Biglycan regulates neuroinflammation by promoting M1 microglial activation in early brain injury after experimental subarachnoid hemorrhage

Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells

(2019) Hui Shi et al.   MOLECULES

LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats

(2019) Jianhua Peng et al.   Redox Biology

Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury

(2019) Chiara Poluzzi et al.   KIDNEY INTERNATIONAL

The proteoglycan biglycan mediates inflammatory response by activating TLR-4 in human chondrocytes: Inhibition by specific siRNA and high polymerized Hyaluronan

(2018) Angela Avenoso et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage

(2018) Yue Lu et al.   Journal of Neuroinflammation

Biglycan is a new high-affinity ligand for CD14 in macrophages

(2018) Heiko Roedig et al.   MATRIX BIOLOGY

Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney

(2018) Madalina Viviana Nastase et al.   MATRIX BIOLOGY

A role for proteoglycans in vascular disease

(2018) Thomas N. Wight   MATRIX BIOLOGY

Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice

(2018) Jinwei Pang et al.   Translational Stroke Research

The regulatory role of Toll-like receptors after ischemic stroke: neurosteroids as TLR modulators with the focus on TLR2/4

(2018) Saeedeh Tajalli-Nezhad et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Subarachnoid Hemorrhage

(2017) Michael T. Lawton et al.   NEW ENGLAND JOURNAL OF MEDICINE

RIPK3 interactions with MLKL and CaMKII mediate oligodendrocytes death in the developing brain

(2017) Yi Qu et al.   Cell Death & Disease

Peli1 Contributions in Microglial Activation, Neuroinflammatory Responses and Neurological Deficits Following Experimental Subarachnoid Hemorrhage

(2017) Xue-Ping Huang et al.   Frontiers in Molecular Neuroscience

High-Throughput Sequencing and Co-Expression Network Analysis of lncRNAs and mRNAs in Early Brain Injury Following Experimental Subarachnoid Haemorrhage

(2017) Jianhua Peng et al.   Scientific Reports

Interleukin-6, MCP-1, IP-10, and MIG are sequentially expressed in cerebrospinal fluid after subarachnoid hemorrhage

(2016) Aichi Niwa et al.   Journal of Neuroinflammation

Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice

(2016) Fumihiro Kawakita et al.   MOLECULAR NEUROBIOLOGY

An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage

(2016) Yue Wu et al.   NEUROSCIENCE LETTERS

Antidepressant therapies inhibit inflammation and microglial M1-polarization

(2016) Hans O. Kalkman et al.   PHARMACOLOGY & THERAPEUTICS

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Melatonin attenuates inflammatory response-induced brain edema in early brain injury following a subarachnoid hemorrhage: a possible role for the regulation of pro-inflammatory cytokines

(2014) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury

(2014) Kristin Moreth et al.   MATRIX BIOLOGY

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasticity of Cerebrovascular Smooth Muscle Cells After Subarachnoid Hemorrhage

(2014) Lars Edvinsson et al.   Translational Stroke Research

Biological interplay between proteoglycans and their innate immune receptors in inflammation

(2013) Helena Frey et al.   FEBS Journal

The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage

(2013) Khalid A Hanafy   Journal of Neuroinflammation

Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway

(2013) Zhong Wang et al.   JOURNAL OF PINEAL RESEARCH

De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways

(2013) Jinyang Zeng-Brouwers et al.   MATRIX BIOLOGY

Controversies and evolving new mechanisms in subarachnoid hemorrhage

(2013) Sheng Chen et al.   PROGRESS IN NEUROBIOLOGY

The importance of early brain injury after subarachnoid hemorrhage

(2012) Fatima A. Sehba et al.   PROGRESS IN NEUROBIOLOGY

The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis

(2010) Kristin Moreth et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll-like receptor 4 in CNS pathologies

(2010) Madison M. Buchanan et al.   JOURNAL OF NEUROCHEMISTRY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model

(2007) Takashi Sugawara et al.   JOURNAL OF NEUROSCIENCE METHODS