Upregulated E3 ligase tripartite motif‐containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor‐κB p65 subunit and promotes inflammation in keratinocytes

E3 ligase Trim21 ubiquitylates and stabilizes Keratin 17 to induce STAT3 activation in psoriasis

(2018) Luting Yang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis

(2018) Cristina Albanesi et al.   Frontiers in Immunology

Psoriasis: Keratinocytes or Immune Cells – Which Is the Trigger?

(2018) Farida Benhadou et al.   DERMATOLOGY

Stat3 activation in epidermal keratinocytes induces Langerhans cell activation to form an essential circuit for psoriasis via IL-23 production

(2018) Kimiko Nakajima et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

TRIM21 Restricts Coxsackievirus B3 Replication, Cardiac and Pancreatic Injury via Interacting With MAVS and Positively Regulating IRF3-Mediated Type-I Interferon Production

(2018) Hui Liu et al.   Frontiers in Immunology

Vascular endothelial growth factor driving aberrant keratin expression pattern contributes to the pathogenesis of psoriasis

(2017) Man Jiang et al.   EXPERIMENTAL CELL RESEARCH

TRIM21 is important in the early phase of inflammation in the imiquimod-induced psoriasis-like skin inflammation mouse model

(2017) Hanne Vinter et al.   EXPERIMENTAL DERMATOLOGY

Genes directly regulated by NF-κB in human hepatocellular carcinoma HepG2

(2017) Wei Dai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Molecular Mechanisms and Management of a Cutaneous Inflammatory Disorder: Psoriasis

(2017) Yu Woo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tripartite motif-containing (TRIM) 21 negatively regulates intestinal mucosal inflammation through inhibiting T H 1/T H 17 cell differentiation in patients with inflammatory bowel diseases

(2017) Guangxi Zhou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chemokine CCL2–CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus

(2017) Dai-Shi Tian et al.   JOURNAL OF NEUROSCIENCE

Promoting effects of IL-23 on myocardial ischemia and reperfusion are associated with increased expression of IL-17A and upregulation of the JAK2-STAT3 signaling pathway

(2017) Yanxi Liao et al.   Molecular Medicine Reports

Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet’s disease

(2017) Yuri Ahn et al.   Scientific Reports

Ubiquitination-Linked Phosphorylation of the FANCI S/TQ Cluster Contributes to Activation of the Fanconi Anemia I/D2 Complex

(2017) Ronald S. Cheung et al.   Cell Reports

CCN1 promotes IL-1β production in keratinocytes by activating p38 MAPK signaling in psoriasis

(2017) Yue Sun et al.   Scientific Reports

TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells

(2016) Jeffrey Q. Nguyen et al.   CANCER BIOLOGY & THERAPY

STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia

(2016) Feng-Ting Liu et al.   Oncotarget

The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming

(2016) Bharathi Suresh et al.   Stem Cells International

The Regulation of NF-κB Subunits by Phosphorylation

(2016) Frank Christian et al.   Cells

NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis

(2015) Sha Yan et al.   Nature Communications

TRIpartite Motif 21 (TRIM21) Differentially Regulates the Stability of Interferon Regulatory Factor 5 (IRF5) Isoforms

(2014) Elisa Lazzari et al.   PLoS One

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

(2013) William A McEwan et al.   NATURE IMMUNOLOGY

NF-κB-Induced IL-6 Ensures STAT3 Activation and Tumor Aggressiveness in Glioblastoma

(2013) Braden C. McFarland et al.   PLoS One

Stat3 Inhibition Attenuates Mechanical Allodynia through Transcriptional Regulation of Chemokine Expression in Spinal Astrocytes

(2013) Xiaodong Liu et al.   PLoS One

NF-κB: An essential transcription factor in psoriasis

(2012) A.M. Goldminz et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

TRIM Protein-Mediated Regulation of Inflammatory and Innate Immune Signaling and Its Association with Antiretroviral Activity

(2012) P. D. Uchil et al.   JOURNAL OF VIROLOGY

Essential role of cooperative NF-κB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma

(2012) D Kesanakurti et al.   ONCOGENE

Respiratory Syncytial Virus-Mediated NF- B p65 Phosphorylation at Serine 536 Is Dependent on RIG-I, TRAF6, and IKK 

(2010) F. Yoboua et al.   JOURNAL OF VIROLOGY

Downregulation of active IKKβ by Ro52-mediated autophagy

(2010) Motoko Niida et al.   MOLECULAR IMMUNOLOGY

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway

(2009) Alexander Espinosa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gene Disruption Study Reveals a Nonredundant Role for TRIM21/Ro52 in NF- B-Dependent Cytokine Expression in Fibroblasts

(2009) R. Yoshimi et al.   JOURNAL OF IMMUNOLOGY