Amyloid-β: A double agent in Alzheimer's disease?

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

(2020) David Gate et al.   NATURE

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease

(2020) Amy F. T. Arnsten et al.   Alzheimers & Dementia

Commentary: Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer's Disease

(2019) Janusz K. Rybakowski   Frontiers in Aging Neuroscience

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice

(2019) Giovanna De Chiara et al.   PLoS Pathogens

Aβ oligomers trigger and accelerate Aβ seeding

(2019) Natalie Katzmarski et al.   BRAIN PATHOLOGY

HIV and Alzheimer’s disease: complex interactions of HIV-Tat with amyloid β peptide and Tau protein

(2019) Alina Hategan et al.   JOURNAL OF NEUROVIROLOGY

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

(2019) Bernard J. Hanseeuw et al.   JAMA Neurology

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Reevaluating the Microbial Infection Link to Alzheimer’s Disease

(2019) Lee Schnaider et al.   JOURNAL OF ALZHEIMERS DISEASE

Is Alzheimer’s disease an inflammasomopathy?

(2019) Claudia F. Pereira et al.   AGEING RESEARCH REVIEWS

Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease

(2019) Amy F. T. Arnsten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cognitive symptoms of Alzheimer’s disease: clinical management and prevention

(2019) Elizabeth Joe et al.   BMJ-British Medical Journal

The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology

(2018) Constantinos D. Paspalas et al.   Alzheimers & Dementia

Spreading of Tau Pathology in Sporadic Alzheimer’s Disease Along Cortico-cortical Top-Down Connections

(2018) Heiko Braak et al.   CEREBRAL CORTEX

The Underlying Role of Oxidative Stress in Neurodegeneration: A Mechanistic Review

(2018) Habib Yaribeygi et al.   CNS & Neurological Disorders-Drug Targets

Herpes Zoster and Dementia

(2018) Vincent Chin-Hung Chen et al.   JOURNAL OF CLINICAL PSYCHIATRY

Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions

(2018) Victor L. Villemagne et al.   Nature Reviews Neurology

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

(2018) William A. Eimer et al.   NEURON

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

(2018) Nian-Sheng Tzeng et al.   Neurotherapeutics

Infection of Fungi and Bacteria in Brain Tissue From Elderly Persons and Patients With Alzheimer’s Disease

(2018) Ruth Alonso et al.   Frontiers in Aging Neuroscience

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

The efficacy and safety of memantine for the treatment of Alzheimer’s disease

(2018) Shinji Matsunaga et al.   Expert Opinion On Drug Safety

The antimicrobial protection hypothesis of Alzheimer's disease

(2018) Robert D. Moir et al.   Alzheimers & Dementia

Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer’s Disease

(2018) Ruth F. Itzhaki   Frontiers in Aging Neuroscience

Microglia in Alzheimer's Disease: Risk Factors and Inflammation

(2018) Atsuko Katsumoto et al.   Frontiers in Neurology

Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer’s disease –conformist, nonconformist, and realistic prospects for AD pathogenesis

(2018) Hongmei Li et al.   Translational Neurodegeneration

NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

(2018) Michaela Kerstin Müller et al.   Acta Neuropathologica Communications

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Integrated late onset Alzheimer's disease (LOAD) susceptibility genes: Cholesterol metabolism and trafficking perspectives

(2017) Hee Kim Dong et al.   GENE

Memantine for Alzheimer’s Disease: An Updated Systematic Review and Meta-analysis

(2017) Taro Kishi et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

(2017) Jun Yin et al.   MOLECULAR NEUROBIOLOGY

Early-Onset Alzheimer Disease

(2017) Mario F. Mendez   NEUROLOGIC CLINICS

Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model

(2017) Rui Hu et al.   Cell Death & Disease

Vanillic acid attenuates Aβ1-42-induced oxidative stress and cognitive impairment in mice

(2017) Faiz Ul Amin et al.   Scientific Reports

Alzheimer’s disease, dementia, and stem cell therapy

(2017) Thomas Duncan et al.   Stem Cell Research & Therapy

16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain

(2017) David C. Emery et al.   Frontiers in Aging Neuroscience

Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex

(2017) Jorge Sepulcre et al.   JAMA Neurology

Herpes Simplex Virus Type 1 in Alzheimer's Disease: The Enemy Within

(2017) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic Inflammation and Amyloidogenesis in Alzheimer's Disease -- Role of Spirochetes1

(2017) Judith Miklossy   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease-Specific Tau Phosphorylation is Induced by Herpes Simplex Virus Type 1

(2017) Matthew A. Wozniak et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline

(2017) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

Polymicrobial Infections In Brain Tissue From Alzheimer’s Disease Patients

(2017) Diana Pisa et al.   Scientific Reports

Herpes simplex virus type-1: replication, latency, reactivation and its antiviral targets

(2016) Camilly P Pires de Mello et al.   ANTIVIRAL THERAPY

The Prevalence and Incidence of Dementia Due to Alzheimer’s Disease: a Systematic Review and Meta-Analysis

(2016) Kirsten M. Fiest et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Stem Cell Therapy for Alzheimer’s Disease: A Review of Recent Clinical Trials

(2016) Jae Myeong Kang et al.   JOURNAL OF ALZHEIMERS DISEASE

Bacterial Amyloid and DNA are Important Constituents of Senile Plaques: Further Evidence of the Spirochetal and Biofilm Nature of Senile Plaques

(2016) Judith Miklossy   JOURNAL OF ALZHEIMERS DISEASE

The amyloid cascade hypothesis: are we poised for success or failure?

(2016) Eric Karran et al.   JOURNAL OF NEUROCHEMISTRY

Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity

(2016) Clemens Falker et al.   JOURNAL OF NEUROCHEMISTRY

Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation

(2016) Mahmoud L. Soliman et al.   Journal of Neuroimmune Pharmacology

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

TYROBP genetic variants in early-onset Alzheimer's disease

(2016) Cyril Pottier et al.   NEUROBIOLOGY OF AGING

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Neurobiology of Alzheimer’s Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions

(2015) Joel Raskin et al.   Current Alzheimer Research

Mechanisms of HIV-1 Tat Neurotoxicity via CDK5 Translocation and Hyper-Activation: Role in HIV-Associated Neurocognitive Disorders

(2015) Jerel Fields et al.   CURRENT HIV RESEARCH

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

(2015) Keith A. Vossel et al.   JOURNAL OF CELL BIOLOGY

Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce Aβ1–42 secretion in SH-SY5Y neural cells

(2015) Mahfuz B. Khan et al.   JOURNAL OF NEUROVIROLOGY

Orientin alleviates cognitive deficits and oxidative stress in Aβ1–42-induced mouse model of Alzheimer's disease

(2015) Linjie Yu et al.   LIFE SCIENCES

Herpes simplex virus type 2 infection induces AD-like neurodegeneration markers in human neuroblastoma cells

(2015) Henrike Kristen et al.   NEUROBIOLOGY OF AGING

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Different Brain Regions are Infected with Fungi in Alzheimer’s Disease

(2015) Diana Pisa et al.   Scientific Reports

β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1

(2014) Karine Bourgade et al.   BIOGERONTOLOGY

Heavy metals toxicity: effect of cadmium ions on amyloid beta protein 1–42. Possible implications for Alzheimer’s disease

(2014) Gabriella Notarachille et al.   BIOMETALS

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

Axonal Transport Defects in Alzheimer’s Disease

(2014) Zi-Xuan Wang et al.   MOLECULAR NEUROBIOLOGY

Alzheimer's Associated β-Amyloid Protein Inhibits Influenza A Virus and Modulates Viral Interactions with Phagocytes

(2014) Mitchell R. White et al.   PLoS One

cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

(2014) Becky C. Carlyle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress in Alzheimer’s disease

(2014) Zhichun Chen et al.   Neuroscience Bulletin

Detection of bacterial antigens and Alzheimer’s disease-like pathology in the central nervous system of BALB/c mice following intranasal infection with a laboratory isolate of Chlamydia pneumoniae

(2014) Christopher S. Little et al.   Frontiers in Aging Neuroscience

National Institutes of Health State-of-the-Science Conference Statement: Preventing Alzheimer Disease and Cognitive Decline

(2013) Martha L. Daviglus   ANNALS OF INTERNAL MEDICINE

A review on cholinesterase inhibitors for Alzheimer’s disease

(2013) Preet Anand et al.   ARCHIVES OF PHARMACAL RESEARCH

Intravenous immunoglobulin reduces beta amyloid and abnormal tau formation caused by herpes simplex virus type 1

(2013) Matthew A. Wozniak et al.   JOURNAL OF NEUROIMMUNOLOGY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production

(2013) Xuesong Chen et al.   NEUROBIOLOGY OF AGING

Amyloid-β and APP Deficiencies Cause Severe Cerebrovascular Defects: Important Work for an Old Villain

(2013) Salvadore Luna et al.   PLoS One

Dysregulation of synaptic and extrasynaptic N-methyl-D-aspartate receptors induced by amyloid-β

(2013) Zhi-Cong Wang et al.   Neuroscience Bulletin

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

(2012) Wojciech Danysz et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease

(2012) Misha Zilberter et al.   JOURNAL OF NEUROCHEMISTRY

Antimicrobial activity of peptides derived from human ß-amyloid precursor protein

(2012) Praveen Papareddy et al.   JOURNAL OF PEPTIDE SCIENCE

Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory

(2012) S. Barral et al.   NEUROLOGY

Adiponectin is Protective against Oxidative Stress Induced Cytotoxicity in Amyloid-Beta Neurotoxicity

(2012) Koon-Ho Chan et al.   PLoS One

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

(2011) Rosella Abeti et al.   BRAIN

Genetics of Alzheimer's disease: new evidences for an old hypothesis?

(2011) Jean-Charles Lambert et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Emerging roles of pathogens in Alzheimer disease

(2011) Judith Miklossy   EXPERT REVIEWS IN MOLECULAR MEDICINE

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model

(2010) David E. Hurtado et al.   AMERICAN JOURNAL OF PATHOLOGY

Brain neurotoxic amyloid-beta peptides: their potential role in the pathophysiology of depression and as molecular therapeutic targets

(2010) Nunzio Pomara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease

(2010) Lesley Jones et al.   PLoS One

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

HIV Regulation of Amyloid Beta Production

(2009) Lynn Pulliam   Journal of Neuroimmune Pharmacology

Co-Localization of Amyloid Beta and Tau Pathology in Alzheimer's Disease Synaptosomes

(2008) Jeffrey A. Fein et al.   AMERICAN JOURNAL OF PATHOLOGY

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA