NDST3 deacetylates α‐tubulin and suppresses V‐ATPase assembly and lysosomal acidification

C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly

(2021) Tao Wang et al.   Cell Metabolism

Mitochondrial translation deficiency impairs NAD + ‐mediated lysosomal acidification

(2021) Mikako Yagi et al.   EMBO JOURNAL

C9orf72 associates with inactive Rag GTPases and regulates mTORC1‐mediated autophagosomal and lysosomal biogenesis

(2020) Mingmei Wang et al.   AGING CELL

Old factors, new players: transcriptional regulation of autophagy

(2020) Wen-Jie Shu et al.   Autophagy

A reference library for assigning protein subcellular localizations by image-based machine learning

(2020) Wiebke Schormann et al.   JOURNAL OF CELL BIOLOGY

Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

(2020) Ross A. Weber et al.   MOLECULAR CELL

The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases

(2020) Ralph A. Nixon   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structure of V-ATPase from the mammalian brain

(2020) Yazan M. Abbas et al.   SCIENCE

C9orf72/ALFA-1 controls TFEB/HLH-30-dependent metabolism through dynamic regulation of Rag GTPases

(2020) Yon Ju Ji et al.   PLoS Genetics

Effects of α-tubulin acetylation on microtubule structure and stability

(2019) Lisa Eshun-Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition

(2019) Clive Yik-Sham Chung et al.   Nature Chemical Biology

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

(2019) King Faisal Yambire et al.   eLife

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases

(2018) Chao Wang et al.   CURRENT OPINION IN NEUROBIOLOGY

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

(2018) Yingxiao Shi et al.   NATURE MEDICINE

Autophagy as a common pathway in amyotrophic lateral sclerosis

(2018) Dao K.H. Nguyen et al.   NEUROSCIENCE LETTERS

STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH

(2018) Bin Liu et al.   CELL RESEARCH

Cellular Proteostasis in Neurodegeneration

(2018) Alberim Kurtishi et al.   MOLECULAR NEUROBIOLOGY

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system

(2017) Yohei Katoh et al.   MOLECULAR BIOLOGY OF THE CELL

Tubulin acetylation protects long-lived microtubules against mechanical ageing

(2017) Didier Portran et al.   NATURE CELL BIOLOGY

Toxic PRnpoly-dipeptides encoded by theC9orf72repeat expansion block nuclear import and export

(2017) Kevin Y. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubules acquire resistance from mechanical breakage through intralumenal acetylation

(2017) Zhenjie Xu et al.   SCIENCE

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

(2017) Anna L Miles et al.   eLife

Lysosomal cathepsins and their regulation in aging and neurodegeneration

(2016) Veronika Stoka et al.   AGEING RESEARCH REVIEWS

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death

(2016) Chantal Sellier et al.   EMBO JOURNAL

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons

(2016) Rajeeve Sivadasan et al.   NATURE NEUROSCIENCE

C9orf72 is required for proper macrophage and microglial function in mice

(2016) J. G. ORourke et al.   SCIENCE

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling

(2016) Janet Ugolino et al.   PLoS Genetics

A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese

(2016) C Zhang et al.   Translational Psychiatry

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy

(2016) M. Yang et al.   Science Advances

The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway

(2016) Peter M. Sullivan et al.   Acta Neuropathologica Communications

Targeting the lysosome in cancer

(2015) Shengfu Piao et al.   Annals of the New York Academy of Sciences

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

(2015) Caroline Mauvezin et al.   Nature Communications

Assessment of copy number variations in the brain genome of schizophrenia patients

(2015) Miwako Sakai et al.   Molecular Cytogenetics

Autophagy and Its Normal and Pathogenic States in the Brain

(2014) Ai Yamamoto et al.   Annual Review of Neuroscience

Reversible disassembly of the yeast V-ATPase revisited underin vivoconditions

(2014) Katharina Tabke et al.   BIOCHEMICAL JOURNAL

Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: Evidence for a role in retinal degenerations

(2014) Sonia Guha et al.   EXPERIMENTAL EYE RESEARCH

The vacuolar-type H+-ATPase at a glance - more than a proton pump

(2014) M. E. Maxson et al.   JOURNAL OF CELL SCIENCE

C9orf72 nucleotide repeat structures initiate molecular cascades of disease

(2014) Aaron R. Haeusler et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Reduced C9orf72 protein levels in frontal cortex of amyotrophic lateral sclerosis and frontotemporal degeneration brain with the C9ORF72 hexanucleotide repeat expansion

(2014) Adrian J. Waite et al.   NEUROBIOLOGY OF AGING

Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death

(2014) Xinmei Wen et al.   NEURON

rs11098403 polymorphism near NDST3 is associated with a reduced risk of schizophrenia in a Han Chinese population

(2014) Li-Ze Gu et al.   NEUROSCIENCE LETTERS

Regulation of Luminal Acidification by the V-ATPase

(2013) Sylvie Breton et al.   PHYSIOLOGY

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder

(2013) Todd Lencz et al.   Nature Communications

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction

(2012) Frances M. Platt et al.   JOURNAL OF CELL BIOLOGY

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

(2012) B. Dehay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

The Granular Chloride Channel ClC-3 Is Permissive for Insulin Secretion

(2009) Ludmila V. Deriy et al.   Cell Metabolism

Motor Deficit in a Drosophila Model of Mucolipidosis Type IV due to Defective Clearance of Apoptotic Cells

(2008) Kartik Venkatachalam et al.   CELL

Mitochondrial Ca2+ homeostasis in lysosomal storage diseases

(2008) K KISELYOV et al.   CELL CALCIUM

Altered Heparan Sulfate Structure in Mice with DeletedNDST3Gene Function

(2008) Srinivas R. Pallerla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY