Article
Immunology
Pingping Li, Xuefei Ji, Ming Shan, Yi Wang, Xingliang Dai, Mengyuan Yin, Yunlong Liu, Liao Guan, Lei Ye, Hongwei Cheng
Summary: In this study, a model of temporal lobe epilepsy (TLE) was established in mice using kainic acid (KA), and melatonin (MEL) was used for treatment. The results showed that MEL reduced the frequency and severity of seizures, improved cognition, learning, and memory ability, and significantly reduced neuronal death in the hippocampus. In vitro experiments showed that MEL changed the polarization status of microglia from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype by regulating the RhoA/ROCK signaling pathway.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Immunology
Kei Takahashi, Shinsuke Nakamura, Wataru Otsu, Masamitsu Shimazawa, Hideaki Hara
Summary: The study indicates that PGRN deficiency activates lysosomal function in Iba-1(+) cells, leading to abnormal inflammation. This aberrant activation may contribute to the progression of CNV, and regulating these cells could be a novel therapeutic target for exudative AMD.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Plant Sciences
Yehao Zhang, Lan Miao, Qing Peng, Xiaodi Fan, Wenting Song, Bin Yang, Peng Zhang, Guangyu Liu, Jianxun Liu
Summary: The study demonstrates that Parthenolide (PTL) can regulate neuroinflammation and protect against ischemic brain injury by modulating microglial polarization via the RhoA/ROCK pathway.
Article
Multidisciplinary Sciences
Daniel Duck-Jin Hwang, Seong Choi, Junseo Ko, Jeewoo Yoon, Ji In Park, Joon Seo Hwang, Jeong Mo Han, Hak Jun Lee, Joonhong Sohn, Kyu Hyung Park, Jinyoung Han
Summary: This study successfully distinguished between RAP and PCV cases in neovascular age-related macular degeneration using a deep learning model, showing high accuracy, sensitivity, and specificity. The novel model performed well in distinguishing between PCV and RAP, demonstrating better diagnostic performance than other models and comparable performance with ophthalmologists.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Siva P. Kambhampati, Imran A. Bhutto, Tony Wu, Katie Ho, D. Scott McLeod, Gerard A. Lutty, Rangaramanujam M. Kannan
Summary: The study demonstrates a potential systemic therapy approach for selectively targeting and inhibiting the progression of AMD, showing promising efficacy in animal models and human postmortem studies.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Tu Lu, Fangfang Xie, Chuangxin Huang, Lijun Zhou, Kunbei Lai, Yajun Gong, Zijing Li, Longhui Li, Jiandong Liang, Qifeng Cong, Weihua Li, Rong Ju, Sarah X. Zhang, Chenjin Jin
Summary: ERp29 attenuates nicotine-induced ER stress, regulates macrophage polarization, and inhibits the occurrence of CNV.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Tianxi Wang, Pingzhu Zhou, Xuemei Xie, Yohei Tomita, Steve Cho, Demetrios Tsirukis, Enton Lam, Hongbo Robert Luo, Ye Sun
Summary: The study revealed that myeloid lineage cells played a significant role in regulating pathological CNV formation via SOCS3, as demonstrated in mouse models.
Article
Biochemical Research Methods
Pinghui Wei, Meiqin He, Guoge Han
Summary: We conducted untargeted metabolomics analysis to study the metabolic alterations in a CNV rat model. The results showed specific metabolic patterns in different ocular tissues and potential substance exchange between tissues. Dysregulated metabolomic profiles in differential tissues may be related to oxidative stress response, resulting in RPE cell degeneration and CNV development.
JOURNAL OF PROTEOME RESEARCH
(2022)
Review
Ophthalmology
Riccardo Sacconi, Serena Fragiotta, David Sarraf, SriniVas R. Sadda, K. Bailey Freund, Mariacristina Parravano, Giulia Corradetti, Diogo Cabral, Vittorio Capuano, Alexandra Miere, Eliana Costanzo, Francesco Bandello, Eric Souied, Giuseppe Querques
Summary: Non-exudative macular and choroidal neovascularization (MNV and CNV) refers to treatment-naive type 1 neovascularization without exudation. This entity was first reported in the late 90s and has been increasingly recognized with advanced retinal imaging. However, there is a lack of consensus regarding the definition and clinical management. This review discusses the prevalence, imaging features, clinical course, and response to treatment of non-exudative MNV and CNV, providing key insights and proposing a new theory about their origin and course.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
Article
Cell Biology
Christine M. Sorenson, Mitra Farnoodian, Shoujian Wang, Yong-Seok Song, Soesiawati R. Darjatmoko, Arthur S. Polans, Nader Sheibani
Summary: This paper investigates the potential of using S1PR agonists to inhibit choroidal neovascularization. Through in vitro and in vivo experiments, it is confirmed that S1PR1 is the most abundantly expressed receptor in choroidal endothelial cells and S1PR agonists can significantly suppress choroidal neovascularization. These findings suggest a potential new application for S1PR agonists in the treatment of nAMD and other inflammation-related diseases.
Article
Ophthalmology
Jae Yong Park, Min-Ji Kang, Bum Gi Kim, Kyu Ho Chung, Ha Eun Sim, Seong Woo Lee, Jae Suk Kim, Hyeon Seok Lee, Je Hyung Hwang
Summary: The study found that during the development of CNV, there is a significant increase in choroidal thickness in the corresponding subfield. Additionally, three months before the development of CNV, the choroidal thickness in the central subfield also significantly increases. Regular measurement of choroidal thickness may help in predicting CNV development.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Immunology
Xia Cai, Yang Shi, Yue Dai, Fang Wang, Xuepeng Chen, Xiaojun Li
Summary: Baicalin enhances efferocytosis by promoting macrophage engulfment of apoptotic PMNs, inhibiting reactive oxygen species production, and regulating macrophage polarization, thus promoting resolution of inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Gideon Obasanmi, Matthew R. Zeglinski, Ella Hardie, Anna-Catharina Wilhelm, Christopher T. Turner, Sho Hiroyasu, Wendy A. Boivin, Yuan Tian, Hongyan Zhao, Eleanor To, Jing Z. Cui, Jeanne Xi, Hyung-Suk Yoo, Manjosh Uppal, David J. Granville, Joanne A. Matsubara
Summary: Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss in the elderly and is associated with abnormal blood vessel growth. This study explored the relationship between the protease Granzyme B (GzmB) and the antiangiogenic factors Thrombospondin (TSP)-1 and TSP-2 in eyes with neovascular AMD. The study found that TSP-1 and TSP-2 are substrates of GzmB and that the proteolysis of these factors by GzmB may contribute to neovascular AMD-related choroidal neovascularization (CNV).
LABORATORY INVESTIGATION
(2023)
Article
Cell Biology
Wendie Li, Ying Wang, Linling Zhu, Shu Du, Jinghai Mao, Yanyan Wang, Sangsang Wang, Qingyun Bo, Yuanyuan Tu, QuanYong Yi
Summary: The study revealed that the p300/XBP1s/Herpud1 axis promotes M2 polarization of macrophages and inhibits proliferation, migration, and tube formation of MCECs. Additionally, this axis increases in infiltrating M2-type macrophages in mouse CNV lesions induced by laser. Blocking the p300/XBP1s/Herpud1 axis can inhibit macrophage M2 polarization and alleviate CNV lesions.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medical Laboratory Technology
Jiali Wu, Jieqiong Chen, Jing Hu, Mudi Yao, Min Zhang, Xiaoling Wan, Huixun Jia, Fenghua Wang, Xiaodong Sun
Summary: Age-related macular degeneration (AMD) is a major cause of irreversible blindness in the elderly, especially its neovascular form characterized by choroidal neovascularization (CNV). This study explored the role of circular RNA Uxs1 in CNV regulation and found it to be consistently upregulated in CNV patient specimens and mouse models. CirRNA Uxs1 promotes CNV by sponging miR-335-5p, which leads to the upregulation of placental growth factor (PGF) gene and activation of the mTOR/p70 S6k pathway. These findings suggest that circRNA Uxs1 may serve as a potential therapeutic target for CNV.
TRANSLATIONAL RESEARCH
(2023)
Article
Ophthalmology
Jianqiang Lin, Kaixuan Cui, Yue Xu, Xiaoyu Tang, Yuxun Shi, Xi Lu, Boyu Yang, Qingjing He, Shanshan Yu, Xiaoling Liang
Summary: The study found that CD146 is involved in retinal neovascularization via the VEGFR2 pathway. Anti-CD146 may provide a new direction for the treatment of PDR and other ocular neovascular diseases.
ACTA OPHTHALMOLOGICA
(2022)
Article
Cell Biology
Jia Li, Xi Lu, Liqing Wei, Dan Ye, Jianqiang Lin, Xiaoyu Tang, Kaixuan Cui, Shanshan Yu, Yue Xu, Xiaoling Liang
Summary: The study demonstrates that PHD2 plays a crucial role in maintaining the functions of hRMECs under hyperglycemic conditions by inhibiting HIF-1 activity, suggesting that it could be a potential novel target for the treatment of DME or other diseases with a similar pathogenesis.
INFLAMMATION RESEARCH
(2022)
Article
Ophthalmology
Xinyu Zhao, Jianqiang Lin, Shanshan Yu, Liqiong Xie, Ling Jin, Kun Xiong, Ching-Kit Tsui, Yue Xu, Benjuan Wu, Bin Liu, Wei Wang, Nathan Congdon, Wenyong Huang, Mingguang He, Xiaoling Liang
Summary: This study aimed to report the 6-year incidence, causes, and risk factors for vision loss (visual impairment and blindness) among elderly adults in rural southern China. The study found that cataract and refractive errors were the most common causes of vision loss. Older age, female sex, lower education, living alone, and longer axial length were significantly associated with greater incident vision loss.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Endocrinology & Metabolism
Shanshan Yu, Kaixuan Cui, Peiqi Wu, Benjuan Wu, Xi Lu, Rong Huang, Xiaoyu Tang, Jianqiang Lin, Boyu Yang, Jinfeng Zhao, Qingjing He, Xiaoling Liang, Yue Xu
Summary: This study suggests that melatonin could be a promising and safe therapeutic strategy for central serous chorioretinopathy (CSC) patients. Melatonin administration inhibited choroidal thickening, vasodilation, and inflammation in an experimental CSC rat model.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Thermodynamics
Changxin Liu, Huaan Li, Shanshan Yu, Guanghao Qu, Wenxiang Ye, Zhitao Han, Minyi Xu, Xinxiang Pan
Summary: The TEG-ORC combined cycle is a promising method for utilizing waste heat from multiple vessels. By using low toxicity and environmental friendly R245fa as the working fluid, and controlling different bottom cycle ratios and superheating, the system's net power output and thermal efficiency can be improved while reducing the power-production cost.
INTERNATIONAL JOURNAL OF GREEN ENERGY
(2023)
Article
Hematology
Peiyu Yang, Haimin Chen, Xinyue Liang, Weiling Xu, Shanshan Yu, Wenyang Huang, Xingcheng Yi, Qiang Guo, Mengru Tian, Tingting Yue, Mengyao Li, Yingjie Zhang, Mengxue Zhang, Yurong Yan, Zhongli Hu, Shaji K. Kumar, Fan Zhou, Yun Dai, Fengyan Jin
Summary: This study retrospectively analyzed the impact of +1q on the outcomes of 934 newly diagnosed multiple myeloma patients. The results showed that +1q was associated with inferior overall survival, and the concomitance of other high-risk cytogenetic abnormalities further exacerbated the outcomes. A risk-scoring algorithm based on four risk variates was developed to estimate the outcomes of +1q patients.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Ophthalmology
Boyu Yang, Shaowen Wu, Shanshan Yu, Xiaoling Liang, Qifa Liu, Fen Huang, Lingyi Liang
Summary: This study aimed to investigate the posterior segment complications (PSC) and risk factors in patients after allogeneic hematopoietic stem cell transplantation (HSCT). The study found that PSC was more common in post-HSCT patients and was associated with unrelated or HLA-mismatched donors.
Article
Medicine, Research & Experimental
Chen-Xi Cai, Xiao-Mei Xiong, Tao Li, Bing-Qian Liu, Xin-Hua Huang, Shan-Shan Yu, Zhen-Qiang Lin, Qiang Wang, Jin-Li Cui, Lin Lu, Ying Lin
Summary: ICGA can be used to evaluate the differences in filling degree and appearance of vortex veins in various eye diseases. The CVVD and MDPTB were significantly increased in the PCV compared with those in the AMD group; the CVVD, MRAV, and PVVA were significantly increased in the PCV compared with those in the healthy group. The vortex vein branches in PCV eyes were significantly dilated in the posterior pole, and the lower proportion of type IV vortex veins may be pathognomonic for PCV.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Ophthalmology
Tingxin Cui, Duoru Lin, Shanshan Yu, Xinyu Zhao, Zhenzhe Lin, Lanqin Zhao, Fabao Xu, Dongyuan Yun, Jianyu Pang, Ruiyang Li, Liqiong Xie, Pengzhi Zhu, Yuzhe Huang, Hongxin Huang, Changming Hu, Wenyong Huang, Xiaoling Liang, Haotian Lin
Summary: This study explores the performance of a deep learning system (DLS) for multiple retinal lesion screening using ultra-widefield (UWF) fundus images from patients in rural areas. The findings indicate that the DLS exhibits excellent performance as a screening tool for detecting retinal lesions in a rural setting, although factors such as poor image quality, diverse lesion proportions, and complex lesion composition may have reduced its performance.
JAMA OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Zhonghua Luo, Yue Xu, Kun Xu, Matthew Fan, Ching-Kit Tsui, Xi Lu, Benjuan Wu, Xinyu Zhao, Xiaoyu Tang, Peiqi Wu, Kaixuan Cui, Shanshan Yu, Xiaoling Liang
Summary: This study evaluated the differences in the choroidal vortex vein drainage system between patients with CSC and healthy individuals using UWF-OCTA. The results showed that CSC eyes have an asymmetric vortex vein drainage system, with the superotemporal drainage system being the preferential route for submacular choroidal drainage.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Editorial Material
Ophthalmology
Xinqi Ma, Shanshan Yu
OPHTHALMOLOGY RETINA
(2023)
Article
Cell Biology
Xinyu Zhao, Zhenzhe Lin, Shanshan Yu, Jun Xiao, Liqiong Xie, Yue Xu, Ching-Kit Tsui, Kaixuan Cui, Lanqin Zhao, Guoming Zhang, Shaochong Zhang, Yan Lu, Haotian Lin, Xiaoling Liang, Duoru Lin
Summary: An artificial intelligence system called Ai-Doctor was developed to interpret fundus fluorescein angiography (FFA) images for the diagnosis and treatment of ischemic retinal diseases (IRDs). The system performed well in various tasks, such as image identification, diabetic retinopathy and branch retinal vein occlusion diagnosis, and non-perfusion area segmentation. It was also able to expand its capabilities to previously unencountered IRDs. A new clinically applicable ischemia index was proposed to assess the degree of ischemia and guide laser therapy.
CELL REPORTS MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yumei Li, Tianyi Chen, Ying Xue, Yuan Wang, Li Peng, Chenglong Wang, Shanshan Yu
Summary: DJ-1 has been found to have neuroprotective effects and can inhibit ferroptosis. This study revealed that the neuroprotective effect of DJ-1 is closely related to the ATF4/HSPA5 pathway.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Ophthalmology
Xiaoyu Tang, Kaixuan Cui, Xi Lu, Peiqi Wu, Shanshan Yu, Boyu Yang, Yue Xu, Xiaoling Liang
Summary: Using animal models and in vitro cell experiments, it was found that KC7F2 effectively inhibits retinal neovascularization by suppressing the HIF1α-VEGF pathway.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
