Therapeutic Cancer Vaccines Revamping: Technology Advancements and Pitfalls

Longitudinal tracking of 97 esophageal adenocarcinomas using liquid biopsy sampling

(2021) E. Ococks et al.   ANNALS OF ONCOLOGY

Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma

(2021) Zhuting Hu et al.   NATURE MEDICINE

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

(2021) Eryn Blass et al.   Nature Reviews Clinical Oncology

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

(2021) Christina Krienke et al.   SCIENCE

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

(2021) Kevin Litchfield et al.   CELL

How did we Get a COVID-19 Vaccine in Less Than 1 Year?

(2021) E. John Wherry et al.   CLINICAL CANCER RESEARCH

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

(2021) Denis Y Logunov et al.   LANCET

Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib: a clinical validation study

(2021) Mahrukh M Syeda et al.   LANCET ONCOLOGY

mRNA vaccine for cancer immunotherapy

(2021) Lei Miao et al.   Molecular Cancer

mRNA in cancer immunotherapy: beyond a source of antigen

(2021) Lien Van Hoecke et al.   Molecular Cancer

Intratumoral heterogeneity in cancer progression and response to immunotherapy

(2021) Ilio Vitale et al.   NATURE MEDICINE

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

(2021) Noa Dagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutralizing Activity of BNT162b2-Elicited Serum

(2021) Yang Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor Burden and Immunotherapy: Impact on Immune Infiltration and Therapeutic Outcomes

(2021) Samuel I. Kim et al.   Frontiers in Immunology

Characterization of a novel OX40 ligand and CD40 ligand-expressing oncolytic adenovirus used in the PeptiCRAd cancer vaccine platform

(2021) Erkko Ylösmäki et al.   Molecular Therapy-Oncolytics

High tumor mutation burden fails to predict immune checkpoint blockade response across all cancer types

(2021) D.J. McGrail et al.   ANNALS OF ONCOLOGY

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

(2021) Stefan C. Dentro et al.   CELL

mRNA therapeutics in cancer immunotherapy

(2021) Jan D. Beck et al.   Molecular Cancer

Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons

(2021) Tom T. Shimabukuro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas

(2021) Gregory K. Friedman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19

(2021) Nicole Doria-Rose et al.   NEW ENGLAND JOURNAL OF MEDICINE

mRNA vaccines manufacturing: Challenges and bottlenecks

(2021) Sara Sousa Rosa et al.   VACCINE

Exploiting Tumor Neoantigens to Target Cancer Evolution: Current Challenges and Promising Therapeutic Approaches

(2021) Ravi G. Gupta et al.   Cancer Discovery

Phase I study of a multitargeted recombinant Ad5 PSA/MUC-1/brachyury-based immunotherapy vaccine in patients with metastatic castration-resistant prostate cancer (mCRPC)

(2021) Marijo Bilusic et al.   Journal for ImmunoTherapy of Cancer

HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy

(2021) Ana Marcu et al.   Journal for ImmunoTherapy of Cancer

T Cell Epitope Predictions

(2020) Bjoern Peters et al.   Annual Review of Immunology

Top 10 Challenges in Cancer Immunotherapy

(2020) Priti S. Hegde et al.   IMMUNITY

A phase I study to evaluate the safety and tolerability of AB680 combination therapy in participants with gastrointestinal malignancies.

(2020) Johanna C. Bendell et al.   JOURNAL OF CLINICAL ONCOLOGY

Pan-cancer analysis of whole genomes

(2020)   NATURE

Frontline immunotherapy for NSCLC — the tale of the tail

(2020) Anne C. Chiang et al.   Nature Reviews Clinical Oncology

The promise of mRNA vaccines: a biotech and industrial perspective

(2020) Nicholas A. C. Jackson et al.   npj Vaccines

Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance

(2020) Andriy Marusyk et al.   CANCER CELL

The Challenges of Vaccine Development against a New Virus during a Pandemic

(2020) Michael S. Diamond et al.   Cell Host & Microbe

Small molecules, big impact: 20 years of targeted therapy in oncology

(2020) Philippe L Bedard et al.   LANCET

Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma

(2020) Xing Hua et al.   Nature Communications

Neoantigen prediction and computational perspectives towards clinical benefit: recommendations from the ESMO Precision Medicine Working Group

(2020) L. De Mattos-Arruda et al.   ANNALS OF ONCOLOGY

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

(2020) Yuanyuan Zhang et al.   Cellular & Molecular Immunology

Recent advances in mRNA vaccine technology

(2020) Norbert Pardi et al.   CURRENT OPINION IN IMMUNOLOGY

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

(2020) Jackie E. Bader et al.   MOLECULAR CELL

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

(2020) Ugur Sahin et al.   NATURE

Safety and immunogenicity of novel 5T4 viral vectored vaccination regimens in early stage prostate cancer: a phase I clinical trial

(2020) Federica Cappuccini et al.   Journal for ImmunoTherapy of Cancer

Multiplex bioimaging of single-cell spatial profiles for precision cancer diagnostics and therapeutics

(2020) Mayar Allam et al.   npj Precision Oncology

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer

(2020) Patrick A. Ott et al.   CELL

Personalized Cancer Vaccines: Clinical Landscape, Challenges, and Opportunities

(2020) Colby S. Shemesh et al.   MOLECULAR THERAPY

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

(2020) Evan J. Anderson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TAS0314, a novel multi-epitope long peptide vaccine, showed synergistic antitumor immunity with PD-1/PD-L1 blockade in HLA-A*2402 mice

(2020) Yuki Tanaka et al.   Scientific Reports

The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study

(2020) Marco Punta et al.   Frontiers in Immunology

Immunomodulation by targeted anticancer agents

(2020) Giulia Petroni et al.   CANCER CELL

First‐in‐human study of the cancer peptide vaccine, TAS0313, in patients with advanced solid tumors

(2020) Shunsuke Kondo et al.   CANCER SCIENCE

Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy

(2020) Satyen H. Gohil et al.   Nature Reviews Clinical Oncology

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Roadmap Toward the Definition of Actionable Tumor-Specific Antigens

(2020) Robin Minati et al.   Frontiers in Immunology

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Turning the corner on therapeutic cancer vaccines

(2019) Robert E. Hollingsworth et al.   npj Vaccines

Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer

(2019) Alexandros Papachristofilou et al.   Journal for ImmunoTherapy of Cancer

Mutational and Antigenic Landscape in Tumor Progression and Cancer Immunotherapy

(2019) Ilio Vitale et al.   TRENDS IN CELL BIOLOGY

Recent advances in triple negative breast cancer: the immunotherapy era

(2019) Antonio Marra et al.   BMC Medicine

Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication

(2019) Sean K. Maynard et al.   BMC CANCER

Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection

(2019) Chen Yao et al.   NATURE IMMUNOLOGY

Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade

(2019) Anna Morena D’Alise et al.   Nature Communications

Final analyses of OPTiM: a randomized phase III trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor in unresectable stage III–IV melanoma

(2019) Robert H. I. Andtbacka et al.   Journal for ImmunoTherapy of Cancer

Peptides as cancer vaccines

(2019) Marta Calvo Tardón et al.   CURRENT OPINION IN PHARMACOLOGY

Circulating biomarkers predictive of tumor response to cancer immunotherapy

(2019) Ernest Y. Lee et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors

(2019) Li Zhu et al.   Journal for ImmunoTherapy of Cancer

A large peptidome dataset improves HLA class I epitope prediction across most of the human population

(2019) Siranush Sarkizova et al.   NATURE BIOTECHNOLOGY

Design and application of oncolytic viruses for cancer immunotherapy

(2019) Erkko Ylösmäki et al.   CURRENT OPINION IN BIOTECHNOLOGY

Regulated intratumoral expression of IL-12 using a RheoSwitch Therapeutic System® (RTS®) gene switch as gene therapy for the treatment of glioma

(2018) John A. Barrett et al.   CANCER GENE THERAPY

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma

(2018) Frederick F. Lang et al.   JOURNAL OF CLINICAL ONCOLOGY

The emerging clinical relevance of genomics in cancer medicine

(2018) Michael F. Berger et al.   Nature Reviews Clinical Oncology

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

(2018) Giulia Escobar et al.   Nature Communications

Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA

(2018) K. G. Paulson et al.   Nature Communications

Tumor Antigen Escape from CAR T-cell Therapy

(2018) Robbie G. Majzner et al.   Cancer Discovery

New Vaccine Technologies to Combat Outbreak Situations

(2018) Susanne Rauch et al.   Frontiers in Immunology

Quick efficacy seeking trial (QuEST1): a novel combination immunotherapy study designed for rapid clinical signal assessment metastatic castration-resistant prostate cancer

(2018) Jason M. Redman et al.   Journal for ImmunoTherapy of Cancer

Immuno-Oncology: Emerging Targets and Combination Therapies

(2018) Henry T. Marshall et al.   Frontiers in Oncology

The clinical role of the TME in solid cancer

(2018) Nicolas A. Giraldo et al.   BRITISH JOURNAL OF CANCER

Cytokines in clinical cancer immunotherapy

(2018) Pedro Berraondo et al.   BRITISH JOURNAL OF CANCER

Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis

(2018) Brian W. Labadie et al.   CLINICAL CANCER RESEARCH

Actively personalized vaccination trial for newly diagnosed glioblastoma

(2018) Norbert Hilf et al.   NATURE

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

(2018) Derin B. Keskin et al.   NATURE

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression

(2018) Arianna Calcinotto et al.   Nature Communications

Mouse Models for Cancer Immunotherapy Research

(2018) Brian Olson et al.   Cancer Discovery

Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction

(2017) Jennifer G. Abelin et al.   IMMUNITY

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

(2017) Jinfang Zhang et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

Tumour heterogeneity and resistance to cancer therapies

(2017) Ibiayi Dagogo-Jack et al.   Nature Reviews Clinical Oncology

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2017) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

First-Ever CAR T-cell Therapy Approved in U.S.

(2017)   Cancer Discovery

mSA2 affinity-enhanced biotin-binding CAR T cells for universal tumor targeting

(2017) Jason J. Lohmueller et al.   OncoImmunology

Assessment of the Safety and Immunogenicity of 2 Novel Vaccine Platforms for HIV-1 Prevention

(2016) Lindsey R. Baden et al.   ANNALS OF INTERNAL MEDICINE

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Materials for non-viral intracellular delivery of messenger RNA therapeutics

(2016) Kevin J. Kauffman et al.   JOURNAL OF CONTROLLED RELEASE

Efficacy of the MAGE-A3 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small-cell lung cancer (MAGRIT): a randomised, double-blind, placebo-controlled, phase 3 trial

(2016) Johan F Vansteenkiste et al.   LANCET ONCOLOGY

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

(2016) Sheng Li et al.   NATURE MEDICINE

The Human Vaccines Project: A roadmap for cancer vaccine development

(2016) Pedro Romero et al.   Science Translational Medicine

Vector-based genetically modified vaccines: Exploiting Jenner’s legacy

(2016) Bahar Ramezanpour et al.   VACCINE

A novel lipid nanoparticle adjuvant significantly enhances B cell and T cell responses to sub-unit vaccine antigens

(2016) Gokul Swaminathan et al.   VACCINE

Viral vectors as vaccine carriers

(2016) Hildegund CJ Ertl   Current Opinion in Virology

Adenoviral vector-based strategies against infectious disease and cancer

(2016) Chao Zhang et al.   Human Vaccines & Immunotherapeutics

Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens

(2016) Sam Afkhami et al.   Molecular Therapy-Methods & Clinical Development

Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy

(2015) L. Zhai et al.   CLINICAL CANCER RESEARCH

Therapeutic cancer vaccines

(2015) Cornelis J.M. Melief et al.   JOURNAL OF CLINICAL INVESTIGATION

ESR1 mutations—a mechanism for acquired endocrine resistance in breast cancer

(2015) Rinath Jeselsohn et al.   Nature Reviews Clinical Oncology

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

Signal Transduction in Cancer

(2015) R. Sever et al.   Cold Spring Harbor Perspectives in Medicine

A quantitative analysis of therapeutic cancer vaccines in phase 2 or phase 3 trial

(2015) Amabel CL Tan et al.   Journal for ImmunoTherapy of Cancer

Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial

(2014) Gary Middleton et al.   LANCET ONCOLOGY

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

(2014) Mahesh Yadav et al.   NATURE

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

HLA-Binding Properties of Tumor Neoepitopes in Humans

(2014) E. F. Fritsch et al.   Cancer Immunology Research

Oncolytic Viruses and Their Application to Cancer Immunotherapy

(2014) E. A. Chiocca et al.   Cancer Immunology Research

Two in one: improving synthetic long peptide vaccines by combining antigen and adjuvant in one molecule

(2014) Gijs G Zom et al.   OncoImmunology

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Immunodominance: A pivotal principle in host response to viral infections

(2012) Ali Akram et al.   CLINICAL IMMUNOLOGY

Viral Vector-Based Therapeutic Cancer Vaccines

(2011) Cecilia Larocca et al.   CANCER JOURNAL

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

Immunoprevention and Immunotherapy of Mammary Carcinoma

(2010) Pier-Luigi Lollini et al.   Breast Journal

Identification of Genetically Modified Maraba Virus as an Oncolytic Rhabdovirus

(2010) Jan Brun et al.   MOLECULAR THERAPY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Accumulation of driver and passenger mutations during tumor progression

(2010) I. Bozic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viruses as vaccine vectors for infectious diseases and cancer

(2009) Simon J. Draper et al.   NATURE REVIEWS MICROBIOLOGY

Loss of Mismatched HLA in Leukemia after Stem-Cell Transplantation

(2009) Luca Vago et al.   NEW ENGLAND JOURNAL OF MEDICINE