Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis

(2019) Lorena Fernandez-Mosquera et al.   Autophagy

Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

(2019) King Faisal Yambire et al.   eLife

Mitochondrial fission requires DRP1 but not dynamins

(2019) Tiago Branco Fonseca et al.   NATURE

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

De novo mutations of the ATP6V1A gene cause developmental encephalopathy with epilepsy

(2018) Anna Fassio et al.   BRAIN

A C9orf72 ALS/FTD Ortholog Acts in Endolysosomal Degradation and Lysosomal Homeostasis

(2018) Anna Corrionero et al.   CURRENT BIOLOGY

Lysosome trafficking and signaling in health and neurodegenerative diseases

(2018) Pearl P.Y. Lie et al.   NEUROBIOLOGY OF DISEASE

Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity

(2018) Zohreh Farsi et al.   eLife

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

(2018) Christine M. Rostosky et al.   Jove-Journal of Visualized Experiments

Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson’s Disease

(2018) Maria Nguyen et al.   TRENDS IN NEUROSCIENCES

The elemental role of iron in DNA synthesis and repair

(2017) Sergi Puig et al.   Metallomics

A Neuron-Specific Gene Therapy Relieves Motor Deficits in Pompe Disease Mice

(2017) Ni-Chung Lee et al.   MOLECULAR NEUROBIOLOGY

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

(2017) Maria B. Bagh et al.   Nature Communications

Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis

(2017) Lorena Fernández-Mosquera et al.   Scientific Reports

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

(2017) Anna L Miles et al.   eLife

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness

(2016) Christina McGuire et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Erythroid cell mitochondria receive endosomal iron by a “kiss-and-run” mechanism

(2016) Amel Hamdi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity

(2016) Nicholas A. Bright et al.   CURRENT BIOLOGY

Loss of Mitochondrial Function Impairs Lysosomes

(2016) Julie Demers-Lamarche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The lysosome as a command-and-control center for cellular metabolism

(2016) Chun-Yan Lim et al.   JOURNAL OF CELL BIOLOGY

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Amide proton signals as pH indicator for in vivo MRS and MRI of the brain—Responses to hypercapnia and hypothermia

(2016) Takashi Watanabe et al.   NEUROIMAGE

Transcriptome assessment of the Pompe (Gaa−/−) mouse spinal cord indicates widespread neuropathology

(2016) S. M. F. Turner et al.   PHYSIOLOGICAL GENOMICS

The Function of V-ATPases in Cancer

(2016) Laura Stransky et al.   PHYSIOLOGICAL REVIEWS

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System

(2016) John D. Murdoch et al.   Cell Reports

Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways

(2016) Yumei Yan et al.   Scientific Reports

Correcting Neuromuscular Deficits With Gene Therapy in Pompe Disease

(2015) Adrian G. Todd et al.   ANNALS OF NEUROLOGY

Synthesis and structure–activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs

(2015) Jose Garcia-Rodriguez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans

(2015) Alfonso Schiavi et al.   CURRENT BIOLOGY

Aneuploidy-induced cellular stresses limit autophagic degradation

(2015) Stefano Santaguida et al.   GENES & DEVELOPMENT

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Unique features of the transcriptional response to model aneuploidy in human cells

(2014) Milena Dürrbaum et al.   BMC GENOMICS

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease

(2014) Karen E. Murphy et al.   BRAIN

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Mammalian iron–sulphur proteins: novel insights into biogenesis and function

(2014) Tracey A. Rouault   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy

(2014) João M.N. Duarte et al.   NEUROBIOLOGY OF AGING

Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease

(2013) Laura D. Osellame et al.   Cell Metabolism

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS)

(2013) Olena Korvatska et al.   HUMAN MOLECULAR GENETICS

Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Complementary RNA and Protein Profiling Identifies Iron as a Key Regulator of Mitochondrial Biogenesis

(2013) Jarred W. Rensvold et al.   Cell Reports

Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

(2012) Nuno Raimundo et al.   CELL

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

(2012) Adam L. Hughes et al.   NATURE

Myelin mapping in the central nervous system of living mice using contrast-enhanced magnetization transfer MRI

(2012) Takashi Watanabe et al.   NEUROIMAGE

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Defects in mitochondrial DNA replication and human disease

(2011) William C. Copeland   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Recruitment of Endophilin to Clathrin-Coated Pit Necks Is Required for Efficient Vesicle Uncoating after Fission

(2011) Ira Milosevic et al.   NEURON

Revisiting the TCA cycle: signaling to tumor formation

(2011) Nuno Raimundo et al.   TRENDS IN MOLECULAR MEDICINE

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Mitochondrial myopathy induces a starvation-like response

(2010) Henna Tyynismaa et al.   HUMAN MOLECULAR GENETICS

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Inhibition of Iron Uptake Is Responsible for Differential Sensitivity to V-ATPase Inhibitors in Several Cancer Cell Lines

(2010) Sarah Straud et al.   PLoS One

Downregulation of SRF–FOS–JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas

(2009) N Raimundo et al.   ONCOGENE

The Inflammatory Response to Cell Death

(2008) Kenneth L. Rock et al.   Annual Review of Pathology-Mechanisms of Disease

Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism

(2008) T. Lambe et al.   BLOOD

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE