Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing

A Versatile Platform for Generating Engineered Extracellular Vesicles with Defined Therapeutic Properties

(2021) Kevin Dooley et al.   MOLECULAR THERAPY

Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery

(2021) Tin Chanh Pham et al.   Journal of Extracellular Vesicles

Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing

(2021) Li Duan et al.   Frontiers in Genetics

Engineered extracellular vesicles as versatile ribonucleoprotein delivery vehicles for efficient and safe CRISPR genome editing

(2021) Xingang Yao et al.   Journal of Extracellular Vesicles

The effect of immune cell‐derived exosomes in the cardiac tissue repair after myocardial infarction: Molecular mechanisms and pre‐clinical evidence

(2021) Heling Wen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

(2020) Bhagyashree S. Joshi et al.   ACS Nano

Extracellular vesicles as drug delivery systems: Why and how?

(2020) Omnia M. Elsharkasy et al.   ADVANCED DRUG DELIVERY REVIEWS

Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping

(2020) Peter Gee et al.   Nature Communications

Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy

(2020) Yujie Liang et al.   ACS Applied Materials & Interfaces

Exosome-mimetics as an engineered gene-activated matrix induces in-situ vascularized osteogenesis

(2020) Yao Zha et al.   BIOMATERIALS

Extracellular vesicles engineered with valency-controlled DNA nanostructures deliver CRISPR/Cas9 system for gene therapy

(2020) Jialang Zhuang et al.   NUCLEIC ACIDS RESEARCH

Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications

(2020) Xiaojuan Zhang et al.   DEVELOPMENTAL CELL

Next-Generation CRISPR Technologies and Their Applications in Gene and Cell Therapy

(2020) M. Alejandra Zeballos C. et al.   TRENDS IN BIOTECHNOLOGY

Viral Delivery Systems for CRISPR

(2019) Christine Xu et al.   Viruses-Basel

Exosome-Like Nanoparticles: A New Type Of Nanocarrier

(2019) Mário Fernandes et al.   CURRENT MEDICINAL CHEMISTRY

Delivery Aspects of CRISPR/Cas for in Vivo Genome Editing

(2019) Danny Wilbie et al.   ACCOUNTS OF CHEMICAL RESEARCH

CRISPR/Cas system for genome editing: progress and prospects as a therapeutic tool

(2019) Deepak Kumar Sahel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The next generation of CRISPR–Cas technologies and applications

(2019) Adrian Pickar-Oliver et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Friend or Foe? Evidence Indicates Endogenous Exosomes Can Deliver Functional gRNA and Cas9 Protein

(2019) Ran Chen et al.   Small

Activation of Necroptosis by Engineered Self Tumor-Derived Exosomes Loaded with CRISPR/Cas9

(2019) Diana Gulei et al.   Molecular Therapy-Nucleic Acids

Advances in therapeutic application of CRISPR-Cas9

(2019) Jinyu Sun et al.   Briefings in Functional Genomics

Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo

(2019) Nikki Heath et al.   Nanomedicine

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

(2019) Tuying Yong et al.   Nature Communications

Cancer cell-type tropism is one of crucial determinants for the efficient systemic delivery of cancer cell-derived exosomes to tumor tissues

(2019) Sherif E. Emam et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities

(2018) Ling Li et al.   BIOMATERIALS

ARMMs as a versatile platform for intracellular delivery of macromolecules

(2018) Qiyu Wang et al.   Nature Communications

Efficient RNA drug delivery using red blood cell extracellular vesicles

(2018) Waqas Muhammad Usman et al.   Nature Communications

VSV-G-Enveloped Vesicles for Traceless Delivery of CRISPR-Cas9

(2018) Claudia Montagna et al.   Molecular Therapy-Nucleic Acids

Exosome-Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

(2018) Yao Lin et al.   Advanced Science

Gold Nanoparticles in Cancer Treatment

(2018) Krzysztof Sztandera et al.   MOLECULAR PHARMACEUTICS

Gesicle-Mediated Delivery of CRISPR/Cas9 Ribonucleoprotein Complex for Inactivating the HIV Provirus

(2018) Lee A. Campbell et al.   MOLECULAR THERAPY

CRISPR editing in biological and biomedical investigation

(2017) Jiaojiao Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting

(2017) Seung Min Kim et al.   JOURNAL OF CONTROLLED RELEASE

Non-viral and viral delivery systems for CRISPR-Cas9 technology in the biomedical field

(2017) Zhi-Yao He et al.   Science China-Life Sciences

Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

(2015) Tek N. Lamichhane et al.   MOLECULAR PHARMACEUTICS

Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo

(2014) Bence György et al.   BIOMATERIALS

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY