Recent advancements in therapeutic targeting of the Warburg effect in refractory ovarian cancer: A promise towards disease remission
出版年份 2021 全文链接
标题
Recent advancements in therapeutic targeting of the Warburg effect in refractory ovarian cancer: A promise towards disease remission
作者
关键词
Warburg effect, Aerobic glycolysis, Glucose transporters, Hypoxia, Tumor microenvironment, Epithelial ovarian cancer, Chemoresistance, Reverse Warburg effect, Anti-glycolytic therapy
出版物
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1876, Issue 1, Pages 188563
出版商
Elsevier BV
发表日期
2021-05-07
DOI
10.1016/j.bbcan.2021.188563
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Dendritic Cell Vaccines in Ovarian Cancer
- (2021) Xi Zhang et al. Frontiers in Immunology
- Targeting Nrf2 may reverse the drug resistance in ovarian cancer
- (2021) Danjie Li et al. Cancer Cell International
- Wnt5a: A promising therapeutic target in ovarian cancer
- (2021) Weijian Zhou et al. PATHOLOGY RESEARCH AND PRACTICE
- Transcriptomic analysis reveals tumor stage- or grade-dependent expression of miRNAs in serous ovarian cancer
- (2021) Caglar Berkel et al. Human Cell
- Ikarugamycin inhibits pancreatic cancer cell glycolysis by targeting hexokinase 2
- (2020) Shu‐Heng Jiang et al. FASEB JOURNAL
- Metabolic Plasticity in Chemotherapy Resistance
- (2020) Maria Andrea Desbats et al. Frontiers in Oncology
- Ginsenoside 20(S)‐Rg3 upregulates HIF‐1α‐targeting miR‐519a‐5p to inhibit the Warburg effect in ovarian cancer cells
- (2020) Jiaojiao Lu et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells
- (2020) Delu Dong et al. LIFE SCIENCES
- Novel Therapeutic Strategies for Ovarian Cancer Stem Cells
- (2020) Nastassja Terraneo et al. Frontiers in Oncology
- Beyond the Warburg Effect: N-Myc Contributes to Metabolic Reprogramming in Cancer Cells
- (2020) Go J. Yoshida Frontiers in Oncology
- Digging deeper through glucose metabolism and its regulators in cancer and metastasis
- (2020) Majid Ghanavat et al. LIFE SCIENCES
- MAP30 protein from Momordica charantia is therapeutic and has synergic activity with cisplatin against ovarian cancer in vivo by altering metabolism and inducing ferroptosis
- (2020) David W Chan et al. PHARMACOLOGICAL RESEARCH
- A Positive Feedback Loop of lncRNA DSCR8/miR-98-5p/STAT3/HIF-1α Plays a Role in the Progression of Ovarian Cancer
- (2020) Lina Dong et al. Frontiers in Oncology
- Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status
- (2019) Angiolo Gadducci et al. Journal of Ovarian Research
- Dichloroacetic acid upregulates apoptosis of ovarian cancer cells by regulating mitochondrial function
- (2019) Li Zhou et al. OncoTargets and Therapy
- Epithelial ovarian cancer
- (2019) Stephanie Lheureux et al. LANCET
- High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints
- (2019) Michael-Antony Lisio et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Causes, consequences, and therapy of tumors acidosis
- (2019) Smitha R. Pillai et al. CANCER AND METASTASIS REVIEWS
- Novel pharmacological effects of poly (ADP-ribose) polymerase inhibitor rucaparib on the lactate dehydrogenase pathway
- (2019) Yuma Nonomiya et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Follicle-stimulating hormone promoted pyruvate kinase isozyme type M2-induced glycolysis and proliferation of ovarian cancer cells
- (2019) Shuangdi Li et al. ARCHIVES OF GYNECOLOGY AND OBSTETRICS
- HIF inactivation of p53 in Ovarian Cancer Can be Reversed by Topotecan, Restoring Cisplatin and Paclitaxel Sensitivity
- (2019) Basmina Parmakhtiar et al. MOLECULAR CANCER RESEARCH
- Enhanced anti-colon cancer efficacy of 5-fluorouracil by epigallocatechin-3- gallate co-loaded in wheat germ agglutinin-conjugated nanoparticles
- (2019) Ruoning Wang et al. Nanomedicine-Nanotechnology Biology and Medicine
- Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells
- (2019) Lihua Chen et al. CELLULAR ONCOLOGY
- Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades
- (2019) Michelle K. Y. Siu et al. Cancers
- The cytotoxic effect and glucose uptake modulation of Baeckea frutescens on breast cancer cells
- (2019) S. H. Shahruzaman et al. BMC Complementary and Alternative Medicine
- Proton pump inhibitors reduce breast cancer risk in gastric ulcer patients: A population‐based cohort study
- (2019) Dah‐Ching Ding et al. Breast Journal
- Small Molecule Inhibition of Glucose Transporters GLUT 1‐4
- (2019) Herbert Waldmann et al. CHEMBIOCHEM
- 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers
- (2019) Hailing Yang et al. CLINICAL CANCER RESEARCH
- Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis
- (2019) Benjamin L. Woolbright et al. MOLECULAR CANCER THERAPEUTICS
- p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer
- (2019) Chae Young Han et al. MOLECULAR CARCINOGENESIS
- MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis
- (2019) Chaoyang Sun et al. ONCOGENE
- SIK2 promotes reprogramming of glucose metabolism through PI3K/AKT/HIF-1α pathway and Drp1-mediated mitochondrial fission in ovarian cancer
- (2019) Tian Gao et al. CANCER LETTERS
- Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy
- (2019) Ali F. Abdel-Wahab et al. PHARMACOLOGICAL RESEARCH
- 2-Deoxy- d -glucose increases GFAT1 phosphorylation resulting in endoplasmic reticulum-related apoptosis via disruption of protein N -glycosylation in pancreatic cancer cells
- (2018) Kousuke Ishino et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response
- (2018) Ji Hee Ha et al. CANCER RESEARCH
- Ginsenoside 20(S)-Rg3 Inhibits the Warburg Effect Via Modulating DNMT3A/ MiR-532-3p/HK2 Pathway in Ovarian Cancer Cells
- (2018) Yuanyuan Zhou et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Glucose transporters in cancer - from tumor cells to the tumor microenvironment
- (2018) Pierre-Benoit Ancey et al. FEBS Journal
- Scutellaria baicalensis targets the hypoxia-inducible factor-1α and enhances cisplatin efficacy in ovarian cancer
- (2018) Imran Hussain et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Molecular mechanisms of drug resistance in ovarian cancer
- (2018) Leyla Norouzi-Barough et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Chemoresistance in ovarian cancer: exploiting cancer stem cell metabolism
- (2018) Shan-Shan Li et al. Journal of Gynecologic Oncology
- Multiple roles of glyoxalase 1-mediated suppression of methylglyoxal glycation in cancer biology—Involvement in tumour suppression, tumour growth, multidrug resistance and target for chemotherapy
- (2018) Naila Rabbani et al. SEMINARS IN CANCER BIOLOGY
- AEG-1 Contributes to Metastasis in Hypoxia-Related Ovarian Cancer by Modulating the HIF-1alpha/NF-kappaB/VEGF Pathway
- (2018) Xiaoyu Yu et al. Biomed Research International
- Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression
- (2018) Bin Zheng et al. MEDICAL SCIENCE MONITOR
- Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers
- (2018) Susmita Mondal et al. INTERNATIONAL JOURNAL OF CANCER
- Pyruvate dehydrogenase kinase 1 contributes to cisplatin resistance of ovarian cancer through EGFR activation
- (2018) Meng Zhang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3
- (2018) George Karageorgis et al. Nature Chemistry
- Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells
- (2018) Yufei Yang et al. Cancer Medicine
- miR-603 targeted hexokinase-2 to inhibit the malignancy of ovarian cancer cells
- (2018) Jiaojiao Lu et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Mechanisms of Drug Resistance in High-Grade Serous Ovarian Cancer
- (2018) Alison E. Freimund et al. HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
- Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
- (2018) Yangbo Feng et al. Cancer Medicine
- Overexpression of PDK4 is associated with cell proliferation, drug resistance and poor prognosis in ovarian cancer
- (2018) Jinghao Wang et al. Cancer Management and Research
- Drug Resistance Driven by Cancer Stem Cells and Their Niche
- (2017) Marta Prieto-Vila et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cancer cell behaviors mediated by dysregulated pH dynamics at a glance
- (2017) Katharine A. White et al. JOURNAL OF CELL SCIENCE
- GLUT 1 receptor expression and circulating levels of fasting glucose in high grade serous ovarian cancer
- (2017) Laura Pizzuti et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer
- (2017) Tai-Kuang Chao et al. PLoS One
- Physical and biological characteristics of multi drug resistance (MDR): An integral approach considering pH and drug resistance in cancer
- (2017) Ziad Omran et al. SEMINARS IN CANCER BIOLOGY
- Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH
- (2017) Laurent Schwartz et al. SEMINARS IN CANCER BIOLOGY
- Loss of PFKFB4 induces cell death in mitotically arrested ovarian cancer cells
- (2017) Charlotte Taylor et al. Oncotarget
- Dual inhibition of glycolysis and glutaminolysis as a therapeutic strategy in the treatment of ovarian cancer
- (2017) Li Sun et al. Oncotarget
- The reverse Warburg effect is likely to be an Achilles’ heel of cancer that can be exploited for cancer therapy
- (2017) Yaojie Fu et al. Oncotarget
- Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876
- (2016) Holger Siebeneicher et al. ChemMedChem
- High-doses of proton pump inhibitors in refractory gastro-intestinal cancer: A case series and the state of art
- (2016) Rosa Falcone et al. DIGESTIVE AND LIVER DISEASE
- Cancer stem cell metabolism: a potential target for cancer therapy
- (2016) Abhijeet Deshmukh et al. Molecular Cancer
- FOXM1 promotes reprogramming of glucose metabolism in epithelial ovarian cancer cells via activation of GLUT1 and HK2 transcription
- (2016) Yu Wang et al. Oncotarget
- Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts
- (2016) Alessandro Arcucci et al. Biomed Research International
- MicroRNA-29B (mir-29b) regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
- (2015) Yue Teng et al. Oncotarget
- Up-regulation of CD44 in the development of metastasis, recurrence and drug resistance of ovarian cancer
- (2015) Yan Gao et al. Oncotarget
- Metformin limits the adipocyte tumor-promoting effect on ovarian cancer
- (2015) Calvin Tebbe et al. Oncotarget
- A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer
- (2014) Nelma Pértega-Gomes et al. BMC CANCER
- Ciglitazone enhances ovarian cancer cell death via inhibition of glucose transporter-1
- (2014) So Jin Shin et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- The chemistry, physiology and pathology of pH in cancer
- (2014) P. Swietach et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Association of overexpression of hexokinase II with chemoresistance in epithelial ovarian cancer
- (2013) Dong Hoon Suh et al. CLINICAL AND EXPERIMENTAL MEDICINE
- HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
- (2013) Gregg L. Semenza JOURNAL OF CLINICAL INVESTIGATION
- Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients’ bed
- (2013) Stefano Ferrari et al. Journal of Translational Medicine
- Reverse Warburg Effect in a Patient With Aggressive B-Cell Lymphoma: Is Lactic Acidosis a Paraneoplastic Syndrome?
- (2013) Ubaldo E. Martinez-Outschoorn et al. SEMINARS IN ONCOLOGY
- c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/β-catenin–ATP-binding cassette G2 signaling
- (2012) W K Chau et al. ONCOGENE
- The role of hypoxia inducible factor-1alpha in gynecological cancer
- (2010) Laura M.S. Seeber et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells
- (2010) M-Q Gao et al. ONCOGENE
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