标题
mRNA vaccines manufacturing: Challenges and bottlenecks
作者
关键词
Vaccination, mRNA vaccines, mRNA manufacturing, mRNA applications
出版物
VACCINE
Volume 39, Issue 16, Pages 2190-2200
出版商
Elsevier BV
发表日期
2021-03-24
DOI
10.1016/j.vaccine.2021.03.038
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The challenge and prospect of mRNA therapeutics landscape
- (2020) Yuhua Weng et al. BIOTECHNOLOGY ADVANCES
- Flexible Manufacturing: The Future State of Drug Product Development and Commercialization in the Pharmaceutical Industry
- (2020) Yash Kapoor et al. Journal of Pharmaceutical Innovation
- Vaccine Hesitancy: A Growing Concern
- (2020) Jonathan Kennedy PEDIATRIC DRUGS
- Mannosylated Poly(ethylene imine) Copolymers Enhance saRNA Uptake and Expression in Human Skin Explants
- (2020) Anna K. Blakney et al. BIOMACROMOLECULES
- The COVID-19 vaccine development landscape
- (2020) Tung Thanh Le et al. NATURE REVIEWS DRUG DISCOVERY
- An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma
- (2020) Ugur Sahin et al. NATURE
- An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
- (2020) Lisa A. Jackson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Timeline: Vaccines
- (2020) Rino Rappuoli CELL
- Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
- (2020) Evan J. Anderson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination
- (2020) Alicia T. Widge et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
- (2020) Fernando P. Polack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Resources, Production Scales and Time Required for Producing RNA Vaccines for the Global Pandemic Demand
- (2020) Zoltán Kis et al. Vaccines
- Turning the corner on therapeutic cancer vaccines
- (2019) Robert E. Hollingsworth et al. npj Vaccines
- Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes
- (2019) Li-Ming Gan et al. Nature Communications
- Process mapping of vaccines: Understanding the limitations in current response to emerging epidemic threats
- (2019) Georgina Drury et al. VACCINE
- Adoptive Transfer of NKG2D CAR mRNA-Engineered Natural Killer Cells in Colorectal Cancer Patients
- (2019) Lin Xiao et al. MOLECULAR THERAPY
- mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases
- (2019) Giulietta Maruggi et al. MOLECULAR THERAPY
- Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
- (2019) Piotr S. Kowalski et al. MOLECULAR THERAPY
- A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer
- (2019) Martin Sebastian et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Design of in vitro Transcribed mRNA Vectors for Research and Therapy
- (2019) Marina Tusup et al. CHIMIA
- A phase I multicenter study to assess the safety, tolerability, and immunogenicity of mRNA-4157 alone in patients with resected solid tumors and in combination with pembrolizumab in patients with unresectable solid tumors.
- (2019) Howard A. Burris et al. JOURNAL OF CLINICAL ONCOLOGY
- Immunogenicity and tolerability of personalized mRNA vaccine mRNA-4650 encoding defined neoantigens expressed by the autologous cancer.
- (2019) Gal Cafri et al. JOURNAL OF CLINICAL ONCOLOGY
- mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials
- (2019) Robert A. Feldman et al. VACCINE
- A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA
- (2019) Markus Baiersdörfer et al. Molecular Therapy-Nucleic Acids
- Emerging Technologies for Low‐Cost, Rapid Vaccine Manufacture
- (2019) Zoltán Kis et al. Biotechnology Journal
- A trans-amplifying RNA vaccine strategy for induction of potent protective immunity
- (2019) Tim Beissert et al. MOLECULAR THERAPY
- Advances in RNA Vaccines for Preventive Indications: A Case Study of A Vaccine Against Rabies
- (2019) Armbruster et al. Vaccines
- Establishing Preferred Product Characterization for the Evaluation of RNA Vaccine Antigens
- (2019) Cristina Poveda et al. Vaccines
- Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response
- (2019) Sergio Linares-Fernández et al. TRENDS IN MOLECULAR MEDICINE
- A guide to large-scale RNA sample preparation
- (2018) Lorenzo Baronti et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine
- (2018) Hyokyoung Kwon et al. BIOMATERIALS
- Development of Anti-Human Mesothelin-Targeted Chimeric Antigen Receptor Messenger RNA–Transfected Peripheral Blood Lymphocytes for Ovarian Cancer Therapy
- (2018) Chien-Fu Hung et al. HUMAN GENE THERAPY
- Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses
- (2018) Annette B. Vogel et al. MOLECULAR THERAPY
- mRNA vaccines — a new era in vaccinology
- (2018) Norbert Pardi et al. NATURE REVIEWS DRUG DISCOVERY
- The broad socioeconomic benefits of vaccination
- (2018) David E. Bloom et al. Science Translational Medicine
- mRNA polyplexes with post-conjugated GALA peptides efficiently target, transfect and activate antigen presenting cells
- (2018) Bo Lou et al. BIOCONJUGATE CHEMISTRY
- mRNA transfection by a Xentry-protamine cell-penetrating peptide is enhanced by TLR antagonist E6446
- (2018) Glenn D. Bell et al. PLoS One
- The Current Scientific and Regulatory Landscape in Advancing Integrated Continuous Biopharmaceutical Manufacturing
- (2018) Adam C. Fisher et al. TRENDS IN BIOTECHNOLOGY
- New Vaccine Technologies to Combat Outbreak Situations
- (2018) Susanne Rauch et al. Frontiers in Immunology
- Phase I clinical trial of an intranodally administered mRNA based therapeutic vaccine against HIV-1 infection
- (2018) Lorna Leal et al. AIDS
- Multimodal Chromatography for Purification of Biotherapeutics – A Review
- (2018) Vivek Halan et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Antimicrobial resistance and the role of vaccines
- (2018) David E. Bloom et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing
- (2018) Naidi Sun et al. Scientific Reports
- Poly(lactic acid) nanoparticles and cell-penetrating peptide potentiate mRNA-based vaccine expression in dendritic cells triggering their activation
- (2018) Anne-Line Coolen et al. BIOMATERIALS
- Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial
- (2017) Martin Alberer et al. LANCET
- Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses
- (2017) Kapil Bahl et al. MOLECULAR THERAPY
- Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
- (2017) Norbert Pardi et al. NATURE
- Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide
- (2017) Vimal K. Udhayakumar et al. Advanced Healthcare Materials
- Conscious coupling: The challenges and opportunities of cascading enzymatic microreactors
- (2017) Pia Gruber et al. Biotechnology Journal
- Formation and purification of tailored liposomes for drug delivery using a module-based micro continuous-flow system
- (2017) Nikolay Dimov et al. Scientific Reports
- Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef
- (2016) Rajesh T. Gandhi et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways
- (2016) Man Li et al. JOURNAL OF CONTROLLED RELEASE
- Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
- (2016) Lena M. Kranz et al. NATURE
- mRNA capping: biological functions and applications
- (2016) Anand Ramanathan et al. NUCLEIC ACIDS RESEARCH
- A general method for rapid and cost-efficient large-scale production of 5′ capped RNA
- (2016) Anna-Lisa Fuchs et al. RNA
- From the RNA world to the clinic
- (2016) B. A. Sullenger et al. SCIENCE
- Concise Review: Application of In Vitro Transcribed Messenger RNA for Cellular Engineering and Reprogramming: Progress and Challenges
- (2016) Heidrun Steinle et al. STEM CELLS
- Immune response and long-term clinical outcome in advanced melanoma patients vaccinated with tumor-mRNA-transfected dendritic cells
- (2016) Jon Amund Kyte et al. OncoImmunology
- Induction of HIV-1 gag specific immune responses by cationic micelles mediated delivery of gag mRNA
- (2015) Mengnan Zhao et al. DRUG DELIVERY
- The messenger's great message for vaccination
- (2015) Steve Pascolo Expert Review of Vaccines
- The business impact of an integrated continuous biomanufacturing platform for recombinant protein production
- (2015) Jason Walther et al. JOURNAL OF BIOTECHNOLOGY
- Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases
- (2015) Akitsugu Matsui et al. Scientific Reports
- Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study
- (2015) Hubert Kübler et al. Journal for ImmunoTherapy of Cancer
- mRNA-based therapeutics — developing a new class of drugs
- (2014) Ugur Sahin et al. NATURE REVIEWS DRUG DISCOVERY
- History of vaccination
- (2014) S. Plotkin PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNA: The new revolution in nucleic acid vaccines
- (2013) Andrew J. Geall et al. SEMINARS IN IMMUNOLOGY
- Challenges and advances towards the rational design of mRNA vaccines
- (2013) Charlotte Pollard et al. TRENDS IN MOLECULAR MEDICINE
- A novel, disruptive vaccination technology
- (2013) Karl-Josef Kallen et al. Human Vaccines & Immunotherapeutics
- Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
- (2013) G. L. Beatty et al. Cancer Immunology Research
- The current challenges for vaccine development
- (2012) P. Oyston et al. JOURNAL OF MEDICAL MICROBIOLOGY
- Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection
- (2012) Benjamin Petsch et al. NATURE BIOTECHNOLOGY
- Developing mRNA-vaccine technologies
- (2012) Thomas Schlake et al. RNA Biology
- A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption
- (2011) Sabine D. Allard et al. CLINICAL IMMUNOLOGY
- Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation
- (2011) M Diken et al. GENE THERAPY
- The development of vaccines: how the past led to the future
- (2011) Stanley A. Plotkin et al. NATURE REVIEWS MICROBIOLOGY
- Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
- (2011) Katalin Karikó et al. NUCLEIC ACIDS RESEARCH
- Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity
- (2010) S. Kreiter et al. CANCER RESEARCH
- Rapid, nondenaturing RNA purification using weak anion-exchange fast performance liquid chromatography
- (2010) L. E. Easton et al. RNA
- Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients
- (2009) Benjamin Weide et al. JOURNAL OF IMMUNOTHERAPY
- Vaccination greatly reduces disease, disability, death and inequity worldwide
- (2008) FE Andre et al. BULLETIN OF THE WORLD HEALTH ORGANIZATION
- Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA
- (2008) Benjamin Weide et al. JOURNAL OF IMMUNOTHERAPY
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