Autophagy in metabolism and quality control: opposing, complementary or interlinked functions?

Autophagy in inflammation, infection, and immunometabolism

(2021) Vojo Deretic   IMMUNITY

Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy

(2021) Thaddaeus Mutugi Nthiga et al.   JOURNAL OF CELL BIOLOGY

TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses

(2020) Martina Di Rienzo et al.   CELL DEATH AND DIFFERENTIATION

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

(2020) Asier González et al.   Cell Metabolism

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemical activation of SAT1 corrects diet-induced metabolic syndrome

(2020) Francesca Castoldi et al.   CELL DEATH AND DIFFERENTIATION

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

Autophagosome biogenesis: From membrane growth to closure

(2020) Thomas J. Melia et al.   JOURNAL OF CELL BIOLOGY

MERIT, a cellular system coordinating lysosomal repair, removal and replacement

(2020) Jingyue Jia et al.   Autophagy

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

(2020) Alexander Hooftman et al.   Cell Metabolism

Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins

(2020) Gianluca Figlia et al.   DEVELOPMENTAL CELL

MiT/ TFE factors control ER ‐phagy via transcriptional regulation of FAM 134B

(2020) Laura Cinque et al.   EMBO JOURNAL

Systematic quantitative analysis of ribosome inventory during nutrient stress

(2020) Heeseon An et al.   NATURE

A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome

(2020) Gennaro Napolitano et al.   NATURE

Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens

(2020) Suresh Kumar et al.   NATURE CELL BIOLOGY

Leucine regulates autophagy via acetylation of the mTORC1 component raptor

(2020) Sung Min Son et al.   Nature Communications

Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery

(2020) Carlos M. Guardia et al.   Cell Reports

Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation

(2020) Chan Lee et al.   DEVELOPMENTAL CELL

LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

(2020) Shuhei Nakamura et al.   NATURE CELL BIOLOGY

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

(2020) Shintaro Maeda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hallmarks of Health

(2020) Carlos López-Otín et al.   CELL

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

(2019) Jose Norberto S. Vargas et al.   MOLECULAR CELL

Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation

(2019) Suresh Kumar et al.   DEVELOPMENTAL CELL

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

(2019) Frank Madeo et al.   Cell Metabolism

ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors

(2019) Richard S. Marshall et al.   CELL

Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism

(2019) Vikramjit Lahiri et al.   Cell Metabolism

ATG2 transports lipids to promote autophagosome biogenesis

(2019) Diana P. Valverde et al.   JOURNAL OF CELL BIOLOGY

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

Autophagy-Independent Functions of the Autophagy Machinery

(2019) Lorenzo Galluzzi et al.   CELL

Physiological Stress Response by Selective Autophagy

(2019) Pablo Sánchez-Martín et al.   JOURNAL OF MOLECULAR BIOLOGY

Up-regulation of FOXO1 and reduced inflammation by β-hydroxybutyric acid are essential diet restriction benefits against liver injury

(2019) Tomoyuki Miyauchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Regulation of Autophagy: Mechanisms and Diseases

(2019) Chiara Di Malta et al.   Frontiers in Cell and Developmental Biology

Mitochondria—Striking a balance between host and endosymbiont

(2019) Richard J. Youle   SCIENCE

Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity

(2019) José M. Bravo-San Pedro et al.   Cell Metabolism

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal

(2019) Jingyue Jia et al.   DEVELOPMENTAL CELL

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

(2018) Peng Zhao et al.   CELL

Galectins Control mTOR in Response to Endomembrane Damage

(2018) Jingyue Jia et al.   MOLECULAR CELL

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

(2018) Gregory A. Wyant et al.   SCIENCE

GCN5L1/BLOS1 Links Acetylation, Organelle Remodeling, and Metabolism

(2018) Iain Scott et al.   TRENDS IN CELL BIOLOGY

Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids

(2018) Allan Sauvat et al.   EBioMedicine

Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype

(2018) Yajing Peng et al.   AGING CELL

Ferritinophagy/ferroptosis: Iron-related newcomers in human diseases

(2018) Mingzhu Tang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival

(2018) Maja Radulovic et al.   EMBO JOURNAL

Autophagy maintains tumour growth through circulating arginine

(2018) Laura Poillet-Perez et al.   NATURE

mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis

(2017) Wei Wan et al.   MOLECULAR CELL

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy

(2017) Heeseon An et al.   NATURE CELL BIOLOGY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytosolic lipolysis and lipophagy: two sides of the same coin

(2017) Rudolf Zechner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms, Pathophysiology, and Management of Obesity

(2017) Steven B. Heymsfield et al.   NEW ENGLAND JOURNAL OF MEDICINE

SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway

(2017) Xin Gu et al.   SCIENCE

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth

(2017) Chiara Di Malta et al.   SCIENCE

WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

(2017) Daniela Bakula et al.   Nature Communications

Fine-tuning autophagy: from transcriptional to posttranslational regulation

(2016) Joëlle Botti-Millet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

(2016) Chrisovalantis Papadopoulos et al.   EMBO JOURNAL

Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation

(2016) Thanh Ngoc Nguyen et al.   JOURNAL OF CELL BIOLOGY

Precision autophagy directed by receptor regulators – emerging examples within the TRIM family

(2016) Tomonori Kimura et al.   JOURNAL OF CELL SCIENCE

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Unsaturated fatty acids induce non-canonical autophagy

(2015) M. Niso-Santano et al.   EMBO JOURNAL

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

(2015) Tomonori Kimura et al.   JOURNAL OF CELL BIOLOGY

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

(2015) Catherine L. Nezich et al.   JOURNAL OF CELL BIOLOGY

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition

(2014) Michael A. Mandell et al.   DEVELOPMENTAL CELL

Hexokinase-II Positively Regulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition

(2014) David J. Roberts et al.   MOLECULAR CELL

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

FOXO transcription factors: key regulators of cellular quality control

(2014) Ashley E. Webb et al.   TRENDS IN BIOCHEMICAL SCIENCES

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex

(2014) Sulochanadevi Baskaran et al.   eLife

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

FIP200 regulates targeting of Atg16L1 to the isolation membrane

(2013) Taki Nishimura et al.   EMBO REPORTS

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

(2013) Naonobu Fujita et al.   JOURNAL OF CELL BIOLOGY

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Regulation of autophagy by stress-responsive transcription factors

(2013) Federico Pietrocola et al.   SEMINARS IN CANCER BIOLOGY

ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex

(2012) Endalkachew Ashenafi Alemu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets

(2012) Anoop Kumar G. Velikkakath et al.   MOLECULAR BIOLOGY OF THE CELL

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

(2012) Alejo Efeyan et al.   NATURE

Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex–dependent and –independent autophagy

(2012) Noor Gammoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Inhibition of autophagy by TAB2 and TAB3

(2011) Alfredo Criollo et al.   EMBO JOURNAL

Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition

(2011) Robert W. Gilkerson et al.   HUMAN MOLECULAR GENETICS

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA