Article
Biochemistry & Molecular Biology
Narayanan Puthillathu Vasudevan, Dharmendra K. Soni, John R. Moffett, Jishnu K. S. Krishnan, Abhilash P. Appu, Sarani Ghoshal, Peethambaran Arun, John M. Denu, Thomas P. Flagg, Roopa Biswas, Aryan M. Namboodiri
Summary: The acetate activating enzyme Acss2 plays a role in matching cellular metabolism to current conditions and has regulatory functions in addition to its role in lipid synthesis. Using Acss2 knockout mice, this study investigated the roles of Acss2 in liver, brain, and adipose tissue and found dysregulation of numerous signaling pathways and cellular processes. The loss of Acss2 resulted in few changes in fatty acid constitution in these organ systems. Overall, this research demonstrates the organ-specific transcriptional regulatory patterns of Acss2 and its role as a regulatory enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Monica Dominguez, Bernhard Bruene, Dmitry Namgaladze
Summary: Recent studies have shown the profound influence of metabolism on immune responses, particularly through epigenetic regulation of gene expression. ACLY plays a crucial role in the formation of cytosolic acetyl-CoA, supporting de novo lipogenesis and contributing to epigenetic regulation through histone acetylation. Alternative sources of acetyl-CoA also play a role in metabolic and epigenetic regulation in immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Battsetseg Batchuluun, Stephen L. Pinkosky, Gregory R. Steinberg
Summary: Fatty acids play essential roles in cellular survival and function as bioenergetic substrates, structural components, and signaling molecules. Cells have evolved de novo lipogenesis (DNL) to generate fatty acids from alternative carbon sources. However, abnormal upregulation of DNL is associated with various pathologies. Inhibiting core enzymes of DNL represents a potential therapeutic strategy, and several synthetic DNL inhibitors are currently in development. Aberrant upregulation of DNL is implicated in conditions such as cardiovascular disease, metabolic disorders, and cancers.
NATURE REVIEWS DRUG DISCOVERY
(2022)
Article
Biology
Jingbo Ma, Yang Gu, Peng Xu
Summary: This study reports a systematic approach to improve the biosynthesis of the cannabinoid precursor olivetolic acid in yeast, leading to a significant increase in the production of the acid. The findings provide a baseline for engineering cannabinoids biosynthesis in oleaginous yeast species.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Medicinal
Yongjun Zang, Luyang Tai, Yuanyang Hu, Yu Wang, Hongbin Sun, Xiaoan Wen, Haoliang Yuan, Liang Dai
Summary: A novel macrocyclic compound 2 with potent ACLY inhibitory activity and improved metabolic stability has been identified, highlighting its potential as a lead compound worthy of further study.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Chemistry, Multidisciplinary
Nirmalya Pradhan, Nasim Akhtar, Barnali Nath, Jorge Pena-Garcia, Anjali Gupta, Horacio Perez-Sanchez, Sachin Kumar, Debasis Manna
Summary: Quinine derivatives effectively inhibit the activity of IDO1 by competing with heme, providing a potential avenue for immunotherapy-based drug discovery strategies.
CHEMICAL COMMUNICATIONS
(2021)
Review
Oncology
Yu Yao, Heng Liang, Xin Fang, Shengnan Zhang, Zikang Xing, Lei Shi, Chunxiang Kuang, Barbara Seliger, Qing Yang
Summary: IDO1, a heme-containing enzyme, plays a crucial role in the kynurenine pathway of tryptophan metabolism, with implications in immunity and neuronal function. Despite potential applications in cancer and neurodegenerative diseases, cautionary notes from clinical trials indicate a need for better understanding of IDO1 inhibition mechanisms.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Haejin Yoon, Jillian L. Shaw, Marcia C. Haigis, Anna Greka
Summary: This article discusses the roles of lipids in metabolism, including signal transduction, structural integrity of cellular membranes, energy metabolism, and introduces the latest research advancements and technical methods in lipid metabolism. The authors specifically analyze the effects of specific lipid species in physiological pathways, providing a framework for understanding newly identified targets for regulating lipid homeostasis.
Article
Multidisciplinary Sciences
Qiutao Xu, Yaping Yue, Biao Liu, Zhengting Chen, Xuan Ma, Jing Wang, Yu Zhao, Dao-Xiu Zhou
Summary: This study reveals the mechanism of local acetyl-CoA production for histone acetylation and its link to cell division in rice. The interaction between HAT1 and ACLA2 promotes histone lysine acetylation in specific genomic regions, contributing to gene expression and endosperm cell division.
NATURE COMMUNICATIONS
(2023)
Article
Thermodynamics
Ece Polat, Mahmut Altinbas
Summary: Mutagenesis using EMS and tralkoxydim treatment resulted in mutant microalgae strains with enhanced biofuel properties, including higher lipid content and improved biodiesel fuel properties compared to the wild type strain.
INTERNATIONAL JOURNAL OF GREEN ENERGY
(2023)
Article
Multidisciplinary Sciences
Qiang Chen, Jianlong Du, Kun Cui, Wei Fang, Zengqi Zhao, Qiuchi Chen, Kangsen Mai, Qinghui Ai
Summary: Acetylation plays a key role in regulating inflammation induced by lipid surplus, with studies showing that high-fat diet can enhance mitochondrial fatty acid beta-oxidation and increase acetyl-CoA levels in the liver. Activation of ACLY and CEP leads to heightened p65 acetylation, exacerbating inflammation, while inactivation of SIRT1 further intensifies the inflammatory response.
Review
Biochemistry & Molecular Biology
Leila Sawada, Antonio Carlos Rosario Vallinoto, Igor Brasil-Costa
Summary: EBV is an oncovirus associated with various types of cancer, with the reason for cancer development in only some infected individuals still unknown. EBV-associated cancers are more aggressive and resistant to treatment compared to EBV-negative cancers, making monoclonal antibodies targeting immune checkpoints a potential therapy.
Review
Chemistry, Medicinal
Rahul Singh, Deepak B. Salunke
Summary: IDO1 enzyme catalyzes the initial step of kynurenine pathway and is implicated in immune modulation, antioxidation, and cancer progression. Overexpression of IDO1 plays a pivotal role in immune evasion and cancer development. Research and development of IDO1 inhibitors holds significant potential in immunotherapy and disease treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Monica Dominguez, Verena Truemper, Ana Carolina Mota, Bernhard Bruene, Dmitry Namgaladze
Summary: ATP-citrate lyase (ACLY) is a key enzyme involved in metabolic and epigenetic gene regulation. This study investigated the impact of ACLY phosphorylation on its function in human myeloid cells and found that phosphorylation at serine 455 does not affect the enzymatic activity of ACLY. Additionally, loss of ACLY activity may trigger long-term adaptive mechanisms that increase inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sanne G. S. Verberk, Hendrik J. P. van der Zande, Jeroen Baardman, Kyra E. de Goede, Karl J. Harber, Eelco D. Keuning, Joost M. Lambooij, Frank Otto, Anna Zawistowska-Deniziak, Helga E. de Vries, Menno P. J. de Winther, Bruno Guigas, Jan Van den Bossche
Summary: Research indicates that despite enhanced inflammatory responses in vitro, deficiency of macrophage Acly does not worsen acute and chronic inflammatory responses in vivo. Myeloid-specific Acly deletion has limited impact on inflammation and overall metabolic homeostasis in inflammatory disorders like multiple sclerosis and obesity.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Panagiotis Georgianos, Theodoros Eleftheriadis, Vassilios Liakopoulos
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Panagiotis I. Georgianos, Vasilios Vaios, Theodoros Eleftheriadis, Evangelos Papachristou, Vassilios Liakopoulos
Summary: Although initially introduced as glucose-lowering medications, it was discovered that the most important treatment effect of SGLT-2 inhibitors is cardiorenal protection. The benefits of SGLT-2 inhibitors on kidney and cardiovascular outcomes in patients with chronic kidney disease (CKD), regardless of the presence or absence of Type 2 diabetes (T2D), have been consistently shown in landmark trials. Additionally, the nonsteroidal MRA finerenone has effectively improved cardiorenal outcomes in a large Phase 3 clinical trial program that included a wide spectrum of CKD patients with T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Vassiliki Michou, Vassilios Liakopoulos, Stefanos Roumeliotis, Athanasios Roumeliotis, Maria Anifanti, Georgios Tsamos, Aikaterini Papagianni, Pantelis Zempekakis, Asterios Deligiannis, Evangelia Kouidi
Summary: This study aimed to investigate the effects of a home-based exercise training program on Cardiac Autonomic Neuropathy (CAN) and metabolic profile in Diabetic Kidney Disease (DKD) patients undergoing maintenance hemodialysis (HD). The results showed that after a 6-month home-based exercise training program, the EX group had significant improvements in HDL, VO(2)peak, SDNN, pNN50, TS index, HbA1c, and LF. Linear regression analysis showed that VO(2)peak was positively correlated with SDNN and HF. Multiple regression analysis indicated that the improvement of sympathovagal balance and aerobic capacity depended on patients' participation in exercise training.
Article
Sport Sciences
Vasiliki Michou, Michaela Davioti, Niki Syrakou, Vasilios Liakopoulos, Asterios Deligiannis, Evangelia Kouidi
Summary: This study aimed to investigate the effects of a 4-month intradialytic exercise program on the functional capacity and body composition of kidney transplant candidates. The results showed that the exercise program improved grip strength and walking distance, increased muscle mass and body water, and reduced body fat. This is important for improving the quality of life of patients and the success rate of kidney transplant surgery.
JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Christina Poulianiti, Maria Anna Polyzou Konsta, Vassilios Liakopoulos, Ioannis Stefanidis
Summary: This study evaluated the response of renal proximal tubular epithelial cells (RPTECs) to high albumin concentration, focusing on the unfolded protein response (UPR) and DNA damage response (DDR). The results showed that albumin led to reactive oxygen species (ROS) overproduction and protein modification, which activated both UPR and DDR. This resulted in cellular apoptosis, senescence, and epithelial-to-mesenchymal transition (EMT). While agents against endoplasmic reticulum stress (ERS) only partially alleviated the harmful effects, inhibiting ROS upregulation prevented both UPR and DDR. Therefore, suppressing ROS overproduction may be more effective in mitigating the deleterious effects of albumin overload.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Vasiliki Karava, Antonia Kondou, John Dotis, Athanasios Christoforidis, Anna Taparkou, Evangelia Farmaki, Konstantinos Kollios, Vassilios Liakopoulos, Nikoleta Printza
Summary: This study found that in pediatric CKD, adiponectin is associated with muscle wasting, leptin with adiposity, and resistin with systemic inflammation. Adiponectin and cytokine IL-6 may serve as biomarkers for PEW.
JOURNAL OF RENAL NUTRITION
(2023)
Editorial Material
Medicine, General & Internal
Panagiotis I. Georgianos, Vasilis Vaios, Vassilios Liakopoulos
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Transplantation
Francesco Gaetano Casino, Maria Fernanda Slon Roblero, Silvia Gonzalez-Sanchidrian, Sandra Gallego Dominguez, Ignacio Lorenzo Ferris, Valerie A. Luyckx, Vassilios Liakopoulos, Sandip Mitra, Javier Deira Lorenzo, Carlo Basile
Summary: The aim of this study was to obtain a new formula for stdKt/V that defines the minimum required values of eKt/V and TF to achieve the targeted stdKtV in home haemodialysis. The results showed that the formula is reliable and can support clinicians in prescribing the dialysis dose and treatment frequency for patients undergoing HHD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Medicine, General & Internal
Andrew Xanthopoulos, Adamantia Papamichail, Alexandros Briasoulis, Konstantinos Loritis, Angeliki Bourazana, Dimitrios E. Magouliotis, Pantelis Sarafidis, Ioannis Stefanidis, John Skoularigis, Filippos Triposkiadis
Summary: The function of the kidney is closely linked to the function of the heart. Dysfunction/disease of the kidney may initiate or worsen cardiac dysfunction/disease, and vice versa. Chronic kidney disease can affect cardiac function through altered hemodynamics and salt and water retention, leading to heart failure. However, the management of heart failure in the context of kidney disease is challenging due to complex interactions and effects on medication metabolism.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ioanna Chronopoulou, Maria Tziastoudi, Georgios Pissas, Efthimios Dardiotis, Maria Dardioti, Spyridon Golfinopoulos, Georgios Filippidis, Peter R. Mertens, Evangelia E. Tsironi, Vassilios Liakopoulos, Theodoros Eleftheriadis, Ioannis Stefanidis, Gian Marco Ghiggeri
Summary: The study examined the association between polymorphisms of the interleukin-1 gene cluster and the risk of progressive IgAN. A meta-analysis of genetic association studies was conducted to further investigate the involvement of interleukin genes in IgAN. The results suggest that genetic variants and haplotypes in the IL1B, IL1RN, and IL10 genes may contribute to an increased risk for the development and progression of IgAN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Urology & Nephrology
Ariti Tsinari, Stefanos Roumeliotis, Garyfallia Varouktsi, Panagiotis Georgianos, Vasilios Vaios, Vassilios Liakopoulos
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Peripheral Vascular Disease
Christodoula Kourtidou, Panagiotis I. Georgianos, Vasilios Vaios, Vassilios Liakopoulos
JOURNAL OF HUMAN HYPERTENSION
(2023)