Tripartite-motif protein 21 knockdown extenuates LPS-triggered neurotoxicity by inhibiting microglial M1 polarization via suppressing NF-κB-mediated NLRP3 inflammasome activation

Quantitative assessment of changes in lesser trochanter shapes in relation to femoral rotations

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Rg1 improves LPS-induced Parkinsonian symptoms in mice via inhibition of NF-κB signaling and modulation of M1/M2 polarization

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Upregulated E3 ligase tripartite motif‐containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor‐κB p65 subunit and promotes inflammation in keratinocytes

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Melatonin attenuates choroidal neovascularization by regulating macrophage/microglia polarization via inhibition of RhoA/ROCK signaling pathway

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Amisulpride alleviates chronic mild stress-induced cognitive deficits: Role of prefrontal cortex microglia and Wnt/β-catenin pathway

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Beta-naphthoflavone inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf-2/HO-1-NF-κB signaling axis

(2020) Xiyu Gao et al.   IMMUNOBIOLOGY

Cudraflavanone B Isolated from the Root Bark of Cudrania tricuspidata Alleviates Lipopolysaccharide-Induced Inflammatory Responses by Downregulating NF-κB and ERK MAPK Signaling Pathways in RAW264.7 Macrophages and BV2 Microglia

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Anti-inflammatory effects of higenamine (Hig) on LPS-activated mouse microglia (BV2) through NF-κB and Nrf2/HO-1 signaling pathways

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Apamin Suppresses LPS-Induced Neuroinflammatory Responses by Regulating SK Channels and TLR4-Mediated Signaling Pathways

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Therapeutic potential of prenylated stilbenoid macasiamenene F through its anti-inflammatory and cytoprotective effects on LPS-challenged monocytes and microglia

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Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells

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Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime

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Distribution and polarization of microglia and macrophages at injured sites and the lumbar enlargement after spinal cord injury

(2020) Hideaki Nakajima et al.   NEUROSCIENCE LETTERS

Phoenixin-20 Ameliorates Lipopolysaccharide-Induced Activation of Microglial NLRP3 Inflammasome

(2020) Xiangliang Zeng et al.   NEUROTOXICITY RESEARCH

MitoQ attenuates brain damage by polarizing microglia towards the M2 phenotype through inhibition of the NLRP3 inflammasome after ICH

(2020) Weixiang Chen et al.   PHARMACOLOGICAL RESEARCH

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Blueberry Counteracts BV-2 Microglia Morphological and Functional Switch after LPS Challenge

(2020) Maria Giovanna De Caris et al.   Nutrients

Efficient Strategies for Microglia Replacement in the Central Nervous System

(2020) Zhen Xu et al.   Cell Reports

Electroconvulsive stimulation attenuates chronic neuroinflammation

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Gene therapy for Alzheimer’s disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation

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T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease

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Neuroinflammation Mediated by NLRP3 Inflammasome After Intracerebral Hemorrhage and Potential Therapeutic Targets

(2020) Linglong Xiao et al.   MOLECULAR NEUROBIOLOGY

Antifungal drug miconazole ameliorated memory deficits in a mouse model of LPS-induced memory loss through targeting iNOS

(2020) In Jun Yeo et al.   Cell Death & Disease

The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer’s disease

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Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway

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Biglycan regulates neuroinflammation by promoting M1 microglial activation in early brain injury after experimental subarachnoid hemorrhage

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HDAC9 promotes brain ischemic injury by provoking IκBα/NF-κB and MAPKs signaling pathways

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Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer’s disease

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The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

(2018) Shuo Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production

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Protein arginine methyltransferase 5 has prognostic relevance and is a druggable target in multiple myeloma

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Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

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(2015) Moritz Haneklaus et al.   IMMUNOLOGICAL REVIEWS

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(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-  Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

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Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Prostaglandin E2-Induced Cell Death is Mediated by Activation of EP2 Receptors in Motor Neuron-like NSC-34 Cells

(2013) Hiroko Miyagishi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

(2013) William A McEwan et al.   NATURE IMMUNOLOGY

NF-κB contributes to the detrimental effects of social isolation after experimental stroke

(2012) Venugopal Reddy Venna et al.   ACTA NEUROPATHOLOGICA

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

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3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3

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Ro52-mediated Monoubiquitination of IKK  Down-regulates NF- B Signalling

(2009) K. Wada et al.   JOURNAL OF BIOCHEMISTRY

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(2009) Zong-Ping Xia et al.   NATURE

NF- B as a Critical Link Between Inflammation and Cancer

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Biochemical and Biophysical Characterization of a Chimeric TRIM21-TRIM5  Protein

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