标题
The promise of mRNA vaccines: a biotech and industrial perspective
作者
关键词
-
出版物
npj Vaccines
Volume 5, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-02-04
DOI
10.1038/s41541-020-0159-8
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Improved Efficacy in a Fabry Disease Model Using a Systemic mRNA Liver Depot System as Compared to Enzyme Replacement Therapy
- (2019) Frank DeRosa et al. MOLECULAR THERAPY
- mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases
- (2019) Giulietta Maruggi et al. MOLECULAR THERAPY
- Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
- (2019) Piotr S. Kowalski et al. MOLECULAR THERAPY
- Safety and immunogenicity of a mRNA-based chikungunya vaccine in a phase 1 dose-ranging trial
- (2019) C. Shaw et al. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- Human challenge models: tools to accelerate the development of malaria vaccines
- (2019) Martha M. Cooper et al. Expert Review of Vaccines
- mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials
- (2019) Robert A. Feldman et al. VACCINE
- A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection
- (2019) Nurgun Kose et al. Science Immunology
- Protective Efficacy of Nucleic Acid Vaccines Against Transmission of Zika Virus During Pregnancy in Mice
- (2019) Brett W Jagger et al. JOURNAL OF INFECTIOUS DISEASES
- Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses
- (2018) Norbert Pardi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates
- (2018) Staci Sabnis et al. MOLECULAR THERAPY
- mRNA vaccines — a new era in vaccinology
- (2018) Norbert Pardi et al. NATURE REVIEWS DRUG DISCOVERY
- Base modifications affecting RNA polymerase and reverse transcriptase fidelity
- (2018) Vladimir Potapov et al. NUCLEIC ACIDS RESEARCH
- Arginase I mRNA therapy – A novel approach to rescue arginase 1 enzyme deficiency
- (2018) Kirtika H. Asrani et al. RNA Biology
- Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity
- (2018) Shinu John et al. VACCINE
- Nanoscale platforms for messenger RNA delivery
- (2018) Bin Li et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
- Current Status of Messenger RNA Delivery Systems
- (2018) Matthew G. Stanton Nucleic Acid Therapeutics
- Human organoid cultures: transformative new tools for human virus studies
- (2018) Sasirekha Ramani et al. Current Opinion in Virology
- Non-viral Delivery of Nucleic Acids: Insight Into Mechanisms of Overcoming Intracellular Barriers
- (2018) Mikhail Durymanov et al. Frontiers in Pharmacology
- Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening
- (2018) Alexandra G. Orlandini von Niessen et al. MOLECULAR THERAPY
- Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors
- (2017) Charlotte Lässig et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial
- (2017) Martin Alberer et al. LANCET
- Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses
- (2017) Kapil Bahl et al. MOLECULAR THERAPY
- Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
- (2017) Norbert Pardi et al. NATURE
- Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
- (2017) Kathrin Leppek et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Short poly(A) tails are a conserved feature of highly expressed genes
- (2017) Sarah Azoubel Lima et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation
- (2017) Anna M. Rydzik et al. NUCLEIC ACIDS RESEARCH
- Short poly(A) tails are a conserved feature of highly expressed genes
- (2017) Sarah Azoubel Lima et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia
- (2017) Ding An et al. Cell Reports
- RIG-I: a multifunctional protein beyond a pattern recognition receptor
- (2017) Xiao-xiao Xu et al. Protein & Cell
- Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines
- (2017) Johannes Lutz et al. npj Vaccines
- Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery
- (2016) Owen S. Fenton et al. ADVANCED MATERIALS
- Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo
- (2016) Kevin J. Kauffman et al. BIOMATERIALS
- Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system
- (2016) F DeRosa et al. GENE THERAPY
- Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I
- (2016) Swapnil C. Devarkar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A novel lipid nanoparticle adjuvant significantly enhances B cell and T cell responses to sub-unit vaccine antigens
- (2016) Gokul Swaminathan et al. VACCINE
- Codon Optimality Is a Major Determinant of mRNA Stability
- (2015) Vladimir Presnyak et al. CELL
- N 1 -methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
- (2015) Oliwia Andries et al. JOURNAL OF CONTROLLED RELEASE
- Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals
- (2015) Andreas Thess et al. MOLECULAR THERAPY
- Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
- (2015) Kevin J. Kauffman et al. NANO LETTERS
- Lipid-based mRNA vaccine delivery systems
- (2014) Patrick Midoux et al. Expert Review of Vaccines
- Self-replicating alphavirus RNA vaccines
- (2014) Karl Ljungberg et al. Expert Review of Vaccines
- A novel, disruptive vaccination technology
- (2013) Karl-Josef Kallen et al. Human Vaccines & Immunotherapeutics
- Sequestration by IFIT1 Impairs Translation of 2′O-unmethylated Capped RNA
- (2013) Matthias Habjan et al. PLoS Pathogens
- Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection
- (2012) Benjamin Petsch et al. NATURE BIOTECHNOLOGY
- Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
- (2011) Roland Züst et al. NATURE IMMUNOLOGY
- Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
- (2011) Katalin Karikó et al. NUCLEIC ACIDS RESEARCH
- Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
- (2010) Bart R. Anderson et al. NUCLEIC ACIDS RESEARCH
- The Many Pathways of RNA Degradation
- (2009) Jonathan Houseley et al. CELL
- Locked Nucleic Acid (LNA)-Modified Dinucleotide mRNA Cap Analogue: Synthesis, Enzymatic Incorporation, and Utilization
- (2009) Anilkumar R. Kore et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA
- (2008) Benjamin Weide et al. JOURNAL OF IMMUNOTHERAPY
- Multifunctional deadenylase complexes diversify mRNA control
- (2008) Aaron C. Goldstrohm et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started