New developments in flavivirus drug discovery

Nucleoside Inhibitors of Tick-Borne Encephalitis Virus

(2015) Luděk Eyer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection

(2015) Jacob Nelson et al.   ANTIVIRAL RESEARCH

Targeting dengue virus NS4B protein for drug discovery

(2015) Xuping Xie et al.   ANTIVIRAL RESEARCH

Animal models for studying dengue pathogenesis and therapy

(2015) Kitti Wing Ki Chan et al.   ANTIVIRAL RESEARCH

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids

(2015) Yan Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Dual inhibitors of the dengue and West Nile virus NS2B–NS3 proteases: Synthesis, biological evaluation and docking studies of novel peptide-hybrids

(2015) Allan Bastos Lima et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, optimization and antiviral activity of a class of hybrid dengue virus E protein inhibitors

(2015) Surender Singh Jadav et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope

(2015) Luke N. Robinson et al.   CELL

Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue

(2015) Mira A. M. Behnam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors

(2015) Lena F. Weigel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Dengue Virus NS4B Inhibitors

(2015) Qing-Yin Wang et al.   JOURNAL OF VIROLOGY

Synthesis and assessment of 4-aminotetrahydroquinazoline derivatives as tick-borne encephalitis virus reproduction inhibitors

(2015) Kseniya N. Sedenkova et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Molecular basis for specific viral RNA recognition and 2′-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

(2015) Yongqian Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention

(2015) Joanna Zmurko et al.   REVIEWS IN MEDICAL VIROLOGY

Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers

(2015) G. Fibriansah et al.   SCIENCE

Development of the Sanofi Pasteur tetravalent dengue vaccine: One more step forward

(2015) Bruno Guy et al.   VACCINE

Mouse models of dengue virus infection for vaccine testing

(2015) Vanessa V. Sarathy et al.   VACCINE

A small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture

(2015) Rajendra Raut et al.   Virology Journal

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

(2015) Yongqian Zhao et al.   PLoS Pathogens

Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase

(2015) Noreena L. Sweeney et al.   ACS Infectious Diseases

Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase

(2015) Matthew Brecher et al.   ACS Infectious Diseases

Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine

(2014) Christian G. Noble et al.   ANTIVIRAL RESEARCH

Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery

(2014) Bruno Coutard et al.   ANTIVIRAL RESEARCH

Peptide inhibitor of Japanese encephalitis virus infection targeting envelope protein domain III

(2014) Xiangyang Zu et al.   ANTIVIRAL RESEARCH

Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format

(2014) Chandrakala Basavannacharya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In search of Flavivirus inhibitors part 2: Tritylated, diphenylmethylated and other alkylated nucleoside analogues

(2014) Milind Saudi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Perturbation in the Conserved Methyltransferase-Polymerase Interface of Flavivirus NS5 Differentially Affects Polymerase Initiation and Elongation

(2014) Jiqin Wu et al.   JOURNAL OF VIROLOGY

Interaction of Flaviviruses with Reproduction Inhibitors Binding in β-OG Pocket: Insights from Molecular Dynamics Simulations

(2014) Evgenia V. Dueva et al.   Molecular Informatics

Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase

(2014) Matthew B. Brecher et al.   PROTEIN SCIENCE

Changes in antiviral susceptibility to entry inhibitors and endocytic uptake of dengue-2 virus serially passaged in Vero or C6/36 cells

(2014) Eliana G. Acosta et al.   VIRUS RESEARCH

Targeting Host Factors to Treat West Nile and Dengue Viral Infections

(2014) Manoj Krishnan et al.   Viruses-Basel

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

(2014) Xiao-Dan Li et al.   PLoS Neglected Tropical Diseases

Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus

(2013) Muslum Yildiz et al.   ACS Chemical Biology

Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase

(2013) Chelsea M. Byrd et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibody-dependent enhancement of dengue virus infection is inhibited by SA-17, a doxorubicin derivative

(2013) Nilda V. Ayala-Nuñez et al.   ANTIVIRAL RESEARCH

Development of specific dengue virus 2′-O- and N7-methyltransferase assays for antiviral drug screening

(2013) K. Barral et al.   ANTIVIRAL RESEARCH

3′,5′Di-O-trityluridine inhibits in vitro flavivirus replication

(2013) Tine De Burghgraeve et al.   ANTIVIRAL RESEARCH

Ten years of dengue drug discovery: Progress and prospects

(2013) Siew Pheng Lim et al.   ANTIVIRAL RESEARCH

Design and evaluation of substrate-based octapeptide and non substrate-based tetrapeptide inhibitors of dengue virus NS2B–NS3 proteases

(2013) Peteris Prusis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis and in vitro Evaluation of West Nile Virus Protease Inhibitors Based on the 2-{6-[2-(5-Phenyl-4H-{1,2,4]triazol-3-ylsulfanyl)acetylamino]benzothiazol-2-ylsulfanyl}acetamide Scaffold

(2013) Sanjay Samanta et al.   ChemMedChem

Development and Characterization of New Peptidomimetic Inhibitors of the West Nile Virus NS2B-NS3 Protease

(2013) M. Zouhir Hammamy et al.   ChemMedChem

In search of flavivirus inhibitors: Evaluation of different tritylated nucleoside analogues

(2013) Grégory Chatelain et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antiviral Resistance and the Future Landscape of Hepatitis C Virus Infection Therapy

(2013) David L. Wyles   JOURNAL OF INFECTIOUS DISEASES

Membrane Topology and Function of Dengue Virus NS2A Protein

(2013) X. Xie et al.   JOURNAL OF VIROLOGY

Rational Design of a Flavivirus Vaccine by Abolishing Viral RNA 2'-O Methylation

(2013) S.-H. Li et al.   JOURNAL OF VIROLOGY

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

Sulfated Escherichia coli K5 Polysaccharide Derivatives Inhibit Dengue Virus Infection of Human Microvascular Endothelial Cells by Interacting with the Viral Envelope Protein E Domain III

(2013) Peter Vervaeke et al.   PLoS One

Exploiting Herpes Simplex Virus Entry for Novel Therapeutics

(2013) Satvik Hadigal et al.   Viruses-Basel

Yellow fever vaccine

(2013) Ramesh Verma et al.   Human Vaccines & Immunotherapeutics

Japanese encephalitis

(2013) Sang-Im Yun et al.   Human Vaccines & Immunotherapeutics

Sulfated Polysaccharide, Curdlan Sulfate, Efficiently Prevents Entry/Fusion and Restricts Antibody-Dependent Enhancement of Dengue Virus Infection In Vitro: A Possible Candidate for Clinical Application

(2013) Koji Ichiyama et al.   PLoS Neglected Tropical Diseases

Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques

(2013) Roland Züst et al.   PLoS Pathogens

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease

(2012) Christoph Nitsche et al.   ANTIVIRAL RESEARCH

Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides

(2012) Carlos A. Pujol et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug

(2012) E. Mastrangelo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Randomized, Double-Blind Placebo Controlled Trial of Balapiravir, a Polymerase Inhibitor, in Adult Dengue Patients

(2012) Nguyet Minh Nguyen, Chau Nguyen Bich Tran, Lam Khanh Phung, Kien Thi Hue Duong, Huy le Anh Huynh, Jeremy Farrar, Quyen Than Ha Nguyen, Hien Tinh Tran, Chau Van Vinh Nguyen, Laura Merson, Long Truong Hoang, Martin L. Hibberd, Pauline P. K. Aw, Andreas Wilm, Niranjan Nagarajan, Dung Thi Nguyen et al.   JOURNAL OF INFECTIOUS DISEASES

Critical Effect of Peptide Cyclization on the Potency of Peptide Inhibitors against Dengue Virus NS2B-NS3 Protease

(2012) Shaoqiong Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Analogue of the Antibiotic Teicoplanin Prevents Flavivirus Entry In Vitro

(2012) Tine De Burghgraeve et al.   PLoS One

Release of Dengue Virus Genome Induced by a Peptide Inhibitor

(2012) Shee-Mei Lok et al.   PLoS One

Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions

(2012) R. de Alwis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flaviviruses and flavivirus vaccines

(2012) Franz X. Heinz et al.   VACCINE

Small-Molecule Inhibitors of Dengue-Virus Entry

(2012) Aaron G. Schmidt et al.   PLoS Pathogens

Tripeptide inhibitors of dengue and West Nile virus NS2B–NS3 protease

(2011) Andreas Schüller et al.   ANTIVIRAL RESEARCH

Use of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors

(2011) Suzanne M. Tomlinson et al.   ANTIVIRAL RESEARCH

Inhibition of Dengue Virus by an Ester Prodrug of an Adenosine Analog

(2010) Y.-L. Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of host cell factors in flavivirus infection: Implications for pathogenesis and development of antiviral drugs

(2010) Boris Pastorino et al.   ANTIVIRAL RESEARCH

Dengue virus life cycle: viral and host factors modulating infectivity

(2010) Izabela A. Rodenhuis-Zybert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Update on New Antivirals Under Development for the Treatment of Double-Stranded DNA Virus Infections

(2010) L K Dropulic et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus

(2010) Tanya Parkinson et al.   Future Medicinal Chemistry

Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase

(2010) Hongping Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

(2010) Siew Pheng Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genotype-Specific Neutralization and Protection by Antibodies against Dengue Virus Type 3

(2010) James D. Brien et al.   JOURNAL OF VIROLOGY

Biochemical and genetic characterization of dengue virus methyltransferase

(2010) Hongping Dong et al.   VIROLOGY

Structural Optimization and De Novo Design of Dengue Virus Entry Inhibitory Peptides

(2010) Joshua M. Costin et al.   PLoS Neglected Tropical Diseases

HIV gp41 Engages gC1qR on CD4+ T Cells to Induce the Expression of an NK Ligand through the PIP3/H2O2 Pathway

(2010) Hugues Fausther-Bovendo et al.   PLoS Pathogens

Structure and functionality in flavivirus NS-proteins: Perspectives for drug design

(2009) Michela Bollati et al.   ANTIVIRAL RESEARCH

Molecular basis of human immunodeficiency virus drug resistance: An update

(2009) Luis Menéndez-Arias   ANTIVIRAL RESEARCH

An adenosine nucleoside inhibitor of dengue virus

(2009) Z. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A scintillation proximity assay for dengue virus NS5 2′-O-methyltransferase—kinetic and inhibition analyses

(2008) S LIM et al.   ANTIVIRAL RESEARCH

Towards the design of antiviral inhibitors against flaviviruses: The case for the multifunctional NS3 protein from Dengue virus as a target

(2008) J LESCAR et al.   ANTIVIRAL RESEARCH

Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein

(2008) Dahai Luo et al.   EMBO JOURNAL

Advances in vaccination against tick-borne encephalitis

(2008) Pamela Rendi-Wagner   Expert Review of Vaccines

Identification of specific histidines as pH sensors in flavivirus membrane fusion

(2008) Richard Fritz et al.   JOURNAL OF CELL BIOLOGY

Potent Cationic Inhibitors of West Nile Virus NS2B/NS3 Protease With Serum Stability, Cell Permeability and Antiviral Activity

(2008) Martin J. Stoermer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells

(2008) Hilde M. van der Schaar et al.   PLoS Pathogens