Article
Biochemistry & Molecular Biology
Yuxiang Li, Fangchao Tong, Lu Liu, Zhongqian Su, Jing Ding, Qiang Wang, Xin Wang
Summary: Mossy fiber sprouting is a characteristic of epilepsy and plays a key role in neural circuit formation. CRMP2, whose phosphorylation state regulates neurite/axon outgrowth, has been reported to change in epilepsy patients and animal models. This study provides direct evidence supporting the role of CRMP2 in mossy fiber sprouting in an animal model of epilepsy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Kai-Ge Ma, Hai-Bo Hu, Jin-Song Zhou, Chao Ji, Qi-Sheng Yan, Si-Ming Peng, Lan-Dong Ren, Bing-Nan Yang, Xin-Li Xiao, Yan-Bing Ma, Feng Wu, Kai-Wei Si, Xiao-Lin Wu, Jian-Xin Liu
Summary: It has been found that Gpc4 plays a crucial role in the development of mossy fiber sprouting in the hippocampus, with the mTOR pathway being essential for Gpc4-regulated MFS. Additionally, suppressing Gpc4 expression after status epilepticus has shown to attenuate spontaneous recurrent seizures, indicating that Gpc4 may be a promising target for antiepileptic studies.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Kyoung Hoon Jeong, Jing Zhu, Soojin Park, Won-Joo Kim
Summary: The role of TRPV6 in epilepsy is unclear. This study found that TRPV6 expression is upregulated in the hippocampus of a pilocarpine-induced status epilepticus model and is related to abnormal MF sprouting (MFS) and the incidence of seizures. In vitro experiments showed that TRPV6 expression can regulate axonal formation in cultured hippocampal neurons. Furthermore, TRPV6 is involved in the regulation of Akt-glycogen synthase kinase-3-beta activity, which is related to axonal outgrowth. Therefore, TRPV6 may regulate the formation of aberrant synaptic circuits during epileptogenesis.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Young-Jin Kang, Sang -Hun Lee, Jeffery A. Boychuk, Corwin R. Butler, J. Anna Juras, Ryan A. Cloyd, Bret N. Smith
Summary: Post-traumatic epilepsy and behavioral comorbidities often occur after traumatic brain injury. The neurogenesis of dentate granule cells after injury may contribute to the synaptic reorganization in epilepsy, but the specific role of neurogenesis at different times relative to the injury is unknown. This study found that the birth date of dentate granule cells is related to increased feedback inhibition in the dentate gyrus, which may contribute to altered excitability after brain injury.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Farnaz Nikbakht, Paria Hashemi, Somayeh Vazifekhah, Javad Fahanik Babaei
Summary: This study aimed to investigate the antiepileptogenic effect of apigenin through inhibiting the mTOR pathway in epilepsy. The results showed that apigenin significantly inhibited neural cell death, spontaneous seizure spikes, aberrant neurogenesis, mTOR hyperactivity, and aberrant mossy fiber sprouting. These findings suggest that apigenin has an antiepileptogenic effect and may be a useful target for inhibiting mTOR hyperactivity in epilepsy.
EXPERIMENTAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Li Zhang, Xiaowen Xu, Liya Ma, Xinxin Wang, Meifang Jin, Lili Li, Hong Ni
Summary: This study explores the effects of zinc water supplementation on autism-like behavior, seizure threshold, and neurogenesis in ASD model mice. The results show that zinc water supplementation for 6 weeks can prevent autism-like behavior, reduce susceptibility to seizures, and increase the proliferation of hippocampal progenitor cells in BTBR mice. However, it has less effect on mossy fiber sprouting and neural progenitor cell differentiation. The findings suggest that zinc water can reduce autism-like behavior in a partially inherited autism model mice by promoting hippocampal neural precursor cell proliferation and reversing hyperexcitability.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Medicine, General & Internal
Ting-Ting Du, Ying-Chuan Chen, Guan-Yu Zhu, De-Feng Liu, Yu-Ye Liu, Tian-Shuo Yuan, Xin Zhang, Jian-Guo Zhang
Summary: ATN-DBS significantly reduces seizure frequency, decreases the number of ectopic granule cells, and reduces MFS scores in the hippocampus through down-regulation of the cAMP/PKA signaling pathway and Akt phosphorylation.
CHINESE MEDICAL JOURNAL
(2021)
Article
Neurosciences
Yuxiang Li, Fangchao Tong, Yiying Zhang, Yiying Cai, Jing Ding, Qiang Wang, Xin Wang
Summary: Programmed neural circuit formation is crucial for normal brain functions. This study revealed a novel role of axon guidance molecule family Sema3F/Npn-2 signaling in mossy fiber sprouting (MFS) and epileptogenesis in adult epilepsy animals. Knockdown of Npn-2 in the dentate gyrus led to increased seizure activity and MFS. Npn-2 signaling was found to modulate MFS through regulating axon outgrowth and collateral formation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Gary W. Mathern, Edward H. Bertram
Summary: This study found that neuronal loss associated with limbic epilepsy precedes the onset of seizures and is not a consequence of recurrent seizures. However, intermittent seizures do cause structural changes in the brain, the functional consequences of which are unclear.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Plant Sciences
Chen Jia, Rui Zhang, Liming Wei, Jiao Xie, Suqin Zhou, Wen Yin, Xi Hua, Nan Xiao, Meile Ma, Haisheng Jiao
Summary: The study found that tanshinone IIA has therapeutic effects on epilepsy and cognitive function by modulating synaptic plasticity.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Neurosciences
Yu Chen, Xiao-Lin Wu, Hai-Bo Hu, Shu-Nan Yang, Zi-Yi Zhang, Guan-Ling Fu, Chu-Tong Zhang, Zi-Meng Li, Feng Wu, Kai-Wei Si, Yan-Bing Ma, Sheng-Feng Ji, Jin-Song Zhou, Xiao-Yong Ren, Xin-Li Xiao, Jian-Xin Liu
Summary: Understanding the mechanisms behind axon guidance is crucial for the study of neural disorders. The sprouting of mossy fibers, a common occurrence in patients with mesial temporal lobe epilepsy, is considered a classic example of circuit plasticity in the adult brain. This study reveals the important role of methyl-CpG-binding protein 2 (MeCP2) in the formation of mossy fiber sprouting and identifies the underlying signaling pathway.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Yubin Wang, Yan Liu, Emad Yahya, Diana Quach, Xiaoning Bi, Michel Baudry
Summary: The study revealed that Calpain-2 plays a critical role in epilepsy development, with its prolonged activation leading to neuropathological changes. A selective Calpain-2 inhibitor could potentially serve as a therapeutic treatment for seizure-induced neuropathology.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Clinical Neurology
Carlos A. Lafourcade, Fraser T. Sparks, Angelique Bordey, Ursula Wyneken, Michael H. Mohammadi
Summary: The hippocampal formation is crucial in the development of temporal lobe epilepsy (TLE), a disease characterized by recurrent, unprovoked epileptic discharges. The hippocampal dentate gyrus (DG) acts as a filter to prevent excessive excitation and is considered critical in the progression of epileptogenesis. Endogenous cannabinoids (endocannabinoids) play a central role in regulating neuronal activity in the DG circuit. This review summarizes recent findings on the role of the DG in controlling hyperexcitability and discusses the potential therapeutic interventions using cannabinoids.
Article
Neurosciences
Dandan Wang, Mei-fang Jin, Lili Li, Yueying Liu, Yuxiao Sun, Hong Ni
Summary: PRG5 gene knockout significantly reduces seizure latency and exacerbates the lowered seizure threshold induced by developmental seizures. Additionally, knocking out the PRG5 gene reduces the amount of mossy fiber sprouting to a certain extent. Furthermore, silencing the PRG5 gene significantly increases zinc ion content in hippocampal neurons, impairs neuronal activity and mitochondrial function, and worsens glutamate-induced oxidative stress damage.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Rie Komori, Taira Matsuo, Aya Yokota-Nakatsuma, Ritsuka Hashimoto, Shizuka Kubo, Chihiro Kozawa, Tomomi Kono, Yasuhiro Ishihara, Kouichi Itoh
Summary: Levetiracetam suppresses neuroinflammation and prevents epilepsy onset by inhibiting the expression of Fosl1, which regulates astrocyte reactivity during epileptogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Fang Yuan, Fang Yang, Jingjing Zhao, Feng Fu, Yi Liu, Changhu Xue, Kangjun Wang, Xiangjun Yuan, Dingan Li, Qiuwu Liu, Wei Zhang, Yi Jia, Jianbo He, Jun Zhou, Xiaocheng Wang, Hua Lv, Kang Huo, Zhuanhui Li, Bei Zhang, Chengkai Wang, Li Li, Hongzeng Li, Wen Jiang
Summary: In patients with acute severe stroke, individualized blood pressure lowering treatment did not significantly reduce the rate of three-month death or dependence. The rates of serious adverse events in the two groups were similar.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Peripheral Vascular Disease
Jingjing Zhao, Fang Yuan, Feng Fu, Yi Liu, Changhu Xue, Kangjun Wang, Xiangjun Yuan, Dingan Li, Qiuwu Liu, Wei Zhang, Yi Jia, Jianbo He, Jun Zhou, Xiaocheng Wang, Hua Lv, Kang Huo, Zhuanhui Li, Bei Zhang, Chengkai Wang, Li Li, Hongzeng Li, Fang Yang, Wen Jiang
Summary: The study found that in the subacute phase of severe stroke, six measurements of BPV were strongly correlated with poor outcomes, including minimum, SD, CV, ARV, SV, and FSV. In contrast, this relationship was less pronounced in the acute phase.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Neurosciences
Chang-geng Song, Xin Kang, Fang Yang, Wan-qing Du, Jia-jia Zhang, Long Liu, Jun-jun Kang, Ning Jia, Hui Yue, Lu-yu Fan, Sheng-xi Wu, Wen Jiang, Fang Gao
Summary: This review delves into the important role of the endocannabinoid system (ECS) in neurodevelopment, particularly its impact on GABAergic interneurons. It also discusses the regulatory effects of the ECS on processes such as the expansion of neural stem/progenitor cells, migration, specification, and maturation of neurons, as well as its potential implications in various neurological and psychiatric disorders such as epilepsy, schizophrenia, major depressive disorder, and autism spectrum disorder.
REVIEWS IN THE NEUROSCIENCES
(2021)
Article
Clinical Neurology
Jingjing Zhao, Fang Yang, Changgeng Song, Li Li, Xiai Yang, Xiaofeng Wang, Liping Yu, Jun Guo, Kangjun Wang, Feng Fu, Wen Jiang
Summary: The GATE-ICH trial aims to investigate the effects of small doses of oral glibenclamide on perihematomal edema and prognosis of patients with ICH. This multicenter randomized controlled trial in China will assess the primary outcome of poor functional outcomes at 90 days post-enrollment.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Yingying Su, Huijin Huang, Mengdi Jiang, Suyue Pan, Li Ding, Le Zhang, Wen Jiang, Xiaorong Zhuang
Summary: The multicenter study compared the efficacy and safety of phenobarbital and valproate for generalized convulsive status epilepticus, with phenobarbital showing a higher rate of SE termination compared to valproate. There were no significant differences in EEG epileptic discharge nontermination rates between the two groups.
Review
Clinical Neurology
Tom J. Moullaali, Xia Wang, Else Charlotte Sandset, Lisa J. Woodhouse, Zhe Kang Law, Hisatomi Arima, Kenneth S. Butcher, John Chalmers, Candice Delcourt, Leon Edwards, Salil Gupta, Wen Jiang, Sebastian Koch, John Potter, Adnan Qureshi, Thompson G. Robinson, Rustam Al-Shahi Salman, Jeffrey L. Saver, Nikola Sprigg, Joanna M. Wardlaw, Craig S. Anderson, Philip M. Bath
Summary: Interventions to lower blood pressure within 7 days of intracerebral hemorrhage onset were effective in reducing bleeding, but did not show overall benefit on functional recovery. The treatment effect varied according to strategy and agent.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Zhang Jingjing, Zhao Jingjing, Hui Bo, Wang Le, Wei Jingya, Wei Dong, Yang Fang, Jiang Wen
Summary: The study found that pretreatment of sulfonylureas in diabetic patients with acute basal ganglia hemorrhage may be associated with lower PHE and relative PHE on admission, but did not show a significant impact on clinical outcomes at discharge.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Yong-Li Jiang, Chang-Geng Song, Hui-Min Zhou, Ban Feng, Jing-Jing Zhao, Yu Liu, Yu-Lin Man, Jing Han, Shui-Bing Liu, Wen Jiang
Summary: Sleep-related hypermotor epilepsy (SHE) is a focal epilepsy syndrome that may be caused by disruption of GABAergic neurotransmission. Rare variants in the GABRG2 gene may contribute to the pathogenesis of SHE. Our study found three rare GABRG2 variants in three unrelated SHE patients and showed that these variants affect GABA-evoked current amplitudes and synaptic clustering and distribution of GABA(A)R.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Jingjing Zhao, Fang Yuan, Changgeng Song, Rong Yin, Mingze Chang, Wei Zhang, Bei Zhang, Liping Yu, Yi Jia, Wiling Ma, Yongbin Song, Chengkai Wang, Chaohui Song, Xinfai Wang, Lei Shang, Fang Yang, Wen Jiang
Summary: In patients with severe stroke, modified full enteral nutrition or hypocaloric enteral nutrition did not significantly reduce the risk of poor outcomes compared with full enteral nutrition over a 90-day period. Hypocaloric enteral nutrition might be associated with increased mortality compared with modified full enteral nutrition. Further studies are needed to investigate the optimal strategy.
Article
Endocrinology & Metabolism
Xin-shang Wang, Yong-li Jiang, Liang Lu, Ban Feng, Xue Ma, Kun Zhang, Shao-yu Guan, Le Yang, Qing-yu Fan, Xiao-chen Zhu, Fan Yang, Jing-yu Qi, Liu-kun Yang, Xu-bo Li, Ming-gao Zhao, Wen Jiang, Zhen Tian, Shui-bing Liu
Summary: Chronic pain, often accompanied by anxiety disorders, is difficult to treat due to the exacerbating relationship between the two conditions. GIP, previously studied in neurodegenerative diseases, was found to have analgesic and anxiolytic effects in the treatment of chronic inflammatory pain and pain-related anxiety, possibly through attenuation of neuroinflammation and inhibition of excitatory transmission in the ACC. GIPR activation may be a promising target for future therapies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Xiaojing Shi, Yuanyuan Wang, Xuan Wang, Xiaogang Kang, Fang Yang, Fang Yuan, Wen Jiang
Summary: This study investigated the long-term outcomes of adult cryptogenic febrile infection-related epilepsy syndrome (FIRES). The results revealed that over one-third of patients died in the hospital, but 55% of survivors regained functional independence. However, most patients developed drug-resistant epilepsy and required long-term use of anti-seizure medications.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Yan Liu, Xiao-Gang Kang, Qiong Gao, Yu Liu, Chang-Geng Song, Xiao-Jing Shi, Jia-Ning Wu, Wen Jiang
Summary: This retrospective study evaluated the long-term survival and functional outcomes of patients with prolonged disorders of consciousness (pDoC) 1-8 years after brain injuries. The presence of sleep spindles was found to be significantly associated with both long-term survival and functional outcomes in pDoC patients.
Article
Medicine, General & Internal
Jingjing Zhao, Changgeng Song, Deshuai Li, Xiai Yang, Liping Yu, Kangjun Wang, Jun Wu, Xiaofeng Wang, Dongsong Li, Bo Zhang, Binyong Li, Jun Guo, Weikui Feng, Feng Fu, Xinrong Gu, Jian Qian, Jialong Li, Xiangjun Yuan, Qiuwu Liu, Jiang Chen, Xiaocheng Wang, Yi Liu, Dong Wei, Ling Wang, Lei Shang, Fang Yang, Wen Jiang
Summary: This study found no evidence that glibenclamide (1.25 mg, 3/day) significantly reduces the proportion of poor outcome at day 90 after intracerebral hemorrhage. Additionally, glibenclamide may result in a higher incidence of hypoglycemia.
Article
Neurosciences
Xuan Wang, Yuan-Yuan Wang, Qiong Gao, Yao-Yao Zhang, Jian Wan, Chang-Geng Song, Jing-Ya Wei, Xiao-Gang Kang, Fang Yang, Wen Jiang
Summary: Age, etiology of CSE, non-convulsive SE, mechanical ventilation, and abnormal albumin level at CSE onset are the predictors used to construct and validate a nomogram for predicting individualized risks of poor functional outcomes in CSE patients. This nomogram is an important modification of the END-IT score.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Changgeng Song, Jingjing Zhao, Jianmin Hao, Dan Mi, Jiajia Zhang, Yingying Liu, Shengxi Wu, Fang Gao, Wen Jiang
Summary: This study found that the neuropeptide fragment NPCT is widely distributed in the brain and is involved in neuronal death by regulating energy status. NPCT can promote ATP production, enhance mitochondrial respiratory chain activity, increase neuronal respiration capacity, and have multiple effects on promoting neuronal growth and inhibiting cell apoptosis. In the RSE model, NPCT's protective effect on hippocampal neurons was confirmed through immunoneutralization experiments.
CELL DEATH DISCOVERY
(2023)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
