The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death

Pancreas Pathology of Latent Autoimmune Diabetes in Adults (LADA) in Patients and in a LADA Rat Model Compared to Type 1 Diabetes Mellitus

(2020) Anne Jörns (A.J.) et al.   DIABETES

Glucose-Stimulated Insulin Secretion Fundamentally Requires H2O2 Signaling by NADPH Oxidase 4

(2020) Lydie Plecitá-Hlavatá et al.   DIABETES

The Emerging Roles of Ferroptosis in Huntington’s Disease

(2019) Yajing Mi et al.   NEUROMOLECULAR MEDICINE

Cell recovery by reversal of ferroptosis

(2019) Ho Man Tang et al.   Biology Open

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

(2019) Tae-Jun Park et al.   Cell Death & Disease

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

(2018) Matilde Maiorino et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis-inducing agents compromise in vitro human islet viability and function

(2018) Antonio Bruni et al.   Cell Death & Disease

The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells

(2018) Mami Sato et al.   Scientific Reports

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells

(2018) Chuanhong Wu et al.   Scientific Reports

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

(2018) Xinbing Sui et al.   Frontiers in Pharmacology

Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center

(2017) Giorgio Cozza et al.   FREE RADICAL BIOLOGY AND MEDICINE

ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity

(2017) Ilir Mehmeti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

BID links ferroptosis to mitochondrial cell death pathways

(2017) Sandra Neitemeier et al.   Redox Biology

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

(2016) Shanmugam Manoharan et al.   Oxidative Medicine and Cellular Longevity

Role of the AMP kinase in cytokine-induced human EndoC-βH1 cell death

(2015) Rikard G. Fred et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Influence of cytokines on Dmt1 iron transporter and ferritin expression in insulin-secreting cells

(2014) S Lortz et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Overexpression of glutathione peroxidase 4 prevents β-cell dysfunction induced by prolonged elevation of lipids in vivo

(2013) Khajag Koulajian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis

(2013) Lindsey E. Padgett et al.   Annals of the New York Academy of Sciences

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2012) D. L. Eizirik et al.   DIABETOLOGIA

Differential effects of proinflammatory cytokines on cell death and ER stress in insulin-secreting INS1E cells and the involvement of nitric oxide

(2011) Stella Kacheva et al.   CYTOKINE

Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria

(2011) Ewa Gurgul-Convey et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status

(2010) Ilir Mehmeti et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genetics, pathogenesis and clinical interventions in type 1 diabetes

(2010) Jeffrey A. Bluestone et al.   NATURE

Short Form Glutathione Peroxidase 4 Is the Essential Isoform Required for Survival and Somatic Mitochondrial Functions

(2009) Hanyu Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes

(2008) Pierre Pirot et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS