Defining the therapeutic time window for suppressing the inflammatory prostaglandin E2 signaling after status epilepticus

Candidate Drug Targets for Prevention or Modification of Epilepsy

(2015) Nicholas H. Varvel et al.   Annual Review of Pharmacology and Toxicology

Prostaglandin E2 EP2 Receptor Deletion Attenuates Intracerebral Hemorrhage-Induced Brain Injury and Improves Functional Recovery

(2015) Jenna L. Leclerc et al.   ASN Neuro

Antiepileptogenic effects of the selective COX-2 inhibitor etoricoxib, on the development of spontaneous absence seizures in WAG/Rij rats

(2015) Rita Citraro et al.   BRAIN RESEARCH BULLETIN

Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis?

(2015) Annamaria Vezzani   Expert Opinion On Drug Safety

Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application

(2015) Annamaria Vezzani et al.   Expert Review of Neurotherapeutics

Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus

(2015) Jianxiong Jiang et al.   NEUROBIOLOGY OF DISEASE

Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus

(2015) Asheebo Rojas et al.   NEUROPHARMACOLOGY

Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus

(2015) C.C. Trandafir et al.   NEUROSCIENCE

Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application

(2015) Annamaria Vezzani et al.   Expert Review of Neurotherapeutics

Development of second generation EP2 antagonists with high selectivity

(2014) Thota Ganesh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Commentary on Kaushik et al.: Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Novel evidence supporting a role for prostanoid receptors in seizure control

(2014) Carlos Fernando Mello et al.   EXPERIMENTAL NEUROLOGY

Lead Optimization Studies of Cinnamic Amide EP2 Antagonists

(2014) Thota Ganesh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclooxygenase-2 in epilepsy

(2013) Asheebo Rojas et al.   EPILEPSIA

Prostaglandin D2 is crucial for seizure suppression and postictal sleep

(2013) Mahesh K. Kaushik et al.   EXPERIMENTAL NEUROLOGY

Novel frontiers in epilepsy treatments: preventing epileptogenesis by targeting inflammation

(2013) Raimondo D’Ambrosio et al.   Expert Review of Neurotherapeutics

Influence of Aspirin on Pilocarpine-Induced Epilepsy in Mice

(2013) Kyoung Hoon Jeong et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

(2013) Jianxiong Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory pathways of seizure disorders

(2013) Nicola Marchi et al.   TRENDS IN NEUROSCIENCES

Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection

(2013) Jianxiong Jiang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Discovery and Characterization of Carbamothioylacrylamides As EP2 Selective Antagonists

(2013) Thota Ganesh et al.   ACS Medicinal Chemistry Letters

Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats

(2012) Lei Ma et al.   BRAIN RESEARCH

Are you in or out? Leukocyte, ion, and neurotransmitter permeability across the epileptic blood-brain barrier

(2012) Damir Janigro   EPILEPSIA

The role of inflammation in epileptogenesis

(2012) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2

(2012) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostaglandins and chronic inflammation

(2012) Tomohiro Aoki et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Putative Role of Prostaglandin Receptor in Intracerebral Hemorrhage

(2012) Shekher Mohan et al.   Frontiers in Neurology

Prostanoid Receptors

(2011) Takako Hirata et al.   CHEMICAL REVIEWS

Inflammation in epilepsy: Clinical observations

(2011) Eleonora Aronica et al.   EPILEPSIA

Ablation of Cyclooxygenase-2 in Forebrain Neurons is Neuroprotective and Dampens Brain Inflammation after Status Epilepticus

(2011) G. E. Serrano et al.   JOURNAL OF NEUROSCIENCE

Management of refractory status epilepticus in adults: still more questions than answers

(2011) Andrea O Rossetti et al.   LANCET NEUROLOGY

Efficacy of Anti-Inflammatory Therapy in a Model of Acute Seizures and in a Population of Pediatric Drug Resistant Epileptics

(2011) Nicola Marchi et al.   PLoS One

Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy

(2010) Linda Holtman et al.   EPILEPSY RESEARCH

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

(2010) Nadine Polascheck et al.   EXPERIMENTAL NEUROLOGY

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor

(2010) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy

(2009) L. Holtman et al.   EPILEPSY RESEARCH

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Emerging roles of PGE2 receptors in models of neurological disease

(2009) Katrin Andreasson   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Comparisons of the mortality and clinical presentations of status epilepticus in private practice community and university hospital settings in Richmond, Virginia

(2009) Robert J. DeLorenzo et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures

(2008) Mauro Schneider Oliveira et al.   EPILEPSY RESEARCH

Altered hippocampal long-term synaptic plasticity in mice deficient in the PGE2 EP2 receptor

(2008) Hongwei Yang et al.   JOURNAL OF NEUROCHEMISTRY

Antagonism of peripheral inflammation reduces the severity of status epilepticus

(2008) Nicola Marchi et al.   NEUROBIOLOGY OF DISEASE

Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: Possible involvement of adenosinergic mechanism

(2007) Kiran Kumar Akula et al.   EPILEPSY RESEARCH