Can the Shape of Nanoparticles Enable the Targeting to Cancer Cells over Healthy Cells?

Nanomedicine Reformulation of Chloroquine and Hydroxychloroquine

(2021) David M. Stevens et al.   MOLECULES

Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics

(2021) Joshua J. Rennick et al.   Nature Nanotechnology

Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

(2021) Hua Su et al.   CANCER CELL

Macropinocytosis confers resistance to therapies targeting cancer anabolism

(2020) Vaishali Jayashankar et al.   Nature Communications

Tailored Lipoprotein‐Like miRNA Delivery Nanostructure Suppresses Glioma Stemness and Drug Resistance through Receptor‐Stimulated Macropinocytosis

(2020) Gan Jiang et al.   Advanced Science

Targeted crystallization of mixed-charge nanoparticles in lysosomes induces selective death of cancer cells

(2020) Magdalena Borkowska et al.   Nature Nanotechnology

Insights from nanomedicine into chloroquine efficacy against COVID-19

(2020) Tony Y. Hu et al.   Nature Nanotechnology

Repurposing of well-known medications as antivirals: hydroxychloroquine and chloroquine – from HIV-1 infection to COVID-19

(2020) Sara Naghipour et al.   Expert Review of Anti-Infective Therapy

Hydroxychloroquine-loaded hollow mesoporous silica nanoparticles for enhanced autophagy inhibition and radiation therapy

(2020) Yan Li et al.   JOURNAL OF CONTROLLED RELEASE

The role of caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems

(2020) Canyu Yang et al.   Acta Pharmaceutica Sinica B

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

(2019) Wantong Yao et al.   NATURE

Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

(2019) Nathan D. Donahue et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer-associated fibroblasts promote cisplatin resistance in bladder cancer cells by increasing IGF-1/ERβ/Bcl-2 signalling

(2019) Xingbo Long et al.   Cell Death & Disease

Unexpected Size Effect: The Interplay between Different‐Sized Nanoparticles in Their Cellular Uptake

(2019) Ling Li et al.   Small

Survey of Clinical Translation of Cancer Nanomedicines—Lessons Learned from Successes and Failures

(2019) Hongliang He et al.   ACCOUNTS OF CHEMICAL RESEARCH

Polystyrene Nanoparticles Reduced ROS and Inhibited Ferroptosis by Triggering Lysosome Stress and TFEB Nucleus Translocation in a Size-Dependent Manner

(2019) Lin Li et al.   NANO LETTERS

Quantitative self-assembly prediction yields targeted nanomedicines

(2018) Yosi Shamay et al.   NATURE MATERIALS

Chloroquine and nanoparticle drug delivery: A promising combination

(2018) Joe Pelt et al.   PHARMACOLOGY & THERAPEUTICS

The nutrient environment affects therapy

(2018) Alexander Muir et al.   SCIENCE

Cancer cell nucleus-targeting nanocomposites for advanced tumor therapeutics

(2018) Limin Pan et al.   CHEMICAL SOCIETY REVIEWS

Rod-shaped mesoporous silica nanoparticles for nanomedicine: recent progress and perspectives

(2018) Vu Thanh Cong et al.   Expert Opinion on Drug Delivery

New path to treating pancreatic cancer: TRAIL gene delivery targeting the fibroblast-enriched tumor microenvironment

(2018) Haiping Jiang et al.   JOURNAL OF CONTROLLED RELEASE

Minimum information reporting in bio–nano experimental literature

(2018) Matthew Faria et al.   Nature Nanotechnology

How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

(2018) John P. A. Ioannidis et al.   Nature Biomedical Engineering

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer

(2017) E Hessmann et al.   GUT

Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes

(2017) Peter Popp Wibroe et al.   Nature Nanotechnology

Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

(2017) Jia-Lin Huang et al.   Nature Communications

Ependymomas overexpress chemoresistance and DNA repair-related proteins

(2017) Sherise D. Ferguson et al.   Oncotarget

Mesoporous silica nanorods for improved oral drug absorption

(2017) Nan Zheng et al.   Artificial Cells Nanomedicine and Biotechnology

A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery

(2017) Joy Wolfram et al.   Scientific Reports

Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin

(2016) Yang Wang et al.   Autophagy

Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity

(2016) F. Perche et al.   BIOMATERIALS

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

(2016) Min Pan et al.   NATURE CELL BIOLOGY

Pair correlation microscopy reveals the role of nanoparticle shape in intracellular transport and site of drug release

(2016) Elizabeth Hinde et al.   Nature Nanotechnology

MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity

(2016) George Sharbeen et al.   Oncotarget

Delineating the Role of βIV-Tubulins in Pancreatic Cancer: βIVb-Tubulin Inhibition Sensitizes Pancreatic Cancer Cells to Vinca Alkaloids

(2016) G. Sharbeen et al.   NEOPLASIA

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Dual Bioresponsive Mesoporous Silica Nanocarrier as an “AND” Logic Gate for Targeted Drug Delivery Cancer Cells

(2014) Xin Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Shape and Orientation Matter for the Cellular Uptake of Nonspherical Particles

(2014) Sabyasachi Dasgupta et al.   NANO LETTERS

Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis

(2014) M. Maekawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KRAS: feeding pancreatic cancer proliferation

(2014) Kirsten L. Bryant et al.   TRENDS IN BIOCHEMICAL SCIENCES

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Effect of homotypic and heterotypic interaction in 3D on the E-selectin mediated adhesive properties of breast cancer cell lines

(2012) Siddarth Chandrasekaran et al.   BIOMATERIALS

Impact of Tumor Microenvironment and Epithelial Phenotypes on Metabolism in Breast Cancer

(2012) H. A. Brauer et al.   CLINICAL CANCER RESEARCH

Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated Monodisperse Mesoporous Silica Nanoparticles

(2012) Limin Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

(2012) C. Lee et al.   Science Translational Medicine

Aspect Ratio Determines the Quantity of Mesoporous Silica Nanoparticle Uptake by a Small GTPase-Dependent Macropinocytosis Mechanism

(2011) Huan Meng et al.   ACS Nano

Receptor-Mediated Endocytosis of Nanoparticles of Various Shapes

(2011) Robert Vácha et al.   NANO LETTERS

Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index

(2010) C. Lee et al.   CANCER RESEARCH

Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy

(2010) Liming Wang et al.   NANO LETTERS

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function

(2009) Xinglu Huang et al.   BIOMATERIALS

HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes

(2009) Kosuke Miyauchi et al.   CELL

Caveolae Mediate Growth Factor-induced Disassembly of Adherens Junctions to Support Tumor Cell Dissociation

(2009) Lidiya Orlichenko et al.   MOLECULAR BIOLOGY OF THE CELL

Size Effect on Cell Uptake in Well-Suspended, Uniform Mesoporous Silica Nanoparticles

(2009) Fang Lu et al.   Small

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

(2008) A. Vonlaufen et al.   CANCER RESEARCH