Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance

Evaluation of amphiphilic aminoglycoside–peptide triazole conjugates as antibacterial agents

(2010) Smritilekha Bera et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of novel antibacterials

(2010) J Richard Miller et al.   Expert Opinion on Drug Discovery

Multidrug-Resistant Gram-Negative Infections

(2009) Helen Giamarellou et al.   DRUGS

Promise and challenges in drug discovery and development of hybrid anticancer drugs

(2009) Lalji K Gediya et al.   Expert Opinion on Drug Discovery

Novel heterodimer antibiotics: a review of recent patent literature

(2009) Daniel D Long et al.   Future Medicinal Chemistry

A Multivalent Approach to Drug Discovery for Novel Antibiotics

(2009) Daniel D Long et al.   JOURNAL OF ANTIBIOTICS

Exploring the Positional Attachment of Glycopeptide/β-lactam Heterodimers

(2009) Daniel D Long et al.   JOURNAL OF ANTIBIOTICS

Design, Synthesis, and Evaluation of Novel Fluoroquinolone−Aminoglycoside Hybrid Antibiotics

(2009) Varvara Pokrovskaya et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug interactions and the evolution of antibiotic resistance

(2009) Pamela J. Yeh et al.   NATURE REVIEWS MICROBIOLOGY

Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge

(2009) Cesar A. Arias et al.   NEW ENGLAND JOURNAL OF MEDICINE

In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Microbiology Profiling Studies with Staphylococci and Streptococci

(2008) G. T. Robertson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Studies of the Mode of Action in Staphylococcus aureus

(2008) G. T. Robertson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Vancomycin−Nisin(1−12) Hybrid Restores Activity against Vancomycin Resistant Enterococci†

(2008) Christopher J. Arnusch et al.   BIOCHEMISTRY

How many modes of action should an antibiotic have?

(2008) H BROTZOESTERHELT et al.   CURRENT OPINION IN PHARMACOLOGY

Synthesis and antimalarial evaluation of novel pyridine quinoline hybrids

(2008) Badri Narayan Acharya et al.   MEDICINAL CHEMISTRY RESEARCH

Accelerated evolution of resistance in multidrug environments

(2008) M. Hegreness et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug interactions modulate the potential for evolution of resistance

(2008) J.-B. Michel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA