Article
Engineering, Biomedical
Jianwen Hou, Zhaozhao Ding, Xin Zheng, Yixin Shen, Qiang Lu, David L. Kaplan
Summary: Tough porous cryogels with angiogenesis and osteogenesis features remain a design challenge. In this study, deferoxamine (DFO) is loaded in silk nanofiber-derived cryogels to introduce angiogenic capacity. The concentration of silk nanofibers in the system is tuned to control the mechanical cues and the sustained release of DFO, resulting in faster regeneration of vascularized bone tissue.
ADVANCED HEALTHCARE MATERIALS
(2023)
Editorial Material
Biophysics
Qili Sun, Zhanpeng Liu, Chao Xie, Liqiu Hu, Huili Li, Yongmei Ge, Lijun Lin, Bin Tang
Summary: Physical exercise releases BDNF to promote bone formation and healing. Researchers have developed a multifunctional drug system using 7,8-DHF@ZIF-8, which combines ZIF-8's properties with that of 7,8-DHF similar to BDNF. The system showed slow and controlled drug release, enhanced cell proliferation, and improved gene expression related to bone formation and angiogenesis, indicating its potential in facilitating bone defect healing.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Jiankai Li, Tianshuai Zhang, Mingmang Pan, Feng Xue, Fang Lv, Qinfei Ke, He Xu
Summary: Impaired angiogenesis is a major factor in non-healing diabetic wounds. In this study, a nanofiber/hydrogel core-shell scaffold with a three-dimensional multilayer patterned structure was developed to promote diabetic wound healing and improve angiogenesis. The scaffold showed improved porosity and moisture retention, and significantly promoted cell adhesion and angiogenesis. In vivo experiments demonstrated the scaffold's effectiveness in enhancing the healing of diabetic wounds.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Zhihai Fan, Hongxiang Liu, Shilei Shi, Zhaozhao Ding, Zhen Zhang, Qiang Lu, David L. Kaplan
Summary: This study investigated the use of electric field induced aligned nanofiber layers to regulate the release of deferoxamine (DFO) for dynamic control of vascularization in bone regeneration. The results showed that the changeable release of DFO influenced angiogenesis and osteogenesis. Cell studies revealed the regulation of cell responses and cytokine secretion related to vascularization in the scaffolds. In vivo experiments demonstrated that the composite scaffolds with the best osteogenic capacity achieved superior bone regeneration in a rat bone defect model. The findings highlight the importance of dynamically controlling angiogenic properties for improving bone regeneration.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Weiyue Zhang, Lutong Wang, Haoyu Guo, Lulu Chen, Xin Huang
Summary: This study presents a strategy of using bioinspired nanovesicles (NVs) derived from induced pluripotent stem cells (iPSCs)-derived endothelial cells (ECs) as exosome mimetics for targeted delivery of dapagliflozin (DA). These NVs can target ECs and facilitate angiogenesis and diabetic wound healing through the HIF-1α/VEGFA pathway.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Xinghui Wei, Wenhao Zhou, Zhen Tang, Hao Wu, Yichao Liu, Hui Dong, Ning Wang, Hai Huang, Shusen Bao, Lei Shi, Xiaokang Li, Yufeng Zheng, Zheng Guo
Summary: This study enhanced the osseointegration capacity of PEEK materials through porous structural design and activated surface modification. The activated surface promoted cell proliferation, adhesion, osteoblast differentiation, and mineralization. The porous PEEK scaffolds facilitated vascular ingrowth and bone ingrowth, and the released Mg2+ accelerated early bone ingrowth by promoting angiogenesis.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Composites
Boxue Chen, Yi Zhang, Chi Mao, Yu Gan, Bolun Li, Haopeng Cai
Summary: This study fabricated rapid self-healing carbon fiber/epoxy composites by using core-shell nanofiber as a healing agent, which can efficiently fill and completely heal the damaged region.
COMPOSITES SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Weijia Zheng, Zhenzu Bai, Shan Huang, Kai Jiang, Long Liu, Xiaoyan Wang
Summary: Efficient biological scaffolds are needed to promote bone defect healing. This study reports on the preparation of a composite scaffold using coaxial electrospinning. The scaffold has a nano-scale morphology, high porosity, and sufficient mechanical strength to support tissue. Furthermore, the scaffold can sustain the release of nutrients, promoting bone and blood vessel growth, and accelerating bone defect repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xue Feng, Suisui Jiang, Fan Zhang, Runfang Wang, Yuanhui Zhao, Mingyong Zeng
Summary: The study demonstrates that WSMP extracted from oyster shells can promote the proliferation, differentiation, and mineralization of osteoblasts both in vitro and in vivo. This finding suggests a potential application of WSMP in bone regeneration and osteoporosis treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Guoxin Tan, Dandan Liu, Renfang Zhu, Hao Pan, Jiayang Li, Weisan Pan
Summary: This study developed a core-shell nanoplatform for targeted delivery of genes to the retina, showing potential for treating retinal diseases such as AMD. The platform demonstrated safety and efficiency in delivering genes to the retina, inhibiting VEGF expression and angiogenesis. This nanoplatform has the capability to overcome barriers in gene delivery to the retina, offering a promising approach for retinal gene therapy.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Physical
Yuluo Chen, Jinpeng Luo, Hang Xu, Xinran Hou, Man Gong, Changshu Yang, HuiCong Liu, Xiuqin Wei, Lang Zhou, Chuanqiang Yin, Xiaomin Li
Summary: Due to its excellent thermal stability, polyimide (PI) is considered a promising alternative for high-safety lithium-ion batteries (LIBs) separators. However, the wettability of PI separators to electrolytes remains undesirable. In this study, a composite membrane with a core-shell structure was developed using the complexation-hydrolyzation method, where gamma-Al2O3 nanoparticles were anchored on PI nanofibers (PI@gamma-Al2O3) as an LIB separator. The results showed that the PI@gamma-Al2O3 nanofiber membrane exhibited improved physicochemical properties and electrochemical performances, including enhanced wettability and higher ionic conductivity. Moreover, the membrane maintained a high capacity retention rate after 100 cycles. Therefore, the core-shell PI@gamma-Al2O3 nanofiber membranes have a promising future for the safety and stability of LIBs.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Miaomiao Shang, Bingjie Ma, Xueyan Hu, Ling Liu, Jin Wang, Xuan Zhang
Summary: Rapid and portable water purification technologies are increasingly important for travelers in the wild. This study presents a biomimetic nanofiber membrane with dual functions, capable of efficiently removing soluble and insoluble contaminants. The membrane shows excellent purification performance in both laboratory and field tests.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Parisa Khayambashi, Janaki Iyer, Sangeeth Pillai, Akshaya Upadhyay, Yuli Zhang, Simon D. Tran
Summary: Tissue engineering has a long history in regenerative medicine, and methods such as cell-encapsulated hydrogels and exosomes can enhance the regenerative potential of various tissues, with hydrogels being the most user-friendly, economical, and accessible material for encapsulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
Fengchun Liao, Ziqi Liao, Tao Zhang, Weidong Jiang, Peiqi Zhu, Zhenchen Zhao, Henglei Shi, Dan Zhao, Nuo Zhou, Xuanping Huang
Summary: This study reveals that suppressing THBS1 in ECFC-Exos may enhance angiogenesis and bone healing, providing a promising strategy to shorten the duration of DO procedures.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Nanoscience & Nanotechnology
Yuangang Wu, Long Yang, Li Chen, Mengyu Geng, Zhengyi Xing, Siyu Chen, Yi Zeng, Jinhan Zhou, Kaibo Sun, Xiao Yang, Bin Shen
Summary: This study designed and fabricated two porous CaP bioceramic granules with core-shell structures for the first time. The results showed that HA@BCP bioceramic granules could promote bone tissue regeneration in vivo, indicating their promising potential for bone defect repair.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.