Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

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Biological Functions of Autophagy Genes: A Disease Perspective

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Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

(2019) Conan G. Kinsey et al.   NATURE MEDICINE

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(2019) Kirsten L. Bryant et al.   NATURE MEDICINE

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

(2019) Wantong Yao et al.   NATURE

Autophagic cell death restricts chromosomal instability during replicative crisis

(2019) Joe Nassour et al.   NATURE

NRF2 Activation in Cancer: From DNA to Protein

(2019) Erica W. Cloer et al.   CANCER RESEARCH

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(2019) Apirat Chaikuad et al.   BIOCHEMICAL JOURNAL

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(2019) Thomas B. Karasic et al.   JAMA Oncology

Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition

(2019) Christina G. Towers et al.   DEVELOPMENTAL CELL

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(2019) Ravi K. Amaravadi et al.   Cancer Discovery

Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis

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Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins

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Activation of p62/SQSTM1–Keap1–Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer

(2018) Yoshinobu Ichimura et al.   Frontiers in Oncology

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(2018) Wilhelm Palm   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

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Macropinocytosis and autophagy crosstalk in nutrient scavenging

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VPS34 Acetylation Controls Its Lipid Kinase Activity and the Initiation of Canonical and Non-canonical Autophagy

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Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy

(2017) Heeseon An et al.   NATURE CELL BIOLOGY

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

(2017) Orianne Olivares et al.   Nature Communications

Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer

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Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model

(2016) Ana Mesquita et al.   Autophagy

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

(2016) Atsushi Umemura et al.   CANCER CELL

p62 in Cancer: Signaling Adaptor Beyond Autophagy

(2016) Jorge Moscat et al.   CELL

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(2016) Haoqiang Ying et al.   GENES & DEVELOPMENT

Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion

(2016) Lee Dolat et al.   JOURNAL OF CELL BIOLOGY

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Global Analysis of Cellular Protein Flux Quantifies the Selectivity of Basal Autophagy

(2016) Tian Zhang et al.   Cell Reports

Improvement of gemcitabine sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells by RUNX2 depletion-mediated augmentation of TAp73-dependent cell death

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p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy inDrosophilaAre Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB

(2015) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

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Determining the macropinocytic index of cells through a quantitative image-based assay

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Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas

(2013) Zuoxiang Xiao et al.   CANCER CELL

Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice

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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

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p62 Links β-adrenergic input to mitochondrial function and thermogenesis

(2012) Timo D. Müller et al.   JOURNAL OF CLINICAL INVESTIGATION

COG6 Interacts with a Subset of the Golgi SNAREs and Is Important for the Golgi Complex Integrity

(2012) Tetyana Kudlyk et al.   TRAFFIC

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Macropinocytosis: an endocytic pathway for internalising large gulps

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

KeaA, a Dictyostelium kelch-domain protein that regulates the response to stress and development

(2010) Luciana Mantzouranis et al.   BMC DEVELOPMENTAL BIOLOGY

Glutamine Deprivation Induces Abortive S-Phase Rescued by Deoxyribonucleotides in K-Ras Transformed Fibroblasts

(2009) Daniela Gaglio et al.   PLoS One

IKKα Is Required to Maintain Skin Homeostasis and Prevent Skin Cancer

(2008) Bigang Liu et al.   CANCER CELL