Immunology

Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)

(2020) Bart O. Roep et al.   Nature Reviews Endocrinology

Immunological pathogenesis and treatment of systemic lupus erythematosus

(2019) Lu Pan et al.   World Journal of Pediatrics

Amino acid metabolism as drug target in autoimmune diseases

(2019) Giada Mondanelli et al.   AUTOIMMUNITY REVIEWS

Autoimmune Pancreatitis Type 2

(2019) Rajib Gupta et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Islet‐Immune Interactions in Type 1 Diabetes: The Nexus of Beta Cell Destruction

(2019) Leeana Peters et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review

(2019) Jeroen M.k. de Filette et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Thyroid autoimmune disorders and cancer

(2019) Silvia Martina Ferrari et al.   SEMINARS IN CANCER BIOLOGY

Epidemiology, pathogenesis, and diagnosis of Addison’s disease in adults

(2019) C. Betterle et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

The Role of Monocytes and Macrophages in Autoimmune Diseases: A Comprehensive Review

(2019) Wen-Tao Ma et al.   Frontiers in Immunology

Adaptive and Innate Immunity in Psoriasis and Other Inflammatory Disorders

(2019) Michael P. Schön   Frontiers in Immunology

Indoleamine-2,3-Dioxygenase in Thyroid Cancer Cells Suppresses Natural Killer Cell Function by Inhibiting NKG2D and NKp46 Expression via STAT Signaling Pathways

(2019) Arum Park et al.   Journal of Clinical Medicine

Stimulator of Interferon Genes Agonists attenuate type I diabetes progression in NOD mice

(2019) Henrique Lemos et al.   IMMUNOLOGY

Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells

(2019) Christopher J.M. Piper et al.   Cell Reports

Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target

(2019) Freek J. H. Sorgdrager et al.   Frontiers in Immunology

Increase in circulating cells coexpressing M1 and M2 macrophage surface markers in patients with systemic sclerosis

(2018) Stefano Soldano et al.   ANNALS OF THE RHEUMATIC DISEASES

NK cells in autoimmune diseases: Linking innate and adaptive immune responses

(2018) Elena Gianchecchi et al.   AUTOIMMUNITY REVIEWS

Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes

(2018) Florence Anquetil et al.   DIABETES

IDO decreases glycolysis and glutaminolysis by activating GCN2K, while it increases fatty acid oxidation by activating AhR, thus preserving CD4+ T‑cell survival and proliferation

(2018) Theodoros Eleftheriadis et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Autoimmune Polyendocrine Syndromes

(2018) Eystein S. Husebye et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase—Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases

(2018) Li Bo et al.   Frontiers in Immunology

Malaria Systems Immunology: Plasmodium vivax induces tolerance during primary infection through dysregulation of neutrophils and dendritic cells

(2018) Andres F. Vallejo et al.   JOURNAL OF INFECTION

Pancreas Volume Declines During the First Year After Diagnosis of Type 1 Diabetes and Exhibits Altered Diffusion at Disease Onset

(2018) John Virostko et al.   DIABETES CARE

The challenge of modulating β-cell autoimmunity in type 1 diabetes

(2018) Mark A Atkinson et al.   Lancet Diabetes & Endocrinology

Increased quinolinic acid in peripheral mononuclear cells in Alzheimer’s dementia

(2017) Mandy Busse et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Neurotransmitter signalling via NMDA receptors leads to decreased T helper type 1-like and enhanced T helper type 2-like immune balance in humans

(2017) Kanami Orihara et al.   IMMUNOLOGY

IL-21 May Promote Granzyme B-Dependent NK/Plasmacytoid Dendritic Cell Functional Interaction in Cutaneous Lupus Erythematosus

(2017) Valentina Salvi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Kynurenic acid downregulates IL-17/1L-23 axis in vitro

(2017) Sanam Salimi Elizei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Tryptophan availability for kynurenine pathway metabolism across the life span: Control mechanisms and focus on aging, exercise, diet and nutritional supplements

(2017) Abdulla A-B. Badawy   NEUROPHARMACOLOGY

Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

(2017) Igor Cervenka et al.   SCIENCE

Human limbal fibroblast-like stem cells induce immune-tolerance in autoreactive T lymphocytes from female patients with Hashimoto’s thyroiditis

(2017) Antonina Coppola et al.   Stem Cell Research & Therapy

STATs in NK-Cells: The Good, the Bad, and the Ugly

(2017) Dagmar Gotthardt et al.   Frontiers in Immunology

The Proteasome Inhibitor Bortezomib Controls Indoleamine 2,3-Dioxygenase 1 Breakdown and Restores Immune Regulation in Autoimmune Diabetes

(2017) Giada Mondanelli et al.   Frontiers in Immunology

Neonatal immune response to rhinovirus A16 has diminished dendritic cell function and increased B cell activation

(2017) Amanda Barlow-Anacker et al.   PLoS One

Prediction and Prevention of Autoimmune Disease in the 21st Century: A Review and Preview

(2016) Noel R. Rose   AMERICAN JOURNAL OF EPIDEMIOLOGY

The immune system

(2016) L. B. Nicholson   Essays in Biochemistry

A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus

(2016) Madhvi Menon et al.   IMMUNITY

Innate immunity in vertebrates: an overview

(2016) Mario Riera Romo et al.   IMMUNOLOGY

Local Generation of Kynurenines Mediates Inhibition of Neutrophil Chemotaxis by Uropathogenic Escherichia coli

(2016) Jennifer A. Loughman et al.   INFECTION AND IMMUNITY

CD4+T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm

(2016) Kiyoshi Hirahara et al.   INTERNATIONAL IMMUNOLOGY

Indoleamine 2,3-dioxygenase, by degrading L-tryptophan, enhances carnitine palmitoyltransferase I activity and fatty acid oxidation, and exerts fatty acid-dependent effects in human alloreactive CD4+ T-cells

(2016) Theodoros Eleftheriadis et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

IDO-Expressing Fibroblasts Protect Islet Beta Cells From Immunological Attack and Reverse Hyperglycemia in Non-Obese Diabetic Mice

(2016) Yun Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tolerogenic Phenotype of IFN-γ–Induced IDO+Dendritic Cells Is Maintained via an Autocrine IDO–Kynurenine/AhR–IDO Loop

(2016) Qingsheng Li et al.   JOURNAL OF IMMUNOLOGY

Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2016) Kira Meyerovich et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection

(2016) Xavier Dagenais-Lussier et al.   JOURNAL OF VIROLOGY

Characterization of the Kynurenine Pathway in CD8+ Human Primary Monocyte-Derived Dendritic Cells

(2016) Nady Braidy et al.   NEUROTOXICITY RESEARCH

Graves’ Disease

(2016) Terry J. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric Vaccine Stimulation of Human Dendritic Cell Indoleamine 2, 3-Dioxygenase Occurs via the Non-Canonical NF-κB Pathway

(2016) Nan-Sun Kim et al.   PLoS One

The role of neutrophils in inflammation resolution

(2016) Hefin R. Jones et al.   SEMINARS IN IMMUNOLOGY

Oral Probiotic VSL#3 Prevents Autoimmune Diabetes by Modulating Microbiota and Promoting Indoleamine 2,3-Dioxygenase-Enriched Tolerogenic Intestinal Environment

(2016) Jayashree Dolpady et al.   Journal of Diabetes Research

Phenotypic, Functional, and Plasticity Features of Classical and Alternatively Activated Human Macrophages

(2015) Abdullah A. Tarique et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Autoimmune thyroid disorders

(2015) Alessandro Antonelli et al.   AUTOIMMUNITY REVIEWS

Role of indoleamine 2,3-dioxygenase in health and disease

(2015) Amanda W.S. Yeung et al.   CLINICAL SCIENCE

T cell subsets and their signature cytokines in autoimmune and inflammatory diseases

(2015) Itay Raphael et al.   CYTOKINE

Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association

(2015) Richard A. Insel et al.   DIABETES CARE

Predicting Type 1 Diabetes Using Biomarkers

(2015) Ezio Bonifacio   DIABETES CARE

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study

(2015) Jeffrey P. Krischer et al.   DIABETOLOGIA

Natural Killer Cell Memory

(2015) Timothy E. O’Sullivan et al.   IMMUNITY

Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+T cells

(2015) Theodoros Eleftheriadis et al.   IMMUNOLOGY

B-Cells induce regulatory T cells through TGF-β/IDO production in A CTLA-4 dependent manner

(2015) A. Nouël et al.   JOURNAL OF AUTOIMMUNITY

Human autoimmune diseases: a comprehensive update

(2015) Lifeng Wang et al.   JOURNAL OF INTERNAL MEDICINE

Role of the innate and adaptive immune responses in the course of multiple sclerosis

(2015) Bernhard Hemmer et al.   LANCET NEUROLOGY

Indoleamine 2,3-dioxygenase downregulates T-cell receptor complex ζ-chain and c-Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T-cells

(2015) THEODOROS ELEFTHERIADIS et al.   Molecular Medicine Reports

Genetic and environmental factors affect the onset of type 1 diabetes mellitus

(2015) Emma Altobelli et al.   PEDIATRIC DIABETES

Basic biology and role of interleukin-17 in immunity and inflammation

(2015) Camille Zenobia et al.   PERIODONTOLOGY 2000

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

(2015) Philipp Kruger et al.   PLoS Pathogens

The role of indoleamine 2,3-dioxygenase (IDO) in immune tolerance: Focus on macrophage polarization of THP-1 cells

(2014) Xian-Feng Wang et al.   CELLULAR IMMUNOLOGY

Activation of the aryl hydrocarbon receptor affects activation and function of human monocyte-derived dendritic cells

(2014) C. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Human fibrocytic myeloid-derived suppressor cells express IDO and promote tolerance via Treg-cell expansion

(2014) Alessia Zoso et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes

(2014) Maria Teresa Pallotta et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Indoleamine 2,3-Dioxygenase 1 (IDO1) Is Up-Regulated in Thyroid Carcinoma and Drives the Development of an Immunosuppressant Tumor Microenvironment

(2014) Sonia Moretti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGF -Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis

(2014) M.-L. Chen et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Autocrine TGF-  Sustains Default Tolerogenesis by IDO-Competent Dendritic Cells

(2014) M. L. Belladonna et al.   JOURNAL OF IMMUNOLOGY

IL-10: The Master Regulator of Immunity to Infection

(2014) Kevin N. Couper et al.   JOURNAL OF IMMUNOLOGY

Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity

(2014) J. Lee et al.   JOURNAL OF IMMUNOLOGY

IDO2 Is a Critical Mediator of Autoantibody Production and Inflammatory Pathogenesis in a Mouse Model of Autoimmune Arthritis

(2014) L. M. F. Merlo et al.   JOURNAL OF IMMUNOLOGY

An aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress the Th17 response in allergic rhinitis patients

(2014) Ping Wei et al.   LABORATORY INVESTIGATION

Mesenchymal stromal cells infusions improve refractory chronic graft versus host disease through an increase of CD5+ regulatory B cells producing interleukin 10

(2014) Y Peng et al.   LEUKEMIA

Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice

(2014) Francesco Fazio et al.   NEUROPHARMACOLOGY

Diagnosis and management of thyrotoxicosis

(2014) B. Vaidya et al.   BMJ-British Medical Journal

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Autoimmune polyendocrine syndromes

(2013) Maurizio Cutolo   AUTOIMMUNITY REVIEWS

Interleukin 21-Induced Granzyme B-Expressing B Cells Infiltrate Tumors and Regulate T Cells

(2013) S. Lindner et al.   CANCER RESEARCH

IL-17 family: Cytokines, receptors and signaling

(2013) Chunfang Gu et al.   CYTOKINE

Protection Against Type 1 Diabetes Upon Coxsackievirus B4 Infection and iNKT-Cell Stimulation: Role of Suppressive Macrophages

(2013) L. Ghazarian et al.   DIABETES

Interleukin 17 contributes to the chronicity of inflammatory diseases such as rheumatoid arthritis

(2013) Giulia Benedetti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natural cytotoxicity receptors and their ligands

(2013) Philip H Kruse et al.   IMMUNOLOGY AND CELL BIOLOGY

The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes

(2013) Andrea Niño-Castro et al.   Innate Immunity

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children

(2013) Anette G. Ziegler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Plasmacytoid Dendritic Cells in Patients With Autoimmune Thyroid Disease

(2013) Susanna Leskela et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: Cytokine challenge increases production of 3-hydroxykynurenine

(2013) Anne-Sofie Johansson et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Immunopathogenic mechanisms of systemic autoimmune disease

(2013) Marie Wahren-Herlenius et al.   LANCET

Immuno-Regulatory Function of Indoleamine 2,3 Dioxygenase through Modulation of Innate Immune Responses

(2013) Malihe-Sadat Poormasjedi-Meibod et al.   PLoS One

Regulatory B Cells and Tolerance in Transplantation: From Animal Models to Human

(2013) Mélanie Chesneau et al.   Frontiers in Immunology

IL-10 Producing Regulatory B Cells in Mice and Humans: State of the Art

(2012) J. -D. Bouaziz et al.   CURRENT MOLECULAR MEDICINE

Neutrophil – CD4+CD25+ T regulatory cell interactions: A possible new mechanism of infectious tolerance

(2012) Natalia Lewkowicz et al.   IMMUNOBIOLOGY

Indoleamine 2,3-Dioxygenase and Dendritic Cell Tolerogenicity

(2012) Jamie L Harden et al.   IMMUNOLOGICAL INVESTIGATIONS

Induction of Indoleamine 2,3-Dioxygenase by Uropathogenic Bacteria Attenuates Innate Responses to Epithelial Infection

(2012) Jennifer A. Loughman et al.   JOURNAL OF INFECTIOUS DISEASES

Natural CD4+ T-Cell Responses against Indoleamine 2,3-Dioxygenase

(2012) Shamaila Munir et al.   PLoS One

Mechanism Underlying Defective Interferon Gamma-Induced IDO Expression in Non-obese Diabetic Mouse Fibroblasts

(2012) Azadeh Hosseini-Tabatabaei et al.   PLoS One

Correction: Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression

(2012) Irene Tirado-González et al.   PLoS One

Plasmacytoid Dendritic Cells Protect Against Atherosclerosis by Tuning T-Cell Proliferation and Activity

(2011) Isabelle T.M.N. Daissormont et al.   CIRCULATION RESEARCH

Induction of regulatory T cells by green tea polyphenol EGCG

(2011) Carmen P. Wong et al.   IMMUNOLOGY LETTERS

Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation

(2011) D. S. Abi Abdallah et al.   INTERNATIONAL IMMUNOLOGY

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

(2011) Janesh Pillay et al.   JOURNAL OF CLINICAL INVESTIGATION

Physiologic Control of IDO Competence in Splenic Dendritic Cells

(2011) B. Baban et al.   JOURNAL OF IMMUNOLOGY

The kynurenine system and immunoregulation

(2011) Yvette Mándi et al.   JOURNAL OF NEURAL TRANSMISSION

Attenuation of human neutrophil migration and function by uropathogenic bacteria

(2011) Jennifer A. Loughman et al.   MICROBES AND INFECTION

IDO expression by human B lymphocytes in response to T lymphocyte stimuli and TLR engagement is biologically inactive

(2011) Jessica Godin-Ethier et al.   MOLECULAR IMMUNOLOGY

Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C

(2011) A K Smith et al.   MOLECULAR PSYCHIATRY

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

Identification of a Variable Number of Tandem Repeats Polymorphism and Characterization of LEF-1 Response Elements in the Promoter of the IDO1 Gene

(2011) Marion Soichot et al.   PLoS One

Type 1 regulatory T cells (Tr1) in autoimmunity

(2011) Caroline Pot et al.   SEMINARS IN IMMUNOLOGY

TGF-  Receptor II Loss Promotes Mammary Carcinoma Progression by Th17-Dependent Mechanisms

(2011) S. V. Novitskiy et al.   Cancer Discovery

Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism

(2010) Gregory F. Oxenkrug   Annals of the New York Academy of Sciences

Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation

(2010) In Duk Jung et al.   BIOCHEMICAL PHARMACOLOGY

Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators

(2010) R. B. Sorensen et al.   BLOOD

Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease

(2010) S. S. De Ravin et al.   BLOOD

The eosinophil and airway remodelling in asthma

(2010) Per Venge   Clinical Respiratory Journal

Regulation in chronic obstructive pulmonary disease: the role of regulatory T-cells and Th17 cells

(2010) Nina Lane et al.   CLINICAL SCIENCE

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

(2010) T. I. M. Tree et al.   DIABETES

Tryptophan metabolite 3-hydroxyanthranilic acid selectively induces activated T cell death via intracellular GSH depletion

(2010) Sun-Mi Lee et al.   IMMUNOLOGY LETTERS

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Immunity, thyroid function and pregnancy: molecular mechanisms

(2010) Anthony P. Weetman   Nature Reviews Endocrinology

Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host

(2010) Didier Hober et al.   Nature Reviews Endocrinology

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis

(2010) F. J. Quintana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

Thymic Indoleamine 2,3-Dioxygenase-Positive Eosinophils in Young Children

(2009) Meri K. Tulic et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulatory B Cells in Autoimmune Diseases

(2009) Sébastien Lemoine et al.   Annals of the New York Academy of Sciences

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes

(2009) M. D. Sharma et al.   BLOOD

Plasmacytoid dendritic cells in autoimmune diabetes – Potential tools for immunotherapy

(2009) Tatjana Nikolic et al.   IMMUNOBIOLOGY

Functional Role of Eosinophils in Gastrointestinal Inflammation

(2009) Simon P. Hogan   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

(2009) Akihiro Kimura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone

(2009) Francesca Fallarino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PDCA Expression by B Lymphocytes Reveals Important Functional Attributes

(2009) D. S. Vinay et al.   JOURNAL OF IMMUNOLOGY

The Immunoregulatory Enzyme IDO Paradoxically Drives B Cell-Mediated Autoimmunity

(2009) G. N. Scott et al.   JOURNAL OF IMMUNOLOGY

IDO Mediates TLR9-Driven Protection from Experimental Autoimmune Diabetes

(2009) F. Fallarino et al.   JOURNAL OF IMMUNOLOGY

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

The Immune System Strikes Back: Cellular Immune Responses against Indoleamine 2,3-dioxygenase

(2009) Rikke Bæk Sørensen et al.   PLoS One

TGF-β and kynurenines as the key to infectious tolerance

(2009) Maria L. Belladonna et al.   TRENDS IN MOLECULAR MEDICINE

Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice

(2009) Masaaki Kanai et al.   Molecular Brain

Tryptophan catabolites regulate mucosal sensitization to ovalbumin in respiratory airways

(2008) S. O. Odemuyiwa et al.   ALLERGY

Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase

(2008) Christoph F.A. Vogel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transforming Growth Factor-  Suppresses the Activation of CD8+ T-Cells When Naive but Promotes Their Survival and Function Once Antigen Experienced: A Two-Faced Impact on Autoimmunity

(2008) C. M. Filippi et al.   DIABETES

Expression of Immunoregulatory Molecules by Thyrocytes Protects Nonobese Diabetic-H2h4Mice from Developing Autoimmune Thyroiditis

(2008) Mami Nakahara et al.   ENDOCRINOLOGY

Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase

(2008) Alberto Molano et al.   IMMUNOLOGY LETTERS

Human Eosinophils Show Chemotaxis to Lymphoid Chemokines and Exhibit Antigen-Presenting-Cell-Like Properties upon Stimulation with IFN-γ, IL-3 and GM-CSF

(2008) Yun-Jae Jung et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

TGF-β and Regulatory T Cell in Immunity and Autoimmunity

(2008) Yisong Y. Wan et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Dynamics of Neutrophil Infiltration during Cutaneous Wound Healing and Infection Using Fluorescence Imaging

(2008) Min-Ho Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially

(2008) L. A. Spencer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE

Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells

(2008) Louise J Young et al.   NATURE IMMUNOLOGY

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation

(2008) H. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils

(2007) Patrizia Scapini et al.   IMMUNOLOGY LETTERS