Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

Predictors of Outcome in Refractory Status Epilepticus

(2013) Sara E. Hocker et al.   JAMA Neurology

Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage

(2012) Laura Librizzi et al.   ANNALS OF NEUROLOGY

The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy

(2012) S. Shorvon et al.   BRAIN

Reduction in delayed mortality and subtle improvement in retrograde memory performance in pilocarpine-treated mice with conditional neuronal deletion of cyclooxygenase-2 gene

(2012) Jamie R. Levin et al.   EPILEPSIA

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2

(2012) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beta adrenergic blockade prevents cardiac dysfunction following status epilepticus in rats

(2011) Jason G. Little et al.   EPILEPSY RESEARCH

Ablation of Cyclooxygenase-2 in Forebrain Neurons is Neuroprotective and Dampens Brain Inflammation after Status Epilepticus

(2011) G. E. Serrano et al.   JOURNAL OF NEUROSCIENCE

Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

(2011) M. Zattoni et al.   JOURNAL OF NEUROSCIENCE

Management of refractory status epilepticus in adults: still more questions than answers

(2011) Andrea O Rossetti et al.   LANCET NEUROLOGY

Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga

(2010) Tilo Grosser et al.   Annual Review of Medicine

Prostanoid EP1 receptor antagonist reduces blood–brain barrier leakage after cerebral ischemia

(2010) Ken-ichi Fukumoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

(2010) Nadine Polascheck et al.   EXPERIMENTAL NEUROLOGY

A novel role of prostaglandin E2 in neuropathic pain

(2010) Shunji Kunori et al.   GLIA

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor

(2010) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats

(2009) Cameron S. Metcalf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy

(2009) L. Holtman et al.   EPILEPSY RESEARCH

Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor

(2009) A. Savonenko et al.   EXPERIMENTAL NEUROLOGY

Interleukin-6 Induces Prostaglandin E2 Synthesis in Mouse Astrocytes

(2009) Toshiyuki Chikuma et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Targeting Prostaglandin E2 EP1 Receptors Prevents Seizure-Associated P-glycoprotein Up-Regulation

(2009) A. Pekcec et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Emerging roles of PGE2 receptors in models of neurological disease

(2009) Katrin Andreasson   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Comparisons of the mortality and clinical presentations of status epilepticus in private practice community and university hospital settings in Richmond, Virginia

(2009) Robert J. DeLorenzo et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

The prostaglandin E2EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis

(2008) Xibin Liang et al.   ANNALS OF NEUROLOGY

Status epilepticus produces chronic alterations in cardiac sympathovagal balance

(2008) Cameron S. Metcalf et al.   EPILEPSIA

Altered hippocampal long-term synaptic plasticity in mice deficient in the PGE2 EP2 receptor

(2008) Hongwei Yang et al.   JOURNAL OF NEUROCHEMISTRY

Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity

(2007) Peter Thornton et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The role of inflammation in CNS injury and disease

(2006) Sian-Marie Lucas et al.   BRITISH JOURNAL OF PHARMACOLOGY